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The androgen receptor (AR) is the central determinant of prostate tissue identity and differentiation, controlling normal, growth-suppressive prostate-specific gene expression 1 . It is also a key driver of prostate tumorigenesis, becoming "hijacked" to drive oncogenic transcription 2-5 . However, the regulatory elements determining the execution of the growth suppressive AR transcriptional progra
We have generated two reporter plasmids that either monitor expression of human papillomavirus type 16 (HPV16) E2 mRNAs using splice site SA2709 or HPV16 E1C mRNAs utilizing splice site SA2582. In plasmid pE2sLuc, the entire E2 open reading frame was replaced by the secreted luciferase (sLuc) reporter gene and in the pE1nLuc plasmid the E1/E1C open reading frame was fused in frame with the nanoluc
Extreme value theory has been receiving much attention of late for proactively estimating crash risk through a two-step procedure that first samples extreme traffic conflicts and then estimates crash risk based on those sampled extremes. Although the existing body of research has encapsulated sampling methods within a predominant conventional technique, there is no universally accepted practice on
UNLABELLED: Cancer cells exhibit phenotypical plasticity and epigenetic reprogramming, which allows them to evade lineage-dependent targeted treatments by adopting lineage plasticity. The underlying mechanisms by which cancer cells exploit the epigenetic regulatory machinery to acquire lineage plasticity and therapy resistance remain poorly understood. We identified Zinc Finger Protein 397 (ZNF397
Swedish small-scale fishing has undergone significant changes over time. There are examples of small-scale fishers who have diversified their activities by developing new sales channels or by processing a large part of their products themselves. However, this type of activity is significantly less well-documented than the fishing itself. In this paper, we examine how the catches of the Swedish sma
BACKGROUND: Prostate cancers featuring an expansile cribriform (EC) pattern are associated with worse clinical outcomes following radical prostatectomy (RP). However, studies of the genomic characteristics of Gleason pattern 4 subtypes are limited.OBJECTIVE: To explore transcriptomic characteristics and heterogeneity within Gleason pattern 4 subtypes (fused/poorly formed, glomeruloid, small cribri
The operation of instruments and detectors in laboratory or beamline environments presents a complex challenge, requiring stable operation of multiple concurrent devices, often controlled by separate hardware and software solutions. These environments frequently undergo modifications, such as the inclusion of different auxiliary devices depending on the experiment or facility, adding further compl
DN DEBATT.En vecka före valet 2022 kallade dåvarande regeringen till en dramatisk pressträff om en påstådd elkris. I efterhand syns det ha varit ett politiskt konstruerat nödläge, som hämtat ur Trumps handbok. En oberoende granskning behövs nu för att minska risken att nuvarande regeringen gör samma sak, skriver Lars Jonung, ekonomiprofessor emeritus.
Introduction: Individuals with Panic Disorder with or without Agoraphobia (PD/A) suffer from high rates of comorbidity. The present study aimed to address a knowledge gap about whether psychiatric comorbidity at baseline differentially influences, or moderates, outcomes in PD/A focused treatments.Methods: Data were drawn from a doubly-randomized preference trial of Panic Control Therapy (PCT) and
Background: Midwifery continuity of care (MCoC) is a key aspect of woman-centred midwifery care, associated with improved outcomes for both women and midwives. In many countries, maternity care is fragmented, and MCoC uncommon in clinical practice and midwifery education. To address this gap, a pedagogical project entitled “Midwifery Student All the Way” was introduced in a midwifery programme in
Introduction: Excessive worry is common during adolescence and across a range of psychiatric conditions. There is a growing evidence base for the efficacy of cognitive behaviour therapy (CBT) in reducing the frequency of excessive worrying as a primary outcome in the context of clinical trials of youth with generalized anxiety disorder, and as a secondary outcome in trials of CBT for youth with ob
Reliable and cost-effective operation of structural systems over their service life depends on the implementation of Structural Health Monitoring (SHM) and maintenance activities, which influence operational costs, the expected costs of failure and downtime. Decision Value Analysis (DVA) provides a framework to quantify the value of such activities by evaluating their effect on total expected life
Nickel-based catalysts are the most promising alternative to replace platinum in hydrogen conversion devices in alkaline media. One approach to narrowing the performance gap between Pt and Ni is to fine-tune the nickel surface coverage by (hydr) oxide (NiOxHy) species, which determines its electrocatalytic activity for the hydrogen oxidation (HOR) and hydrogen evolution (HER) reactions. As Ni easi
Individuals who self-harm are often insensitive to pain, and consequently pain sensitivity has been proposed as a barrier for self-harm. It is unclear how pain and self-harm interplay in real life settings, and to what extent genetics and environmental factors contribute to the etiology of both. This study was registry based using classical twin design. A cohort of 16 948 Swedish twin pairs born b
This article explores constructions of voluntariness in Swedish district court judgments in child rape cases involving young people in romantic relationships. Drawing on youth research and feminist legal theory, we conducted a reflexive thematic analysis of 38 judgments involving complainants aged 13–14 and defendants aged 15–20. Our analysis resulted in three themes. First, voluntariness was cons
Introduction: Early-life determinants of middle-age cardiovascular health are poorly understood. This study examines associations of BMI and physical fitness in male adolescents with cardiovascular health measured by the Life's Essential 8 score in middle age. Methods: A population-based cohort study linked BMI and physical fitness from the Swedish Military Conscription Register (men conscripted f
