Filtyp
Dysfunctional insulin secretion is a hallmark of type 2 diabetes (T2D). Interestingly, several islet microRNAs (miRNAs) are upregulated in T2D, including miR-132. We aimed to investigate whether in vivo treatment with antagomir-132 lowers expression of miR-132 in islets thereby improving insulin secretion and lowering blood glucose. Mice injected with antagomir-132 for 24 h, had reduced expression
Tack vare ett näst intill oändligt antal variationer så har proteiner blivit naturens standardlösning för diverse uppgifter och problem. I våra egna kroppar har vi en uppsjö av olika varianter där några är allmänt välkända, t.ex. hemoglobin i våra röda blodkroppar som transporterar runt syre och insulin vilket sänker vår blodsockernivå. Andra proteiner är mer okända men trots det lika viktiga, exeThe behavior of concentrated protein solutions is of general high interest due to implications in, for example, biological systems and medical applications. It is necessary to investigate the rheological properties of such systems to understand how parameters, such as stability, are affected by the high concentrations. Unfortunately, studies are often hindered by the lack of sufficient quantities
It is well known that marine fish dynamics relate with climate variability, and predicting future population developments have become increasingly urgent with on-going climate change. One approach in widespread populations is to study how individuals from different parts of the distribution area respond to climate, thereby testing for potential resilience in terms of local adaptions against enviro
Charophytes play a critical role for the functioning of shallow lake ecosystems. Although growth of charophytes can be limited by many factors, such as temperature, nutrients and light availability, our understanding about concomitant effects of climate warming and other large-scale environmental perturbations, e.g. increases in humic matter content (‘brownification’) is still limited. Here we con
Most current results on coverage control using mobile sensors require that one partitioned cell is associated with precisely one sensor. In this paper, we consider a class of coverage control problems involving higher order Voronoi partitions, motivated by applications where more than one sensor is required to monitor and cover one cell. Such applications are frequent in scenarios requiring the se
Inclusive ϒ(1S) and ϒ(2S) production have been measured in Pb–Pb collisions at the centre-of-mass energy per nucleon–nucleon pair sNN=5.02 TeV, using the ALICE detector at the CERN LHC. The ϒ mesons are reconstructed in the centre-of-mass rapidity interval 2.5
This research investigates the daylight regulation compliance of existing multi-family housing developments located primarily in Stockholm (Lat.: 59,33 °N), Sweden. A representative sample of 54 buildings consisting of 10.888 individual rooms was modelled according to archived documentation drawings and evaluated by use of Radiance simulations, to test their compliance with the current Swedish day
Femtosecond (fs)-laser electronic-excitation tagging velocimetry (FLEET) in a nitrogen flow field using a 267 nm laser was performed under the condition of fs-laser filamentation. The filamentous properties and their effects on velocity measurements were investigated and were compared with those of an 800 nm fs-laser. The results show that the required energy of the 267 nm laser pulse is as low as
A binocular eye tracker needs to be accurate to enable the determination of vergence, distance to the binocular fixation point and fixation disparity. These measures are useful in e.g. the research fields of visual perception, binocular control in reading and attention in 3D. Are binocular pupil-based video eye trackers accurate enough to produce meaningful binocular measures? Recent research reve
Background: Fish contains methylmercury (MeHg) which can cause oxidative stress and neurodevelopmental toxicity at sufficiently high doses. Fish also contains polyunsaturated fatty acids (PUFA) which have both antioxidant (n-3) and oxidant (n-6) properties. Mitochondrial DNA (mtDNA) is sensitive to oxidative stress but has not been previously studied in relation to MeHg exposure or PUFA status. Ob
DN Debatt: Sverige har åtagit sig att skydda 20 procent av landets land- och sötvattensområden till 2020. Men hittills har bara 4–5 procent av den omfattande produktiva skogen bevarats. För att nå de demokratiskt beslutade målen måste Skogsstyrelsens beslut om stopp för inventering av nyckelbiotoper hävas, skriver sju forskare.
Collective effects are observed in high-multiplicity pp events, similar to the signals traditionally attributed to the formation of a Quark Gluon Plasma in heavy ion collisions. In core–corona models it is assumed that a partial plasma formation is indeed possible also in pp, but here the focus is on several recent models that attempt to explain pp data without invoking plasma formation. These att
Correct diagnosis of pulmonary tumors is essential for treatment decision and often relies on immunohistochemical markers. We stained tissue microarrays from resected primary lung cancer (n = 665) and pulmonary metastases (n = 425) for CK7, CK20, CDX2, CK5, p40, p63, TTF-1, napsin A, GATA3, and PAX8 to systematically assess the diagnostic value of these markers. Primary lung adenocarcinomas expres
BACKGROUND: Many studies have indicated that colon and rectal cancers differ in etiology and histology. OBJECTIVE: The aim of this study was to investigate whether the associations of colon and rectal cancers with any other (discordant) cancer were site specific. DESIGN: A novel approach was implemented in which cancer risks were analyzed in families with increasing numbers of family members diagn
