Based on a longitudinal case study of four interorganizational product development collaborations, this paper identifies a lure to cross-functional integration that has hereto been neglected. In particular, findings suggest that when the buyer firm separates the Research and Development (R&D) Department from the Procurement Department, the two departments play a good cop-bad cop strategy towar

This paper addresses the challenge of striking a balance between, on one hand, mitigating uncertainty through the existence of systematic processes and structures and, on the other, stimulating creativity through allowable variation in work processes and structures. Both objectives are fundamental aspects of product development work. Our main finding is that both objectives can be achieved simulta

Hardwood spent sulphite liquors (HSSLs) are by-products from the pulping industry rich in pentoses, which are not yet fully exploited for bioprocessing, namely for the production of bioethanol. The sustainable fermentation of pentoses into bioethanol is a challenge to overcome. Besides sugars, HSSLs contains inhibitors that decrease the possibility of bioprocessing of these by-products. Neverthele

Dame Margaret Drabble’s The Millstone can profitably be read as shedding light on personal identity and moral development as well as how these connect to contemporary society, history, friendship, self-knowledge and self-deception in a way that ought to be of interest to classic perfectionist theories, i.e. ethical theories that develop an account of ethics informed by an account of the good human

What does recognition mean for people whose sexuality has for a long time been criminalised? Over the last years, the recognition of India’s queers has been the focus of numerous contestations as a result of the complex developments around Section 377 of the Indian Penal Code, which criminalises ‘carnal acts against the order of nature’. The Section had been partially repealed in 2009 by the Delhi

The purpose of this work is the investigation of some constitutive and configurational aspects of phenomenological model formulations for a class of materials with history-dependent gradient microstructure. The assumption that the behavior of a material point is affected by history-dependent processes in a finite neighbor of this point yields an extended continuum characterized by non-simple mater

With a high share of motor vehicles yielding to crossing cyclists, cyclists’ waiting time decreases and their level of service increases. The main aim of this paper is to study how this propensity to yield is connected to the traffic safety situation for cyclists at cycle crossings in a Swedish context. In a previous study, motor vehicle drivers’ yielding behaviour was studied at 65 cycle crossing

Proteomic experiments can be difficult to handle because of the large amount of data in different formats that is generated. Samples need to be managed and generated, data needs to be integrated with samples and annotation information. A laboratory information management system (LIMS) can be used to overcome some of the data handling problems. In this chapter, we discuss the role of a LIMS in the

We constructed a single-chain Fv antibody library that permits human complementarity-determining region (CDR) gene fragments of any germline to be incorporated combinatorially into the appropriate positions of the variable-region frameworks VH-DP47 and VL-DPL3. A library of 2 x 109 independent transformants was screened against haptens, peptides, carbohydrates, and proteins, and the selected antib

Glycoprotein B (gB, gpUL55) is the major antigen for the induction of neutralizing antibodies against human cytomegalovirus (HCMV), making it an attractive molecule for active and passive immunoprophylaxis. The region between aa 552 and 635 of HCMV gB (termed AD-1) has been identified as the immunodominant target for the humoral immune response following natural infection. AD-1 represents a comple

A novel technology in the area of antibody engineering has been developed which allows for the creation of new types of antibody molecules. It is called complementarity-determining region (CDR) implantation and permits the random combination of CDR sequences formed in vivo into a single master framework. Thus, totally new gene combinations can be produced and used in selection processes. The resul

Experiments were carried out to analyze the function of cysteine residues at amino acid positions 506 (cI), 550 (cII), 573 (cIII), and 610 (cIV), in dimerization and/or disulfide linkage of human cytomegalovirus (HCMV) glycoprotein B (gB). Single c-codons or pairs were substituted in the gB sequence of constructs which were used for transfection and selection of stable transfectants. Analysis of g

Working with phage display, there are a number of ways for characterizing the phage and the molecules that they display. BIAcore(TM) biosensor and Origen Analyzer provide novel detection systems permitting sensitive and flexible analyses. Such analytical approaches are of critical importance to allow early selection of appropriate clones for further evaluation. In this review we describe the appli

IgM antibodies are often of low affinity (dissociation constant (K(d)) > 10-5 M) and therefore they are usually neglected as tools in, e.g., immunoassays. Previous studies have shown that low affinity biological interactions can be studied and exploited in affinity chromatography, biosensor technology and capillary electrophoresis. In this study we have demonstrated that IgM can be a useful ligand