Journal of Thrombosis and Haemostasis Supplement 1(3): abstract 0204. DOI: 10.1111/j.1538-7836.2005.03001.x

Mitochondrial metabolism is a major determinant of insulin secretion from pancreatic β-cells. Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in response to glucose. This results in hyperglycemia and metabolic dysregulation. Evidence has recently been mounting that mitochondrial dysfunction plays an important role in these processes. Monogenic dysfunction of mit

J Thromb Haemostas 2009;7(Suppl2): abstract 721. DOI: 10.1111/j.1538-7836.2009.03473_2.x

Resected hippocampal tissue from patients with drug-resistant epilepsy presents a unique possibility to test novel treatment strategies directly in target tissue. The post-resection time for testing and analysis however is normally limited. Acute tissue slices allow for electrophysiological recordings typically up to 12 hours. To enable longer time to test novel treatment strategies such as, e.g.,

In this study, electrospinning has been employed to produce micro to nano scale fibres of whey protein in order to investigate their potential for use in the food industry. Initially, spinning of pure whey protein proved challenging; so in order to facilitate the spinning of freshly prepared aqueous solutions, small amounts of polyethylene oxide (as low as 1% w/w in solution) were incorporated in

This article takes stock of the world's largest low-carbon technology demonstration programme – the EU's NER 300. The programme has been marked by delays and many withdrawn projects since becoming operational in 2010: CCS projects have failed and not reached final investment decisions; wind and solar projects have succeeded, whereas bioenergy projects have seen successes as well as failures. These

In the article I investigate the differences between Ansel Adams' and Jerry Uelsmann's use of nature in their respective photography. Through their attitudes, approaches to, and involvement with nature their different relations to the photographic medium and the creative process unfold. Uelsmann's departure from the straight photographic tradition - that Ansel Adams came to symbolize - is in the a

To improve the identification and separation of leptons in the Hadron Calorimeter of DELPHI, one of the four LEP experiments at CERN, the possibility of a direct read-out of the cathodes of the 20,000 limited streamer tubes was studied and successfully tested on a small scale. A larger scale test started in June 1994. This new system which is independent of the present pad read-out provides a “yes

Ischemic stroke and traumatic brain injuries (TBI) are leading causes of disability and death worldwide. Both injuries result in regional cell death and disruption of local and remote functional neuronal networks, leading to loss of neurological function. Despite much effort spent on developing pharmacological therapies to reduce neuronal damage following these conditions, no neuroprotective strat

Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alon

Predictability of extreme changes in the Arctic Ocean freshwater content and the associated release into the subpolar North Atlantic up to one decade ahead is investigated using a CMIP5-type global climate model. The perfect-model setup consists of a 500 year control run, from which selected 10 year long segments are predicted by initialized, perturbed ensemble predictions. Initial conditions for

Background:In early breast cancer, five histopathological biomarkers are part of current clinical routines and used for determining prognosis and treatment: estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (ERBB2/HER2), Ki67, and Nottingham histological grade (NHG). We aimed to develop classifiers for these biomarkers based on tumor mRNA-sequencing (RNA

Background: Fear of falling is common among persons with Parkinson's disease and is negatively associated with quality of life. However a lack of in-depth understanding of fear of falling as a phenomenon persists. This qualitative study aimed to explore the experiences of fear of falling in persons with Parkinson's disease. Methods: Individual interviews were performed with twelve persons with Par

This article examines the links between post-conflict states’ troop contributions to international peacekeeping missions and security sector reform (SSR). It shows how SSR and troop-contribution preparations are increasingly interwoven and at times perceived as complementary by both external and internal actors. Some of the objectives sought after in SSR, such as the modernization of the military

We demonstrate the control of multiphoton electron excitations in InAs nanowires (NWs) by altering the crystal structure and the light polarization. Using few-cycle, near-infrared laser pulses from an optical parametric chirped-pulse amplification system, we induce multiphoton electron excitations in InAs nanowires with controlled wurtzite (WZ) and zincblende (ZB) segments. With a photoemission el

Objectives. Our aim was to describe the burden of early dcSSc in terms of disability, fatigue and pain in the European Scleroderma Observational Study cohort, and to explore associated clinical features. Methods. Patients completed questionnaires at study entry, 12 and 24 months, including the HAQ disability index (HAQ-DI), the Cochin Hand Function Scale (CHFS), the Functional Assessment of Chroni

Importance: Twin studies have assessed sibling resemblance for major depression (MD) but cannot address sources of resemblance across generations. Objective: To clarify the relative importance of genetic and rearing effects on the parent-offspring resemblance for MD. Design: This Swedish population register-based study examined parents and children from the following 5 family types: intact (2 041