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Endotoxemia-induced inflammation has been associated with insulin resistance and atherosclerosis, ultimately increasing the risk of coronary heart disease. Increased intestinal permeability is an important event leading to endotoxemia. This study aims to elucidate the possible association between endotoxin (lipopolysaccharide) and zonulin (a biomarker of intestinal permeability) levels and the ris

We use data from the Radial Velocity Experiment (RAVE) and the Tycho-Gaia astrometric solution (TGAS) catalogue to compute the velocity fields yielded by the radial (VR), azimuthal (Vϕ),and vertical (Vz) components of associated Galactocentric velocity. We search in particular for variation in all three velocity components with distance above and below the disc midplane, as well as how each compon

The education–fertility relationship is a central element of the models explaining the transition to sustained economic growth. But many determinants of this relationship have not yet received more systematic attention. In this paper, we apply a three-stages least-squares estimator on French county-level data, including newly collected data, to better understand the causal effects running from edu

Among the founders of French psychology, Pierre Janet (1859 –1947) is recognized forboth his scientific and institutional roles. The psychology born at the turn of the 20thcentury was initially partly receptive to, but then engaged in, a battle with the “psychical marvelous,” and Janet was no exception. He was involved in the split between psychology and parapsychology (or “metapsychics” in France

Förmågan att uppfatta ljus och vilken riktning det kommer från är utomordentligt användbart för djur. Därför är det inte förvånande att denna förmåga återfinns hos i stort sett varje större djurgrupp, även bland de som anses enkla, såsom koraller och spolmaskar. Endast några få djurgrupper har dock, under evolutionens gång, utvecklat verkligt bra ögon som snabbt kan identifiera objekt av djurens eLight-detection provides incomparabaly rapid information at a range of time scales and, consequently, directional photoreception is found in almost every major metazoan clade. Conversely, a much smaller cohort have evolved sophisticated high resolution vision, which facillitates complex tasks via the detection of fast or small objects,. such as courtship and high-speed pursuit of prey. A few such

BACKGROUND AND AIM Non-stop stair ascending at maximum speed is required to reach a safe refuge level from deep underground structures, such as subways and in high-rise buildings in an emergency evacuation situation. Endurance of stair climbing and identifying the time of the onset of leg’s local muscle fatigue (LMF) are interests in evacuation research. The objective of this laboratory study was

While the simple-system flute was primarily developed as a product of 19th century Western art music, it has since become established in other genres and traditions. The aim of the present study is to explore approaches towards the simple-system flute as it is used across genres and traditions today. These approaches are understood from the performers point of view, and focus on the relationship b

Social interaktion sker ofta i grupper. För barn är skolklassen en grupp de dagligen interagerar i. Skolklassen och den sociala interaktion som sker i skolan har stor betydelse för barns välmående och framtida sociala interaktioner. Lärarna i skolan har därför i uppdrag att arbeta med barns sociala samspel och mot kränkande behandling. Avhandlingens övergripande syfte att öka förståelsen för barnsSocial interaction often takes place in groups. The school class is an important group in which children interact. Children spend a large percentage of their day with their classmates in school and classmates are not only co-workers, but also individuals interacting socially as friends. Several studies show that social interaction and friendship in school effect children’s wellbeing, academic perf

Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL) rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remains unclear. Using a retroviral acute myeloid mouse leukemia model, we demonstrate that FLT3 ITD, FLT3 N676K, and NRAS G12D accelerate KMT2A-MLLT3 leukemia onset. Further, also subclonal FLT3 N676K mutations accelerate

Time-dependent ensemble averages, i.e., trajectory-based averages of some observable, are of importance in many fields of science. A crucial objective when interpreting such data is to fit these averages (for instance, squared displacements) with a function and extract parameters (such as diffusion constants). A commonly overlooked challenge in such function fitting procedures is that fluctuations

Conscription forces young men to serve in the military, irrespective of their opportunity costs. Using random assignment in the Danish draft lottery, we find a negative average effect of peacetime military service on earnings, an effect varying by ability, with high-ability men facing a $23,000 lifetime earnings penalty but with low-ability men facing none. This gradient is robust to different mea

Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise sialylated environments deploy specific transporters to mediate import of scavenged sialic acids. Here, we report a substrate-bound 1.95 Å resolution structure and subsequent characterisation of SiaT, a sialic acid transporter from Proteus

This thesis explores musical composition in the context of contemporary theatre. It suggests methods where compositional thinking – broadly understood – can be used as a dramaturgical device in the creation of theatre performances. Such musicalization of theatre provides new methods for an artistic practice and questions traditional artistic hierarchies and working structures. The investigation de

Genomgång av filmer om Winston Churchill.

Utvecklingen inom gentekniken har gjort det möjligt att inom sjukvårdens ram undersöka många gener samtidigt genom helgenom-/helexomanalyser. Detta har hittills främst utnyttjats för diagnostik av personer, framför allt barn, med misstänkt ärftliga syndrom.Under de senaste tre åren har tekniken utnyttjats för att bygga upp plattformar att användas för kartläggning av recessiva sjukdomsanlag hos frDue to recent advances in molecular genetic testing, massive parallel sequencing has become possible at an affordable cost for health care. Thus, it is now possible to test healthy young persons for carriership of mutations in many genes for severe recessive genetic conditions – extended genetic carrier testing. The introduction of this test in Swedish health care must be accompanied by ethical co

Dynamic isotropy is a condition where eigenfrequencies of a robot are equal, which could be equivalent to the maximization of the lowest eigenfrequency. Accordingly, dynamic isotropy can be considered as an effective criterion to optimize dynamic performance of a robot. In this paper, we firstly present the mathematical conditions in order to obtain dynamic isotropy in hexapods. These conditions a

BACKGROUND: A well-functioning immune defence is crucial for fitness, but our knowledge about the immune system and its complex interactions is still limited. Major histocompatibility complex (MHC) molecules are involved in T-cell mediated adaptive immune responses, but MHC is also highly upregulated during the initial innate immune response. The aim of our study was therefore to determine to what

Migration is energetically demanding and physiologically challenging. Migrating birds, for example, need to boost their antioxidant defenses to defeat the pro-oxidants produced during high energetic activity. The enhanced antioxidant defense possibly withdraws limited resources (e.g., energy or micronutrients) from other physiological functions, such as immune defense. Such a trade-off might not o

Accountability to stakeholders has always been pivotal in supporting nonprofit organizations in legitimizing their existence within local communities and building public trust. The development of Web-based accountability tools has offered growing possibilities to communicate and engage in dialogue with stakeholders. However, nonprofit organizations are not yet fully exploiting the potential of the

The development of gluten-free pasta with functional characteristics is an important strategic area for the food industry. The objective of this study was to evaluate the influence of the polyphenols present in blue maize flour (BMF) on the antioxidant properties and starch digestibility of composite gluten-free pasta. Composite pasta was prepared with 25, 50, or 75% BMF in a laboratory-scale proc