Epidemiological data indicate decreased risk for development and growth of abdominal aortic aneurysm (AAA) among patients with diabetes mellitus (DM). On the other hand, DM adds to increased cardiovascular (CV) morbidity and mortality. In a nationwide observational cohort study of patients registered in the Swedish Vascular Register and the Swedish National Diabetes Register, we evaluated potentia

Many state-of-the-art applications for linear accelerators, such as free-electron lasers (FELs) and plasma-wakefield accelerators (PWFAs), require small normalized emittances, and PWFAs in particular are very sensitive to transverse slice offsets along the beam. Dispersive systems, such as bunch compressors, can cause different chromatic aberrations, one of which yields transverse slice offsets. I

Maternal drug abuse during pregnancy is a rapidly escalating societal problem. Psychostimulants, including amphetamine, cocaine, and methamphetamine, are amongst the illicit drugs most commonly consumed by pregnant women. Neuropharmacology concepts posit that psychostimulants affect monoamine signaling in the nervous system by their affinities to neurotransmitter reuptake and vesicular transporter

There is a well-documented tension in many nonprofts - particularly those seeking government contracts or working in areas that compete with the private sector - between the institutional logics of business-market and nonproft-mission. This paper presents a case study of a century old Swedish nonproft. It suggests that in the presence of competing hybrid logics, organizational actors respond accor

The need to integrate climate change adaptation (CCA) considerations into disaster risk management (DRM) systems is widely recognised. However, successful integration, and thus the implementation of integrated planning measures, is difficult in practice. To understand and reduce the problems encountered, it is important to investigate systemic challenges. These challenges are rooted in the interac

Direct neuronal reprogramming can be achieved using different approaches: by expressing neuronal transcription factors or microRNAs; and by knocking down neuronal repressive elements. However, there still exists a high variability in terms of the quality and maturity of the induced neurons obtained, depending on the reprogramming strategy employed. Here, we evaluate different long-term culture con

Introduction: Differential patterns of brain atrophy on structural magnetic resonance imaging (MRI) revealed four reproducible subtypes of Alzheimer's disease (AD): (1) “typical”, (2) “limbic-predominant”, (3) “hippocampal-sparing”, and (4) “mild atrophy”. We examined the neurobiological characteristics and clinical progression of these atrophy-defined subtypes. Methods: The four subtypes were rep

In this paper an acoustofluidic system to trap hydrogel droplets is shown. The presented trapping method is label-free, biocompatible and operated in non-contact mode. The results show that the droplets can be trapped at flow rates up to 76 μL/min which corresponds to an average flow speed of 3.2 mm/s. Moreover, it is shown that the droplets can be trapped for several hours, thus allowing for stud

Först halvledarteknik, sedan nanoteknik. Tillsammans utgör de huvuddelen av det vi definierar som modern teknik. Användandet av halvledare revolutionerade teknologin under mitten av 1900-talet genom möjligheten att kunna kontrollera halvledarmaterial till att vara antingen elektriskt isolerande eller ledande. Inom elektroniken utgör halvledarna den viktigaste beståndsdelen i till exempel datorer, The topic of III-V nanowires is still, after more than two decades, a growing and lively research area. The areas of application are wide and contain such important topics as energy harvesting, cheap and efficient lighting, high efficiency detectors and new types of electronics. III-V materials offer properties superior to the widely used Si. They can have considerably higher carrier mobility whic

SummaryThe human pathogen Streptococcus pyogenes (GAS) causes both superficial infections, such as strep throat, and invasive infections, such as necrotizing fasciitis, and is responsible for about half a million deaths each year. The number of GAS infections have increased since the 1980’s, due to the emergence of a M1T1 strain that has become widely disseminated. Increased expression of Streptol

Background: The transcription factor signal transducer and activator of transcription 3 (STAT3) is implicated in cancer drug resistance, metastasis, and immunosuppression and has been identified as a promising therapeutic target for new anticancer drugs. Myeloid-derived suppressor cells (MDSCs) play a major role in the suppression of antitumor immunity and STAT3 is involved in the accumulation, ge

The unknown role of the carrier protein transthyretin (TTR) in mechanisms of functional recovery in the postischemic brain prompted us to study its expression following experimental stroke. Male C57/B6 mice (age 9 to 10 weeks) were subjected to permanent focal ischemia induced by photothrombosis (PT) and brain tissues were analyzed for ttr expression and TTR levels at 24 hours, 48 hours, 7 days an

The global anti-doping effort in sport is based upon perceptions of the system as desirable, proper and appropriate and thus considered legitimate. The legitimacy of the anti-doping system has earlier been studied bottom-up, based on the views of athletes. In order to gain greater understanding of legitimation processes, it is also important to study legitimation strategies top-down, used by decis

The causes and extent of regional inequality in the process of economic growth are at the core of historical economic research. So far, much attention has been devoted to studying the role of industrialization in driving regional divergence. However, empirical studies on relatively unequal countries such as Italy and Spain show that inequality was already high at the outset of modern industrializa

This paper revisits the Power Resource Theory (PRT) by testing one of its more influential claims: the relation between the strength of the labor movement and the reduction of industrial conflicts. Using panel data techniques to analyze more than 2,000 strikes in 103 Swedish towns we test whether a shift in the balance of power towards Social Democratic rule was associated with fewer strikes. The

Although morphology-based phylogenetic analyses and molecular data suggested that the cycloneuralians might have emerged in the Ediacaran Period, the oldest known fossil remains of cycloneuralians were first reported from the Cambrian Fortunian Stage of South China, and to date four genera and species as well as nine indeterminate forms have been described. Here, we report the latest discoveries o

In the search for low greenhouse gas propulsion, the dual fuel engine provides a solution to use low carbon fuel at diesel-like high efficiency. Also a lower emission of NOx and particles can be achieved by replacing a substantial part of the diesel fuel by for example natural gas. Limitations can be found in excessively high heat release rate (combustion-knock), and high methane emissions. These

The present work describes the numerical modeling of medium-speed marine engines, operating in a fumigated dual-fuel mode, i.e. with the second fuel injected in the ports. This engine technology allows reducing engine-out emissions while maintaining the engine efficiency and can be fairly easily retrofitted from current diesel engines. The main premixed fuel that is added can be a low-carbon one a