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Health-Related Quality of Life of Patients Receiving Low-toxicity Immunosuppressive Regimens:. A Substudy of the Symphony Study

Objective. To evaluate health-related quality of life (HRQoL) in patients with different low-toxicity regimens post-transplantation. Methods. One hundred fifty-six patients were randomized to standard-dose cyclosporine A (CsA), mycophenolate mofetil, and corticosteroids or daclizumab induction, mycophenolate mofetil, and corticosteroids with a low dose of CsA, tacrolimus (Low-Tac), or sirolimus. S

Belonia nidarosiensis funnen i Sverige

Redan för några år sedan hittade Mikael Hagström och Jan Henriksson B. nidarosiensis på Gotland, men av flera anledningar har det tagit lite tid att få klarhet vad det var för art. Nedan beskriver de tillsammans med Ulf Arup hela historien om fynden på Gotland.

Complement in the brain

The brain is considered to be an immune privileged site, because the blood-brain barrier limits entry of blood borne cells and proteins into the central nervous system (CNS). As a result, the detection and clearance of invading microorganisms and senescent cells as well as surplus neurotransmitters, aged and glycated proteins, in order to maintain a healthy environment for neuronal and glial cells

Effect of Probiotic Bacteria on Microbial Host Defense, Growth, and Immune Function in Human Immunodeficiency Virus Type-1 Infection

The hypothesis that probiotic administration protects the gut surface and could delay progression of Human Immunodeficiency Virus type1 (HIV-1) infection to the Acquired Immunodeficiency Syndrome (AIDS) was proposed in 1995. Over the last five years, new studies have clarified the significance of HIV-1 infection of the gut associated lymphoid tissue (GALT) for subsequent alterations in the microfl

In Vivo Reprogramming for Brain and Spinal Cord Repair(1,2,3).

Cell reprogramming technologies have enabled the generation of various specific cell types including neurons from readily accessible patient cells, such as skin fibroblasts, providing an intriguing novel cell source for autologous cell transplantation. However, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integrat

Indirekt förändrad markanvändning och biodrivmedel - en kunskapsöversikt

Under senare år har det pågått en debatt om biodrivmedels klimatnytta, detta sedan studier visat att indirekt förändrad markanvändning kan leda till stora utsläpp av växthusgaser. Ökad produktion av biodrivmedel i ett land kan leda till att annan produktion trängs undan, vilket i förlängningen kan leda till omvandling av skogs- eller betesmark till jordbruksmark i andra länder; detta benämns ofta

An antimicrobial helix A-derived peptide of heparin cofactor II blocks endotoxin responses in vivo.

Host defense peptides are key components of the innate immune system, providing multi-facetted responses to invading pathogens. Here, we describe that the peptide GKS26 (GKSRIQRLNILNAKFAFNLYRVLKDQ), corresponding to the A domain of heparin cofactor II (HCII), ameliorates experimental septic shock. The peptide displays antimicrobial effects through direct membrane disruption, also at physiological

New tool for promotion of energy management and cleaner production on no cure, no pay basis

Even enterprises with very advanced management systems seldom monitor efficiency of energy usage and materials flows within their processes and have, therefore, difficulty to effectively manage their resource efficiency. This paper is built upon experiences from a pilot implementation of a new tool for promotion of energy management and cleaner production, developed within the Energy Management an

The Malady of Emigrants: Homesickness and Longing in the Colony of New Sweden (1638-1655)

This chapter explores homesickness of the Swedish colonial employees in the settlement of New Sweden and pays attention to the potential role of material culture in instigating feelings of longing. In the seventeenth century, in the age of wars fought far from home, colonial expansion and transoceanic resettlements, homesickness became a considerable social problem. In 1688, Johannes Hofer, a Swis

Prediction of stopping-power ratios in flattening-filter free beams.

PURPOSE: In recent years, there has been an increasing interest in flattening-filter free (FFF) beams. However, since the removal of the flattening filter will affect both the mean and the variance of the energy spectrum, current beam-quality specifiers may not be adequate for reference dosimetry in such beams. The purpose of this work was to investigate an alternative, more general beam-quality s

Selective and simultaneous determination of trace bisphenol A and tebuconazole in vegetable and juice samples by membrane-based molecularly imprinted solid-phase extraction and HPLC

Nanofibrous molecularly imprinted membranes (nano-MIMs) with multi-analyte selectivity were prepared by encapsulating two types of molecularly imprinted polymer nanoparticles (MIP-NPs) into electrospun polyvinyl alcohol nanofibers. The obtained nano-MIMs maintained high molecular selectivity offered by each of the MIP-NPs. Nano-MIM embedding BPA-imprinted nanoparticles and TBZ-imprinted nanopartic

Real-world cost-effectiveness in chronic myeloid leukemia: the price of success during four decades of development from non-targeted treatment to imatinib

Imatinib has revolutionized the treatment of chronic myeloid leukemia (CML). We evaluated clinical outcome and cost-effectiveness, using Swedish registry data based on patients with CML diagnosed 1973-2008. Outcome from three time periods (I: 1973-1979; II: 1991-1997; III: 2002-2008) associated with symptomatic treatment, interferon-alpha/stem cell transplant and implementation of imatinib, respec

Photochemistry of carbon monoxide and methanol in water and nitric acid hydrate ices: A NEXAFS study

Soft X-ray induced chemistry of H2O, CO and CH3OH and the effects of the water and nitric acid hydrate (HNO3 center dot 1.65H(2)O) matrix on the photochemistry of CO and CH3OH have been investigated using NEXAFS spectroscopy. For pure H2O, CO and CH3OH ices, we show that the destruction rates are strongly limited by back reactions, leading to strikingly high survival rates of these molecules upon

Microscopic colitis and reproductive factors related to exposure to estrogens and progesterone.

Microscopic colitis (MC) often debuts around or after menopause and is divided into lymphocytic- and collagenous colitis. The aim of this study was to examine whether factors influencing sex hormone levels differed between subgroups of MC as well as between patients and controls. A self-administered questionnaire about parity was completed which included questions surrounding age at first childbir

Cancer predisposing BARD1 mutations in breast-ovarian cancer families

The breast cancer susceptibility gene BARD1 (BRCA1-associated RING domain protein, MIM# 601593) acts with BRCA1 in DNA double-strand break (DSB) repair and also in apoptosis initiation. We screened 109 BRCA1/2 negative high-risk breast and/or ovarian cancer patients from North-Eastern Poland for BARD1 germline mutations using a combination of denaturing high-performance liquid chromatography and d