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High salt intake increases copeptin but salt sensitivity is associated with fluid induced reduction of copeptin in women.

This study investigated if copeptin is affected by high salt intake and whether any salt-induced changes in copeptin are related to the degree of salt sensitivity. The study was performed on 20 men and 19 women. In addition to meals containing 50 mmol NaCl daily, capsules containing 100 mmol NaCl and corresponding placebo capsules were administered during 4 weeks each, in random order. Measurement

Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases.

The risk of distant recurrence in breast cancer patients is difficult to assess with current clinical and histopathological parameters, and no validated serum biomarkers currently exist. Using a recently developed recombinant antibody microarray platform containing 135 antibodies against 65 mainly immunoregulatory proteins, we screened 240 sera from 64 patients with primary breast cancer. This uni

Do Genetic Factors Modify the Relationship Between Obesity and Hypertriglyceridemia? : Findings From the GLACIER and the MDC Studies

BACKGROUND: Obesity is a major risk factor for dyslipidemia, but this relationship is highly variable. Recently published data from 2 Danish cohorts suggest that genetic factors may underlie some of this variability.METHODS AND RESULTS: We tested whether established triglyceride-associated loci modify the relationship of body mass index (BMI) and triglyceride concentrations in 2 Swedish cohorts (t

Ion Mobility Analysis of Lipoprotein Subfractions Identifies Three Independent Axes of Cardiovascular Risk.

OBJECTIVE: Whereas epidemiological studies show that levels of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) predict incident cardiovascular disease (CVD), there is limited evidence relating lipoprotein subfractions and composite measures of subfractions to risk for CVD in prospective cohort studies. METHODS AND RESULTS: We tested whether combinations

Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals.

Two major high-penetrance breast cancer genes, BRCA1 and BRCA2, are responsible for approximately 20% of hereditary breast cancer (HBC) cases in Finland. Additionally, rare mutations in several other genes that interact with BRCA1 and BRCA2 increase the risk of HBC. Still, a majority of HBC cases remain unexplained which is challenging for genetic counseling. We aimed to analyze additional mutatio

Kittinger and Baumgartner: on a mission to the edge of space

On 15 March 2012, Felix Baumgartner jumped from 71 500 feet [1], a test jump as part of his attempt to beat the earlier record set by Joe Kittinger, who jumped from 102 800 feet in 1960, as part of the US space programme [2] The ascent to these elevations in a helium balloon, followed by free fall, with varying temperatures and speed of sound, and increasing air resistance and density, can lead te

Diffusion and perfusion MRI of the brain in comatose patients treated with mild hypothermia after cardiac arrest: A prospective observational study.

BACKGROUND: Outcome for resuscitated cardiac arrest (CA) patients is poor. The 1-year survival rate with favourable neurological outcome (CPC 1-2) after out-of-hospital CA is reported to be 4%. Among resuscitated patients treated within an ICU, approximately 50% regain consciousness, whereas the other 50% remain comatose before they die. Induced hypothermia significantly improves the neurological

Abnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome.

Abnormal auditory information processing has been reported in individuals with autism spectrum disorders (ASD). In the present study auditory processing was investigated by recording auditory brainstem responses (ABRs) elicited by forward masking in adults diagnosed with Asperger syndrome (AS). Sixteen AS subjects were included in the forward masking experiment and compared to three control groups

Familial risks in cancer of unknown primary: tracking the primary sites.

PURPOSE Cancer of unknown primary (CUP) is diagnosed at the metastatic stage, and despite extensive diagnostic work-up, the primary tumor often remains unidentified. No data are available on familial clustering of CUP. We hypothesize that familial clustering of CUP with other cancers may be informative of the primary sites. PATIENTS AND METHODS A total of 35,168 patients with CUP were identified i

Ska inte vara möjligt att ta patent på gener

USA:s högsta domstol har nyligen beslutat att bioteknikföretaget Myriad Genetics inte får ta patent på de två viktigaste bröstcancergenerna. Detta beslut bör leda till en ändring av den svenska genlagstiftningen. Det skriver professor Bengt Olle Bengtsson.

Broad band synthetic seismograms for a spherical inhomogeneity in a many-layered elastic half-space

The propagation of elastic waves in a many-layered elastic half-space is considered. One of the layers contains a bounded inhomogeneity which in the numerical applications is taken as a sphere. The half-space is excited by an explosion, modelled as a sudden isotropic point source. First the time-harmonic problem is solved using the null field approach (the T-matrix method). Starting from surface

Phase-locked high-order harmonic sources

We demonstrate that two harmonic sources generated independently in a xenon gas jet using the same picosecond Nd:YAG laser are locked in phase. The experiment is performed by separating a laser beam into two parallel beams focused at different locations under the nozzle of a gas jet, and therefore producing two independent sources of harmonic radiation, and studying the pattern obtained in the far

Experiences of living with advanced colorectal cancer from two perspectives - Inside and outside.

PURPOSE: To investigate how life situation by persons with advanced colorectal cancer and their partners is affected by living with the disease and its treatment. METHOD: Separate, individual interviews were made with persons with advanced colorectal cancer (n = 12) and their partners (n = 9) about how their daily lives were affected by the disease and its treatment. The verbatim transcripts were