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Aspirin for Primary Stroke Prevention; : Evidence for a Differential Effect in Men and Women

Background: The use of aspirin for primary prevention of cardiovascular events in men and women remains controversial. Our study aimed to investigate the role of aspirin in primary stroke prevention in men and women and the effect of aspirin on risk of ischemic stroke in patients with covert cerebral small vessel disease (ccSVD).Methods: We performed systematic searches of the PubMed, and Cochrane

Diversity of Cytochrome c Oxidase Assembly Proteins in Bacteria

Cytochrome c oxidase in animals, plants and many aerobic bacteria functions as the terminal enzyme of the respiratory chain where it reduces molecular oxygen to form water in a reaction coupled to energy conservation. The three-subunit core of the enzyme is conserved, whereas several proteins identified to function in the biosynthesis of the common family A1 cytochrome c oxidase show diversity in

The properties and utility of less evaluative personality scales: Reduction of social desirability; increase of construct and discriminant validity.

Evaluative neutralization implies rephrasing items such that it is less clear to the respondent what would be a desirable response in the given population. The current research compares evaluatively neutralized scales measuring the FFM model with standard counterparts. Study 1 reveals that evaluatively neutralized scales are less influenced by social desirability. Study 2 estimates higher-order fa

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and phy

Perceptions, experiences and barriers to lifestyle modifications in first-generation Middle Eastern immigrants to Sweden : A qualitative study

Objective The prevalence of type 2 diabetes (T2D) among Iraqi immigrants to Sweden is high and partly related to sedentary physical activity and calorie dense food. The aim of the present study was to explore perceptions, experiences and barriers concerning lifestyle modifications (LSM) in Iraqi immigrants to Sweden at risk for T2D. Design A qualitative thematic analysis was conducted on data coll

Risk-Based Evaluation of Improvements in DrinkingWaterTreatment Using Cost-Benefit Analysis

Reliable and safe drinking water supply requires adequate risk management. Decisionsupport models can aid decisionmakers to effectively evaluate risk mitigation measures and allocatesocietal resources. Here, a Swedish case study illustrates how the installation of ultrafiltrationmembranes can be evaluated by combining risk assessment and cost-benefit analysis. Quantitativemicrobial risk assessment

Accurate Correction of the "bulk Response" in Surface Plasmon Resonance Sensing Provides New Insights on Interactions Involving Lysozyme and Poly(ethylene glycol)

Surface plasmon resonance is a very well-established surface sensitive technique for label-free analysis of biomolecular interactions, generating thousands of publications each year. An inconvenient effect that complicates interpretation of SPR results is the "bulk response" from molecules in solution, which generate signals without really binding to the surface. Here we present a physical model f