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Statistical Modelling of Cell Cycle Dynamics Analysis and Interpretation of BrdUrd DNA FCM-Derived Data

Popular Abstract in Swedish Cancer är en av de vanligaste dödsorsakerna i Sverige idag och att kunna ge cancerpatienter en bättre behandling är därför av stort intresse. En del av detta arbete består av att förbättra förståelsen för hur en cellpopulation, eller då speciellt en cancertumör, växer. Ett medel för att öka kunskapen på området är att använda matematiska modeller. Förmågan att kunna föIt it of great importance to increase the knowledge of various cell cycle kinetic parameters and the objective of this thesis is to use stochastic models to interpret Bromodeoxyuridine (BrdUrd) DNA Flow Cytometry (FCM) derived data in order to estimate such parameters. The cell cycle is the process of growth and division that is essential for an organism to increase in size. The cell cycle consist

Renal Transplant Patients at High Risk of Acute Rejection Benefit From Adequate Exposure to Mycophenolic Acid.

BACKGROUND.: To better define subpopulations in which achieving adequate mycophenolic acid (MPA) concentrations quickly would be important, a post hoc exploratory analysis on the fixed-dose concentration-controlled database was performed, comparing high- versus low-risk renal transplant patients. METHODS.: Renal transplant patients were treated with mycophenolate mofetil, corticosteroids, and cycl

Delineating the cellular pathways of hematopoietic lineage commitment.

The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compellin

Variation of breast cancer risk among BRCA1/2 carriers

CONTEXT: The risk of breast cancer in BRCA1 and BRCA2 mutation carriers has been examined in many studies, but relatively little attention has been paid to the degree to which the risk may vary among carriers. OBJECTIVES: To determine the extent to which risks for BRCA1 and BRCA2 carriers vary with respect to observable and unobservable characteristics. DESIGN, SETTING, AND PARTICIPANTS: Probands

On reduced-complexity equalization based on Ungerboeck and Forney observation models

This correspondence investigates the asymptotic behavior of reduced-state ISI equalizers, based on the Ungerboeck and Forney observation models. It is shown that Ungerboeck-based equalizers can suffer from correct-path-loss (CPL) even in the noiseless regime. ISI conditions that lead to CPL are analytically derived and illustrated by examples.

Den postpolitiska eran?

De senaste decenniernas samhällsvetenskapliga debatt har kretsat kring föreställningen att det skett ett epokgörande skifte. Industrisamhället har övergått i ett postindustriellt samhälle och moderniteten har ersatts av ett postmodernt tillstånd. Postmodernismen har ansetts markera ett slut för alla stora berättelser, ideologier och politiska projekt om emancipation. Denna era har på så sätt också

OVERVIEW, PRACTICAL TIPS AND POTENTIAL PITFALLS OF USING AUTOMATIC EXPOSURE CONTROL IN CT: SIEMENS CARE DOSE 4D.

Today, computed tomography (CT) systems routinely use automatic exposure control (AEC), which modulates the tube current. However, for optimal use, there are several aspects of an AEC system that need to be considered. The purpose of this study was to provide an overview of the Siemens CARE Dose 4D AEC system, discuss practical tips and demonstrate potential pitfalls. Two adult anthropomorphic pha

An endometrial stromal sarcoma cell line with the JAZF1/PHF1 chimera

Endometrial stromal sarcomas (ESS) are rare malignancies, accounting for less than 10% of uterine sarcomas. Apart from the chromosomal rearrangement t(7;17)(p15;q21), which leads to the JAZF1/SUZ12 chimera, cytogenetic studies have shown that the chromosome band 6p21 is often rearranged in ESS. The translocation partners involved in the 6p21 rearrangements differ among the tumors, but chromosome 7