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Influence of beliefs about health and illness on self-care and care-seeking in foreign-born people with diabetic foot ulcers : Dissimilarities related to origin

Objective: To describe beliefs about health and illness among foreign-born people with diabetic foot ulcers that might affect selfreported self-care and health-care seeking and to study whether there are dissimilarities related to origin. Method: Qualitative descriptive study. Semi-structured interviews with people aged 38-86 years; 13 born in European and 13 in non-European countries (all except

Iridophore- and Xanthophore-Deficient Melanistic Color Variant of the Lizard Plestiodon latiscutatus

Elucidating the ultimate and proximate mechanisms of melanistic color pattern formation has become an important focus of evolutionary biology. There are relatively few studies, however, examining the composition and architecture of pigment cells in melanistic reptiles. The typical color pattern of the skink Plestiodon latiscutatus, which inhabits the Izu Islands and Izu Peninsula of Japan, consist

A Publicly Owned Media Company Co-Producing Audiovisual Content? : The case of Film Väst - Invited Keynote Talk

By the late 1960s, the largest Scandinavian film companies had all closed their sound stages and markedly lowered their annual ambitions with regard to production. This may be seen as a response to several different phenomena. First, television, a medium that was introduced in the region from the mid-1950s on, meant that films lost their habitual audience. Second, the introduction of film support

Crystallization and preliminary structural analysis of the Listeria monocytogenes Ca(2+)-ATPase LMCA1

Ca(2+)-ATPases are ATP-driven membrane pumps that are responsible for the transport of Ca(2+) ions across the membrane. The Listeria monocytogenes Ca(2+)-ATPase LMCA1 has been crystallized in the Ca(2+)-free state stabilized by AlF(4)(-), representing an occluded E2-P(i)-like state. The crystals belonged to space group P2(1)2(1)2 and a complete data set extending to 4.3 Å resolution was collected.

Low Preoperative BMD Is Related to High Migration of Tibia Components in Uncemented TKA-92 Patients in a Combined DEXA and RSA Study With 2-Year Follow-Up

Background: The fixation of uncemented tibia components in total knee arthroplasty may rely on the bone quality of the tibia; however, no previous studies have shown convincing objective proof of this. Component migration is relevant as it has been shown to predict aseptic loosening. Methods: We performed 2-year follow-up of 92 patients who underwent total knee arthroplasty surgery with an uncemen

DIZZYNET - a European network initiative for vertigo and balance research : visions and aims

Vertigo is one of the most common complaints in medicine. Despite its high prevalence, patients with vertigo often receive either inappropriate or inadequate treatment. The most important reasons for this deplorable situation are insufficient interdisciplinary cooperation, nonexistent standards in diagnostics and therapy, the relatively rare translations of basic science findings to clinical appli

Asymmetric vestibular function in the elderly might be a significant contributor to hip fractures

The aim of this study was to assess postural control, vestibular symmetry and health status in otherwise healthy hip fracture subjects and compare these factors with controls. The fracture subjects were recruited from 113 consecutive patients operated 12-33 months earlier. Nineteen of those were otherwise healthy and fulfilled the inclusion criteria. They were assessed and compared with 28 age- an

Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic Transition

During development, hematopoietic cells originate from endothelium in a process known as endothelial-to-hematopoietic transition (EHT). To study human EHT, we coupled flow cytometry and single-cell transcriptional analyses of human pluripotent stem cell-derived CD34(+) cells. The resulting transcriptional hierarchy showed a continuum of endothelial and hematopoietic signatures. At the interface of

Multilingual Spaces : Language Practices in English Classrooms. A Project Presentation

This paper presents a project that recently received funding from the Swedish Research Council. Data collection will begin in autumn 2017, focusing on language practices in multilingual English classroom spaces in Swedish secondary schools. While English is the normal medium of instruction in lessons, research in bilingual educational settings shows that judicious switches between pupils’ mother t

Development and verification of a pharmacokinetic model to optimize physiologic replacement of rhIGF-1/rhIGFBP-3 in preterm infants

Background:rhIGF-1/rhIGFBP-3 is being investigated for prevention of retinopathy of prematurity in extremely preterm infants.Methods:A population pharmacokinetic model was developed using data from phase I/II (Sections A-C) trials of rhIGF-1/rhIGFBP-3 and additional studies in preterm infants to predict optimal dosing to establish/maintain serum IGF-1 within physiological intrauterine levels. In S

Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia

Levodopa treatment is the major pharmacotherapy for Parkinson's disease. However, almost all patients receiving levodopa eventually develop debilitating involuntary movements (dyskinesia). Although it is known that striatal spiny projection neurons (SPNs) are involved in the genesis of this movement disorder, the molecular basis of dyskinesia is not understood. In this study, we identify distinct

Preclinical models of levodopa-induced dyskinesia

L -DOPA-induced dyskinesia (LID) represents one of the major limitations in the current pharmacotherapy of Parkinson's disease (PD) and affects the majority of PD patients. Animal models are the most important preclinical tool for molecular investigations of LID mechanisms and therapeutic targets. Over the last two decades, models of LID have been developed in both nonhuman primate and rodent spec