This article discusses the role of the protein corona in delivery systems with tagged nanoparticles and how knowledge of the protein corona can help in optimizing delivery. The basic question is whether and how the binding of proteins and other biomolecules at the nanoparticle surface interfere with the interaction between a tag and its receptor. This is an interesting problem in many respects, bu

We report on the first measurement of an excess in the yield of J/ψ at very low transverse momentum (pT

The objective of this study was to describe the natural history of HIV-1 RNA load in vertically HIV-1-infected children. HIV-1 RNA in 156 plasma or serum samples (1-14, median 4 from each child) from 32 vertically HIV-1-infected children was detected with the NASBA® technique (Organon Teknika, The Netherlands). Twenty-one children were prospectively followed from birth, and 11 were identified and

Purpose: We present clinical and laboratory data on 18 children from 12 hemophilia treatment centers in the United States, Canada, and Europe with the purpose of disseminating information regarding a recently recognized, potentially life-threatening complication of treatment in very young children with hemophilia B. Patients and Methods: Twelve hemophilia centers from the United States, Canada, an

Melt fragments in melt breccias from the Gardnos impact crater, Norway, contain abundant carbon. A high proportion of the carbon present in the original melt was preserved. The stripping of hydrogen from carbon during melting prevents later hydrocarbon formation, hence the carbon is fixed in place rather than volatilized. Underlying lithic breccias that were not melted record hydrocarbon generatio

Research indicates that expert performance is domain specific and hardly transfers to novel tasks or domains. However, due to technological changes in dynamic work settings, experts sometimes need to adapt and transfer their skills to new task affordances. The present mixed method study investigates whether eye movement modeling examples (EMME) can promote adaptive expertise in medical image diagn

OBJECTIVES: To identify germ line variants contributing to the development of monoclonal gammopathy of undetermined significance (MGUS), an asymptomatic premalignant precursor for multiple myeloma (MM).METHODS: We conducted the first genomewide association study (GWAS) on MGUS on 243 German cases with a replication on 294 Czech cases. Identified loci were further analyzed in 1508 German MM patient

The predominant way of modelling mortality rates is the Lee–Carter model and its many extensions. The Lee–Carter model and its many extensions use a latent process to forecast. These models are estimated using a two-step procedure that causes an inconsistent view on the latent variable. This paper considers identifiability issues of these models from a perspective that acknowledges the latent vari

Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk

We have used femtosecond resolution UV-visible and Kβ x-ray emission spectroscopy to characterize the electronic excited state dynamics of [Fe(bpy)2(CN)2], where bpy=2,20-bipyridine, initiated by metal-to-ligand charge transfer (MLCT) excitation. The excited-state absorption in the transient UV-visible spectra, associated with the 2,20-bipyridine radical anion, provides a robust marker for the MLC

BACKGROUND: Crosslinked enzyme aggregates (CLEA) technology is a rapid and versatile method to produce immobilized enzymes via precipitation and cross-linking. A direct relationship between CLEA final activity and process parameters is however yet to be clarified. To address the issue, we have used a factorial design to test the formation and optimization of CLEA made from technical grade cellulas

The research aims to language analysis of the Arab critical speech, which dealt with the study of narrative, in the theoretical and practical side, using pragmatic mechanisms, including holdings of terms, and effective tools in linguistic studies. It’s the starting point for many of the process of modern literary criticism. The study has taken two ways: first, the side of theoretical through summa

A search is presented for new resonances decaying to a W or Z boson and a Higgs boson in the ℓ+ℓ−bb¯, ℓνbb¯, and νν¯bb¯ channels in pp collisions at s=13 TeV with the ATLAS detector at the Large Hadron Collider using a total integrated luminosity of 3.2 fb−1. The search is conducted by looking for a localized excess in the WH/ZH invariant or transverse mass distribution. No significant excess is o

Background: Effects following a hip fracture often lead to functional disabilities and increased dependence on others. Although persons sustaining a hip fracture constitute a heterogeneous group in Swedish health care, they tend to be treated as a homogenous one. Aim: The aim of this study was to reveal how previously healthy people, aged 65 years and older, described how they had adapted to daily

Background: Neuropeptides, such as substance P (SP), have long been seen as mediators of widespread continuous airway inflammation, a process known as neurogenic inflammation. However, this has been difficult to demonstrate clinically, suggesting an alternative role for these signaling molecules. Objectives: We sought to examine the role of SP in nasal infection by assessing the release of SP in r