Exploring small heat shock protein chaperones by crosslinking mass spectrometry
Popular Abstract in Swedish Byggstenarna av allt liv på denna planet är celler. Vår egen kropp till exempel består av ungefär 10 biljon (1013) celler. De flesta bakterier består av bara en cell. Inne i cellerna finns alla de biomolekyler som styr livet, såsom proteiner, sockerarter, lipider, och DNA. Celler är otroligt fullpackade, särskilt vad gäller proteiner, med protein koncentrationer av up tTogether with other molecular chaperones, small heat shock proteins are key components of the protein quality control system, which is comprised of several hundred proteins and acts to maintain proteome homeostasis in the cell. Small heat shock proteins bind unfolding proteins at an early stage, to prevent these from further unfolding and aggregating. Partially unfolded proteins are being held in
