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Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer's disease

INTRODUCTION: Matrix metalloproteinases (MMP) are believed to be involved in the pathologic processes behind Alzheimer's disease (AD). In this study, we aimed to examine the cerebrospinal fluid (CSF) levels of MMPs and tissue inhibitors of metalloproteinase-1 (TIMP-1) in individuals with AD dementia and cognitively healthy elderly individuals, and to investigate their relationship with established

A comprehensive approach to rehabilitation interventions following breast cancer treatment - a systematic review of systematic reviews

BACKGROUND: Breast cancer (BC) is the most common type of cancer in women worldwide. Post-treatment, patients suffer from side effects and have various rehabilitation needs, which means that individualization is fundamental for optimal rehabilitation. This systematic review (SR) of SRs aims to evaluate the current evidence on rehabilitation interventions in female patients following BC treatment.M

Solen och andra stjärnor

Vår sol är endast en av hundra miljardtals stjärnor i vår Galax. Den är en levande stjärna som ändras från dag till dag. Astronomer studerar solenss yta och dess inne med dedikerade solteleskop.Andra stjärnor därute sitter ofattbart långt från oss, men vi studerar dem ändå. I denna visning upptäcker vi hur stjärnhimlen ändras från en säsong till en annan och vi ser hur stjärnornas rörelse kan hjälOur sun is only one of hundreds of billions in our galaxy. It is a living star and it changes from one day to the next. Astronomers study the solar surface and its interior with dedicated solar telescopes.Other stars are more distant, but we study them also. In this planetarium show we discover how the night sky changes from one season to another and we see how the movement of the stars can lead u

Asteroider

Asteroiden 3122 Florence flög förbi Jorden i början av September 2017 och astronomer lyckades fånga bilder av asteroiden som visar att den har två månar kretsande runt om sig. I denna visning diskuterar vi vad vi vet om asteroiderna i vårt solsystem, hur stora de är, hur många och vad vi skulle kunna göra om en asteroid var på väg mot Jorden.The asteroid 3122 Florence flew past the Earth in early September 2017 and astronomers managed to capture images showing that it had two moons in orbit around it.In this planetarium show we discuss the asteroids in our Solar System, what we know about them, how large they are, how many there are and what we could do if we discovered one on a collision course with Earth.

The PDGF pathway in breast cancer is linked to tumour aggressiveness, triple-negative subtype and early recurrence

Purpose: The platelet-derived growth factor (PDGF) signalling pathway is often dysregulated in cancer and PDGF-receptor expression has been linked to unfavourable prognostic factors in breast cancer (e.g. ER negativity, high Ki67 and high grade). This study aimed to evaluate the expression of PDGFRα, PDGFRβ and ligand PDGF-CC in breast cancer in relation to molecular subtypes and prognosis. Method

Stjärnbilder och planeter

Vad kan du se när du tittar upp nattetid? Stjärnor, planeter, månen, kanske även stjärnfall? Känner du igen några stjärnbilder?I denna interaktiva planetariumföreställning bjuder vi våra yngsta besökare på en upptäcktsfärd bland natthimlens stjärnor innan vi lämnar Jorden och flyger ut i rymden för att tillsammans besöka solsystemets olika planeter.What can you see when you look up at night? Stars, planets, the Moon, maybe even a shooting star? Do you know any of the constellations?In this interactive planetarium show we invite your youngest visitors to explore the night sky and to fly out into the Solar System to visit the planets.

The development of obligatory liaison in early L2 learners of French

Studies on the acquisition of French liaison have primarily focused on monolingual children or adult second language (L2) learners in a university context. To bridge the gap between these two populations, the present article focuses on child L2 (cL2) learners – a particularly interesting group, since they are L2 learners who, unlike adults, do not have access to writing. How does liaison develop i

Socialtjänstens barnavårds­-utredningar i privat regi

Mycket forskning inom olika vetenskapsområden har länge haft fokus på social­tjänstens insatser för barn i olika avseenden och även på privatiseringen av verkstäligheten av vården. Det saknas däremot studier som fokuserar på förekomsten av privata konsulter som genomför barnavårdsutredningar. Det innebär också att det idag är oklart vilka konsekvenser en sådan förändring innebär för socialtjänsten

Perturbation order effect in multiphoton ionization of He+ ions

We study the behavior of the multiphoton ionization rate of He+ ions as a function of the perturbation order N. By comparing the N-, (N+1)-,..., (N+S)-photon ionization processes, we prove that the absorption of photon in the continuum spectrum is increased at the largest wavelengths.

High-order harmonic generation in rare gases with a 1-ps 1053-nm laser

We present experimental results of harmonic generation using a 1-ps 1015-W/cm2 Nd-glass laser. We see up to the 29th harmonic in Xe, 57th in Ar, and at least up to the 135th harmonic in Ne (160 eV), being then limited by our monochromator's resolution. The conversion efficiencies in Xe, Ar, Ne, and He are compared and different ways of optimizing the number of photons by defocusing the laser beam

Two-photon electron detachment of negative iodine

The authors have calculated two-photon electron detachment cross sections of the 5p shell of negative iodine in the photon energy region 0-1 Ryd. The results cover the region from the two-photon ionisation threshold of I - at 0.12 Ryd to well above the one-photon ionisation threshold of neutral iodine at about 0.8 Ryd. They demonstrate the importance of many-electron screening effects and double e

Many-body approach to two- and three-photon double ionization and excitation of xenon

We investigate different processes which may be responsible for ejection of two electrons from the external shell of xenon through the absorption of two and three photons, namely two-photon direct double ionization and three-photon sequential double ionization via the ion in an excited state or in the ground state. We calculate the cross sections of the ionization processes involved, using many-bo

Two-photon one-electron ionisation cross section of the 5p shell of xenon including screening effects

The authors present calculations of the two-photon one-electron ionisation of the 5p shell of xenon including non-linear response. Screening effects are described within the random-phase approximation (RPA). The authors use both a local-density approximation (LDA) and a Hartree-Fock average basis set. They describe a large energy region from the two-photon ionisation threshold to above the one-pho

High-order harmonic generation in strong laser fields

The recent advances concerning high-order harmonic generation processes in strong laser fields are discussed. We show how the width of the plateau inherent to the production of high harmonics varies with the pulse width, the laser wavelength and the atomic medium. Phase matching effects are discussed in terms of coherence length owing to the laser focusing. Finally, we show that the idea of genera

Linear and nonlinear screening effects in two-photon ionization of xenon

We apply the random-phase approximation to two-photon ionization. We develop a formalism which, by means of screened electron-photon interactions, includes the nonlinear response and, in particular, double-excitation processes. The theory is illustrated by numerical calculations of the two-photon ionization cross section of the external (5p and 5s) shell of xenon, over a large energy range: from t