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Accurate quantification of blood flow wall shear stress using simulation-based imaging : a synthetic, comparative study

Simulation-based imaging (SBI) is a blood flow imaging technique that optimally fits a computational fluid dynamics (CFD) simulation to low-resolution, noisy magnetic resonance (MR) flow data to produce a high-resolution velocity field. In this work, we study the effectivity of SBI in predicting wall shear stress (WSS) relative to standard magnetic resonance imaging (MRI) postprocessing techniques

KÁRMÁN VORTEX CITY OF DNA STRANDS

Kármán vortex streets are repeating patterns of swirling vortices, appearing when a fluid passes an obstacle at Re>50. We present an array of interacting vortices, a Kármán vortex city, that arises when a DNA solution flows through an array of micro posts at Re

Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia : Results from the HEAT-AML trial

Background: Treatment of newly diagnosed acute myeloid leukaemia (AML) is based on combination chemotherapy with cytarabine (ara-C) and anthracyclines. Five-year overall survival is below 30%, which has partly been attributed to cytarabine resistance. Preclinical data suggest that the addition of hydroxyurea potentiates cytarabine efficacy by increasing ara-C triphosphate (ara-CTP) levels through

Genotype-phenotype correlation in arrhythmogenic right ventricular cardiomyopathy-risk of arrhythmias and heart failure

BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is predominantly caused by desmosomal genetic variants, and clinical hallmarks include arrhythmias and systolic dysfunction. We aimed at studying the impact of the implicated gene(s) on the disease course. METHODS: The Nordic ARVC Registry holds data on a multinational cohort of ARVC families. The effects of genotype on electrocard

Cognitive behavioral treatment for disordered gaming and problem gambling in adolescents : a pilot feasibility study

Background: Disordered gaming and problem gambling (DG/PG) are associated with a range of functional impairments as well as psychiatric comorbidity. With the proliferation of digital gaming apps aimed at children and adolescents, which involve in-game purchases, there is increasing evidence that DG/PG are on the rise in this age range. The behavior can be detected in youth presenting at school-bas

Norm-critical innovation as a way forward for responsible innovation? Evidence from a Swedish innovation policy program

In 2014, the Swedish innovation agency Vinnova set up the program ‘Gender and Diversity for Innovation’, which has its roots in norm-critical innovation. In line with rationales for responsible innovation, a central aim of the program is to identify and challenge discriminatory norms to develop more inclusive and equal innovation processes. This article presents the findings of an in-depth analysi

South West and Central Asia

This chapter covers prosodic features of languages across Southwestern, Central, and Northern Asia. One representative language from each of the four main language families is passed in review, Turkish (Turkic), Mongolian (Mongolic), Persian (Indo-European), and Georgian (Kartvelian). Owing to a lack of descriptive coverage of the prosody of languages in Central Asia, no comprehensive surveys are

The association between serum estradiol levels and sperm DNA integrity

In men from the general population, BMI has been associated with a lower sperm DNA fragmentation index (DFI). We wondered whether this could be due to estradiol, which is associated with BMI and reported important for sperm function. Our objective was to investigate the association between estradiol and DFI. In 2008–2010, we recruited 284 young men from the general population to deliver samples of

eHealth literacy and socioeconomic and demographic characteristics of parents of children needing paediatric surgery in Sweden

Aim: The aim of the study was to describe different eHealth literacy domains among parents of children needing paediatric surgery in Sweden, and the correlation between these eHealth literacy domains and parents' socioeconomic factors and demographic characteristics. Design: Descriptive correlational design. Method: Thirty-five Swedish-speaking parents participated as a historical control group wi

Applying lessons from aviation safety culture in the hospitality industry : a review and road map

It is widely accepted that positive safety culture improves organizations’ safety performance and reduces the number of injuries and deaths. Safety culture has been well researched in high-risk industries; however, the hospitality industry until recently had no research of the concept unless related to food safety. This article explores theoretical grounds for research of safety culture in hospita

Structural basis of ion uptake in copper-transporting P1B-type ATPases

Copper is essential for living cells, yet toxic at elevated concentrations. Class 1B P-type (P1B-) ATPases are present in all kingdoms of life, facilitating cellular export of transition metals including copper. P-type ATPases follow an alternating access mechanism, with inward-facing E1 and outward-facing E2 conformations. Nevertheless, no structural information on E1 states is available for P1B-

Measuring Up to the Humanities : Navigating the Epistemological Advantage of Classical Humanism in Nineteenth-Century Scholarly Periodicals

This chapter analyzes the epistemological hierarchy around the middleof the nineteenth century in Sweden through efforts to mobilize supportfor natural science in scholarly periodicals. It is argued that scholarlycommunication was key to achieving legitimacy for natural science, butthat such efforts were mitigated by a dominant view of the humanitiesin general and classical humanism in particular