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Hippocampal Function Is Impaired by a Short-Term High-Fat Diet in Mice: Increased Blood–Brain Barrier Permeability and Neuroinflammation as Triggering Events

Worldwide, and especially in Western civilizations, most of the staple diets contain high amounts of fat and refined carbohydrates, leading to an increasing number of obese individuals. In addition to inducing metabolic disorders, energy dense food intake has been suggested to impair brain functions such as cognition and mood control. Here we demonstrate an impaired memory function already 3 days

Promoting nature-based solutions: Guideline for integrating ecosystem-based adaptation into municipal planning and governance

Det här dokumentet ger lokala politiker och tjänstemän ett processorienterat verktyg för att stärka förankringen (integreringen) av ekosystembaserad klimatanpassning i relevanta sektorer av kommunal verksamhet. Guiden presenterar systematiskt de nivåer och områden där förankring av ekosystembaserad klimatanpassning är viktigt, och möjliggör på så sätt planering och bedömning av åtgärder. Det övergThis guideline offers local government officers and local politicians process‐oriented assistance for integrating ecosystem‐based adaptation within relevant sectors of municipal administration with the aim of fostering sustainable urban development. It is thus an instrument to support leadership of this integration process. The levels and areas where integration of ecosystem‐based adaptation isrel

Forskning om svensk forskarutbildning åren 2000–2020

I denna forskningsöversikt kartläggs svenskproducerad och kvalitetsgranskad forskning om svensk forskarutbildning i syfte att illustrera forskningsfältets fysiska och vetenskapliga formering 2000–2020. Databasen Swepub användes för att identifiera licentiatavhandlingar, doktorsavhandlingar och refereegranskade artiklar som sedan analyserades med deskriptiv statistik och tematisk analys. Fältets fyIn this scoping review we map Swedish research on Swedish doctoral education in order to illustrate the physical and scientific configuration of the field from 2000 to 2020. The database Swepub was used to identify licentiate theses, doctoral theses, and peer reviewed articles. Subsequently the material was analysed through descriptive statistics and thematic analysis. The physical configuration o

Prospective association between dietary pesticide exposure profiles and type 2 diabetes risk in the NutriNet-Santé cohort

BackgroundStudies focusing on dietary pesticides in population-based samples are scarce and little is known about potential mixture effects. We aimed to assess associations between dietary pesticide exposure profiles and Type 2 Diabetes (T2D) among NutriNet-Santé cohort participants.MethodsParticipants completed a Food Frequency Questionnaire at baseline, assessing conventional and organic food co

Cardiac Long-Axis Function. Experimental and Clinical Aspects.

This thesis includes both experimental and clinical projects. The experimental studies investigate pathophysiological aspects of ventricular longitudinal function and therapeutic hypothermia during acute myocardial infarction (AMI). The clinical projects investigate the ability of ventricular longitudinal function variables to predict mortality and morbidity in patients with heart failure and redu

Access-Based Consumption in the Built Environment: Sharing Spaces

The pressing need to implement a more circular economy has led to advancements in the research field. In the spatial context, sharing spaces and access-over-ownership models have the potential to mitigate the detrimental environmental impacts of space use. This study aims to adapt an existing theoretical framework on access-based consumption to the spatial context. We utilise a qualitative case st

Mechanosensitive transcriptional regulation of gene expression in smooth muscle. Implications for health and disease

Smooth muscle participates in forming the wall of hollow organs, tracts, and blood vessels. Therefore, it plays a critical role in mediating vital functions in the body including regulation of blood pressure. In response to changes in the surrounding microenvironment, smooth muscle cells can modulate their phenotype and dedifferentiate from being quiescent contractile to a more proliferative and m

Modeling Media History : On topic models of Swedish media politics 1945–1989

In an explorative manner, this article uses a data-driven digital history set-up to focus on media political issues in Sweden during the second half of the twentieth century. By distant reading and topic modeling a dataset of 3100 Swedish Government Official Reports between 1945 and 1989—a corpus of some 87 million tokens—the article gives a new perspective of how the Swedish state examined and di

A Literature Review and Meta-Analysis of the Effects of Lockdowns on COVID-19 Mortality – II

The purpose of this systematic review and meta-analysis is to determine the effect of lockdowns on COVID-19 mortality based on available empirical evidence. Lockdowns are defined as the imposition of at least one compulsory, non-pharmaceutical intervention (NPI). We employ a systematic search and screening procedure in which 19,646 studies are identified that could potentially address the purpose

Eye-movement replay supports episodic remembering

When we bring to mind something we have seen before, our eyes spontaneously unfold in a sequential pattern strikingly similar to that made during the original encounter, even in the absence of supporting visual input. Oculomotor movements of the eye may then serve the opposite purpose of acquiring new visual information; they may serve as self-generated cues, pointing to stored memories. Over 50 y

Novel methods of malignant brain tumor treatment utilizing the tumor microenvironment

Malignant brain tumors constitute a disaster in the lives of patients, either in the form of extremely low survival in glioblastoma, or the serious long-term adverse effects of therapy in medulloblastoma. These two tumor types represent the most common malignant brain entities in adults and children, respectively. Ever since the early 2000’s, no major improvement of patient outcomes occurred. Immu

Ovarian tumor frozen section, a multidisciplinary affair

BackgroundOvarian Cancer (OC) constitute the eighth most common cancers among women worldwide. Surgery remains the cornerstone in the management of OC. Intraoperative frozen section (FS) diagnosis is widely used to decide the surgery course. We aimed to assess the reliability of intraoperative FS diagnosis for treatment planning of patients with suspected OC from a multidisciplinary perspective. T