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Induction of donor-specific tolerance to islet allografts in nonhuman primates.

Pancreatic tissue grafting is by far the most physiological therapeutic solution to the insulin deficiency of diabetes. Recent clinical trials have indicated somewhat successful use of nonsteroidal immunosuppressive regimens and a successful nonhuman primate trial using CD154 for costimulation blockade was reported. However, these protocols need to be replaced with safe and efficacious ones in whi

High-pressure chamber measurements

Results from the design of a high-pressure chamber and its components, recently developed at the Lund Institute of Technology, are presented. The results show that at high pressures, when the lubricants have solidified, the density varies linearly with the pressure and the shear strength also increases nearly linearly with pressure. This is also true for the investigated gasses when they are compr

ATPase activity of magnesium chelatase subunit I is required to maintain subunit D in vivo

During biosynthesis of chlorophyll, Mg2+ is inserted into protoporphyrin IX by magnesium chelatase. This enzyme consists of three different subunits of approximate to 40, 70 and 140 kDa. Seven barley mutants deficient in the 40 kDa magnesium chelatase subunit were analysed and it was found that this subunit is essential for the maintenance of the 70 kDa subunit, but not the 140 kDa subunit. The 40

Cadmium-induced effects on bone in a population-based study of women

High cadmium exposure is known to cause bone damage, but the association between low-level cadmium exposure and osteoporosis remains to be clarified. Using a population-based women's health survey in southern Sweden [Women's Health in the Lund Area (WHILA)] with no known historical cadmium contamination, we investigated cadmium-related effects on bone in 820 women (53-64 years of age). We measured

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Popular Abstract in Swedish Avhandlingens mål är att undersöka relationen mellan mentala representationer – ‘konceptuella strukturer’ – och deras språkliga form. En sådan undersökning förutsätter en analys inte bara av utomspråkliga representationsnivåer utan även av nivåer som är i sig språkliga. Komplexiteten i förhållandet mellan konceptuella strukturer och den språkliga formen är uppenbar på dThe aim of this thesis is to investigate the relation between intrasubjective mental representations – ‘conceptual structures’ – and their intersubjectively available material manifestation, in particular morphosyntactic representations. Such an investigation presupposes the analysis of not only extralinguistically established modules but also of structural levels that are inherent components of t

Absorption Characteristics of Periodically Perforated Suspended Ceilings

Popular Abstract in Swedish I innemiljöer är ofta innertaken nedsänkta för att ge plats åt elinstallationer, ventilationsdon och dylikt. Om innertaken från början består av plattor som reflekterar ljud, så kan dessa perforeras och förses med porösa skikt, och därmed även användas som ljudabsorbenter. Mekanismerna för denna ljudabsorption är i princip välkänd, men det tillkommer bland annat en del The sound absorption characteristics of resonant absorbers, implemented as perforated suspended inner ceilings attached with thin porous layers, are investigated. Several existing theories model the principal absorption mechanisms, but the interaction with the outer sound field influences the absorption in ways that can be modelled with new approaches. The effect of arranging the absorbing surfac

Design and Implementation of Object-Oriented Model Libraries using Modelica

Popular Abstract in Swedish Matematiska modeller och simulering är viktiga verktyg för att hantera tekniska system. Trenden idag är att öka komplexiteten i system genom integrerad produktion och processoptimering. Att hantera dessa komplexa system kräver kunskaper inom många områden samtidigt. Modellbibliotek är ett bra sätt att paketera kunskap. Kommersiella simuleringsprogram tillandahåller bra This thesis describes basic models for thermo-fluid systems and the implementation of the models using a flexible object-oriented structure in the ThermoFluid library. Model libraries provide an excellent way to package engineering knowledge of systems to be reused by non-experts. Many commercial simulation packages provide good model libraries, but they are usually domain specific and closed. Mod

Framväxten av en diagnos--synen på psykiska krigsreaktioner under 1900-talet med fokus på FN-svenskarna i Kongo 1960 - 64

Psychiatric casualties among soldiers constitute an inevitable part of modem warfare. For the past hundred years Medicine and Society have shown a growing interest in the combat reactions. The focus has shifted from an organic one towards a psychological and psychiatric perspective. Cultural, social, economical and political forces have influenced the scientific development from the Shell shock to

Health-related quality of life and its potential prognostic implications in patients with aggressive lymphoma: a Nordic Lymphoma Group Trial

This study was conducted to explore treatment and disease-related effects on health-related quality of life (HRQoL) in patients with aggressive lymphoma, to identify predictors for impaired long-term HRQoL, and to analyze the prognostic value of pretreatment HRQoL. Ninety-five patients with aggressive lymphoma, constituting a subset of a randomized multicenter trial comparing CHOP and MACOP-B, ent

SAGBI bases under composition

Polynomial composition is the operation of replacing the variables in a polynomial with other polynomials. In this paper we give a sufficient and necessary condition on a set Theta of polynomials to assure that the set F circle Theta of composed polynomials is a SAGBI basis whenever F is.

Tools for Autonomous Process Control

There is an ongoing trend towards higher automation level in process control systems. The purpose of a plant is to manufacture some product at a high production rate with a consistent quality, while minimizing the use of resources in terms of energy consumption, raw material and labor. With a higher degree of autonomy in the control system, it is possible to improve all these aspects, thus increas

Selecting matched root architecture in tree pairs to be used for assessing N-2 fixation based on soil-(15) N-labelling

It is commonly assumed that soil-N-15-labelling provides reliable estimates of N-2 fixation in trees by matching N-2-fixing and non-N-2-fixing tree pairs. As root system is a key parameter in determining suitability of the tree pairs, we compared root architecture of Acacia cyanophylla Lindl. and Casuarina glauca Sieber ex. Spreng. (two N-2-fixing trees) with Eucalyptus camaldulensis Dehn. and Cer

Traffic-generated emissions of ultrafine particles from pavement-tire interface

In a road simulator study, a significant source of sub-micrometer fine particles produced by the road-tire interface was observed. Since the particle size distribution and source strength is dependent on the type of tire used, it is likely that these particles largely originate from the tires, and not the road pavement. The particles consisted most likely of mineral oils from the softening filler

Protein microchip bioassay with dual fluorescent- and MALDI read-out.

Protein Microchip Array technology makes it possible to examine patterns of protein expressions and modifications. Current technologies such as two-dimensional get electrophoresis (2-DE) in combination with mass spectrometry allows the identification of biologically relevant proteins with high resolving power, but has also considerable limitations. Most spots observed in 2-DE are from high abundan