Several disease-linked mutations of apolipoprotein A-I, the major protein in high-density lipoprotein (HDL), are known to be amyloidogenic, and the fibrils often contain N-terminal fragments of the protein. Here, we present a combined computational and experimental study of the fibril-associated disordered 1-93 fragment of this protein, in wild-type and mutated (G26R, S36A, K40L, W50R) forms. In a

Using Monte Carlo methods, we explore and compare the effects of two protein crowders, BPTI and GB1, on the folding thermodynamics of two peptides, the compact helical trp-cage and the β-hairpin-forming GB1m3. The thermally highly stable crowder proteins are modeled using a fixed backbone and rotatable side-chains, whereas the peptides are free to fold and unfold. In the simulations, the crowder p

We describe and test an implicit solvent all-atom potential for simulations of protein folding and aggregation. The potential is developed through studies of structural and thermodynamic properties of 17 peptides with diverse secondary structure. Results obtained using the final form of the potential are presented for all these peptides. The same model, with unchanged parameters, is furthermore ap

En vanlig uppfattning är att självskadebeteende ofta fungerarsom emotionsreglering. Men vad är det för emotioner somregleras på detta sätt? Och varför har dessa personer valt justdenna form av emotionsreglering? Syftet med denna artikel äratt diskutera dessa frågor utifrån aktuell forskning. Forskningmed ekologiska metoder tyder på att självskadebeteendet framförallt är ett sätt att uttrycka och r

Background: Randomized controlled trials (RCTs) are considered the best methodology for studying the efficacy of psychotherapy. Optimally an RCT design makes it possible to conclude that if one treatment has a better outcomethan another, this is due to the treatment package (TP) as it was implemented in this particular context, rather than other factors beyond the treatment (= high internal validi

We use high-resolution simulations of isolated dwarf galaxies to study the physics of dark matter cusp-core transformations at the edge of galaxy formation: M200 = 107-109 M⊙. We work at a resolution (~4 pc minimum cell size; ~250 M⊙ per particle) at which the impact from individual supernovae explosions can be resolved, becoming insensitive to even large changes in our numerical 'sub-grid' parame

We use cosmological zoom-in simulations of galaxy formation in a Milky-Way-sized halo started from identical initial conditions to investigate the evolution of galaxy sizes, baryon fractions, morphologies, and angular momenta in runs with different parameters of the star formation-feedback cycle. Our fiducial model with a high local star formation efficiency, which results in efficient feedback, p

We investigate the star formation-feedback cycle in cosmological galaxy formation simulations, focusing on the progenitors of Milky Way (MW)-sized galaxies. We find that in order to reproduce key properties of the MW progenitors, such as semi-empirically derived star formation histories (SFHs) and the shape of rotation curves, our implementation of star formation and stellar feedback requires (1)

We investigate the momentum and energy budget of stellar feedback during different stages of stellar evolution, and study its impact on the interstellar medium (ISM) using simulations of local star-forming regions and galactic disks at the resolution affordable in modern cosmological zoom-in simulations. In particular, we present a novel subgrid model for the momentum injection due to radiation pr

Observations of high-redshift galaxies have revealed a multitude of large clumpy rapidly star-forming galaxies. Their formation scenario and their link to present-day spirals are still unknown. In this Letter, we perform adaptive mesh refinement simulations of disc formation in a cosmological context that are unrivalled in terms of mass and spatial resolution. We find that the so-called 'chain-gal

Svår fetma är ett svårbehandlat tillstånd och hittills har fetmakirurgi visat sig vara den metod som ger den största och mest beständiga viktminskningen över längre tid. Fetmakirurgi har tidigare endast erbjudits vuxna både i Sverige och i andra länder. Under senare år har fetmakirurgi börjat prövas som ett behandlingsalternativ till ungdomar med svår fetma där annan behandling inte har gett tillrBariatric surgery is tried out as a new treatment option for adolescents with severe obesity. Little is known about outcomes in mental health in adolescents who undergo weight loss surgery.The 3 studies in this thesis assess mental health in adolescents before, and after 4 months, 1 year and 2 years after undergoing gastric bypass. The studies are part of the Swedish national AMOS study and all ad

While previous research has demonstrated that gaze position can increase the accessibility of previous memories (Johansson & Johansson, 2014), the present study tested whether such gazes can assist in selecting target memories at the expense of competing memories. An adapted retrieval practice paradigm was used, where participants engaged in repeated selective retrieval while looking at locati

We demonstrate that pupillometry can be used to track memory interference independent of explicit responses. Pupil diameter was recordedthroughout encoding and retrieval of words from the same category over 4 trials, causing buildup of proactive interference (PI). In a contrastingcondition, the category was switched on the 4th trial, causing release from interference (RI). Pupil dilation systemati

Several studies have reported that spontaneous eye movements occur when visuospatial information is recalled from memory. Such gazes closely reflect the content and spatial relations from the original scene layout (e.g., Johansson et al., 2012). However, when someone has originally read a scene description, the memory of the physical layout of the text itself might compete with the memory of the s