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Thyroid Hormones in the Brain and Their Impact in Recovery Mechanisms After Stroke

Thyroid hormones are of fundamental importance for brain development and essential factors to warrant brain functions throughout life. Their actions are mediated by binding to specific intracellular and membranous receptors regulating genomic and non-genomic mechanisms in neurons and populations of glial cells, respectively. Among others, mechanisms include the regulation of neuronal plasticity pr

Non-invasive imaging methodologies for assessment of radiation damage to bone marrow and kidneys from peptide receptor radionuclide therapy. : -

Background/Aims: Peptide receptor radionuclide therapy (PRRT) is becoming clinical routine for management of Neuroendocrine Tumours. The number of PRRT cycles are correlated with treatment effect but theoretically limited by off-target radiation damage to kidneys and bone marrow. New imaging biomarkers for assessment of PRRT tissue damage would enable evaluation of novel renal and bone marrow protBackground/Aims: Peptide receptor radionuclide therapy (PRRT) is becoming clinical routine for management of neuroendocrine tumours. The number of PRRT cycles is correlated with treatment effect but theoretically limited by off-target radiation damage to kidneys and bone marrow. New imaging biomarkers for assessment of PRRT tissue damage would enable evaluation of novel renal and bone marrow prote

Mortality risks associated with sibling heart failure

Background The mortality in individuals with a family history of heart failure (HF) has not been determined. This nationwide sib-pair study aimed to determine mortality in individuals with a sibling affected with HF. Methods Sib-pairs were linked using the Swedish Multi-Generation Register, the Hospital Discharge Register and the Cause of Death Register for the period 1987–2012. Families with card

Epigenome- and Transcriptome-wide Changes in Muscle Stem Cells from Low Birth Weight Men

Background: Being born with low birth weight (LBW) is a risk factor for muscle insulin resistance and type 2 diabetes (T2D), which may be mediated by epigenetic mechanisms programmed by the intrauterine environment. Epigenetic mechanisms exert their prime effects in developing cells. We hypothesized that muscle insulin resistance in LBW subjects may be due to early differential epigenomic and tran

Dinosaur paleohistology : Review, trends and new avenues of investigation

In the mid-19th century, the discovery that bone microstructure in fossils could be preserved with fidelity provided a new avenue for understanding the evolution, function, and physiology of long extinct organisms. This resulted in the establishment of paleohistology as a subdiscipline of vertebrate paleontology, which has contributed greatly to our current understanding of dinosaurs as living org

On the Structure of Solid Lipid Nanoparticles

Solid lipid nanoparticles (SLNs) have a crystalline lipid core which is stabilized by interfacial surfactants. SLNs are considered favorable candidates for drug delivery vehicles since their ability to store and release organic molecules can be tailored through the identity of the lipids and surfactants used. When stored, polymorphic transitions in the core of drug-loaded SLNs lead to the prematur

Integrative analysis of prognostic biomarkers derived from multiomics panels helps discrimination of chronic kidney disease trajectories in people with type 2 diabetes

Clinical risk factors explain only a fraction of the variability of estimated glomerular filtration rate (eGFR) decline in people with type 2 diabetes. Cross-omics technologies by virtue of a wide spectrum screening of plasma samples have the potential to identify biomarkers for the refinement of prognosis in addition to clinical variables. Here we utilized proteomics, metabolomics and lipidomics

Protein Dimensions and Interactions at Immune-Cell Contacts

Immune cells, such as B and T cells, fight pathogens infecting the human body. To fulfil this function the immune cells need to form a contact during which different membrane proteins play an important role. A key event in this contact is the interaction between the T-cell receptor (TCR) and an antigenic peptide-presenting major histocompatibility complex (MHC) protein. If this interaction is suff

Compilation and Translation : Johannes Widekindi and the Origins of his Work on a Swedish-Russian War

The purpose of the dissertation is to trace the working process of Johannes Widekindi (ca 1620–1678), Swedish historiographer of the Realm, when writing his bilingual history of the Swedish military actions in Russia in 1609–1617, published in 1671 in Swedish as Thet Swenska i Ryssland tijo åhrs Krijgz-Historie and in 1672 in Latin as Historia Belli Sveco-Moscovitici Decennalis.Chapter 1 of the di

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Rapporten er utarbeidet i forbindelse med FoU-prosjektet «Virkningene av voldsoffererstatning». Prosjektet har hatt som formål å gi økt kunnskap om virkninger, i betydning av bruker- og samfunnseffektene av voldsoffererstatningen.Oppdraget er gjennomført av Oxford Research. Prosjektleder har vært sjefanalytiker Tor Egil Viblemo ved Oxford Research og prosjektdeltakerne har vært Vegard Solhjem Knut

Om "kodifierad statsrätt"

Detta kapitel kommer främst att förhålla sig till koncepten ”kodifierad statsrätt” och rätten som ”formell ordning”. Den rättssociologiska forskningens rättsliga betydelse behandlas också, och hur rättssociologisk forskning kan vara betydelsefull för att lösa juridiska problem och kanske även utgöra en ”rättskälla”. Kapitlet syftar därför till att ge ett exempel på hur man kan se på ”rättssociolog

Avtalet som rättsligt och socialt instrument

Detta kapitel behandlar ett rättsligt instrument, avtalet, utifrån ett empiriskt perspektiv. Syftet är tvåfaldigt; dels att lyfta fram en inom rättssociologin försummad regleringsform, dels att ge en bild av vilka forskningsuppgifter studiet av avtal kan föra med sig. Det finns väsentliga skillnader mellan avtal och lag som rättsliga instrument. Lag som bekant är föreskrivande och talar om vad som

A rigid spirocyclic diol from fructose-based 5-hydroxymethylfurfural: synthesis, life-cycle assessment, and polymerization for renewable polyesters and poly(urethane-urea)s

There is currently an intensive development of sugar-based building blocks toward the production of renewable high performance plastics. In this context, we report on the synthesis of a rigid diol with a spirocyclic structure via a one-step acid-catalyzed acetalation of fructose-sourced 5-hydroxymethylfurfural and pentaerythritol. Preliminary life cycle assessment (LCA) indicated that the spiro-di

The vertical influence of temperature and precipitation on snow cover variability in the Central Tianshan Mountains, Northwest China

Seasonal snow cover in mountainous regions will affect local climate and hydrology. In this study, we assessed the role of altitude in determining the relative importance of temperature and precipitation in snow cover variability in the Central Tianshan Mountains. The results show that: (a) in the study area, temperature has a greater influence on snow cover than precipitation during most of the t

Understanding the complexity of socioeconomic disparities in type 2 diabetes risk: A study of 4.3 million people in Sweden

Objective Investigating demographic and socioeconomic factors as intersecting rather than as separate dimensions may improve our understanding of the heterogeneous distribution of type 2 diabetes in the population. However, this complexity has scarcely been investigated and we still do not know the accuracy of these factors for predicting type 2 diabetes. Improved understanding of the demographic

Aggregation of value judgments differs from aggregation of preferences

My focus is on aggregation of individual value rankings of alternatives to a collective value ranking. This is compared with aggregation o individual prefrences to a collective preference. While in an individual preference ranking the alternatives are ordered in accordance with one’s preferences, the order in a value ranking expresses one’s comparative evaluation of the alternatives, from the best

Effect of Liraglutide on Times in Glycaemic Ranges as Assessed by CGM for Type 2 Diabetes Patients Treated With Multiple Daily Insulin Injections

Introduction: The effects of the GLP-1 analogue liraglutide on time in hypoglycaemia, time in hyperglycaemia, and time in range for type 2 diabetes patients initially treated with multiple daily insulin injections (MDI) were investigated. Variables associated with hypoglycaemia in the current population were also identified. Methods: Analyses were based on data from a previously performed double-b