In 1985, the surgical team led by Bjarne Semb implanted the first total artificial heart (TAH) in Europe, and the following year the first successful bridge to transplant in Europe using the Symbion J-7/100 TAH. Together with the clinical experiences of colleagues in the United States, these early cases preceded the subsequent development of scores of mechanical assist devices to treat advanced he

Vegetation is the main component of the terrestrial Earth, and it plays an imperative role in carbon cycle regulation and surface water/energy exchange/balance. The coupled effects of climate change and anthropogenic forcing have undoubtfully impacted the vegetation cover in linear/non-linear manners. Considering the essential benefits of vegetation to the environment, it is vital to investigate t

Digital platforms have deeply transformed a wide variety of sectors. However, new platform business models often face critical legitimacy challenges. Consequently, new entrants must continuously design and redesign their business model components, particularly when entering non-platformized sectors that are highly regulated. We draw on a longitudinal case study of the emergence of digital healthca

Binary star systems are assumed to be co-natal and coeval, and thus to have identical chemical composition. In this work, we aim to test the hypothesis that there is a connection between observed element abundance patterns and the formation of planets using binary stars. Moreover, we also want to test how atomic diffusion might influence the observed abundance patterns. We conduct a strictly line-

The study of plant mitochondria started in earnest around 1950 with the first isolations of mitochondria from animal and plant tissues. The first 35 years were spent establishing the basic properties of plant mitochondria and plant respiration using biochemical and physiological approaches. A number of unique properties (compared to mammalian mitochondria) were observed: (i) the ability to oxidize

Background. Heart transplantation (HT) remains the ultimate final therapy for patients with end-stage heart failure. To prevent rejection of the allograft, life-long immunosuppressive therapy is required. As survival after HT has improved over the past decades, long-term complications, such as chronic kidney disease (CKD) and osteoporosis, are of increasing importance for morbidity and mortality.

Bones have unique mechanical properties that originate from their main constituents: mineral, in the form of hydroxyapatite (HAp) crystals, and collagen type-I. The stiffness of the HAp mineral combined with the flexibility of collagen, and their intricate hierarchical arrangement from the smallest individual building blocks to the organ level, result in a composite tissue with a remarkable abilit

Large carnivores are controversial species, and associated conflicts between stakeholders with opposing views on large carnivores are observed across the globe. Social trust, the public’s willingness to rely on those responsible for developing policies, has gained much attention regarding the acceptance of large carnivores and large carnivore management. However, trust in large carnivore science h