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A Magnetic Resonance Imaging Study of Intestinal Dilation in Trypanosoma cruzi-infected Mice Deficient in Nitric Oxide Synthase
Infection with Trypanosoma cruzi causes megasyndromes of the gastrointestinal (GI) tract. We used magnetic resonance imaging (MRI) to monitor alterations in the GI tract of T. cruzi-infected mice, and to assess the role of nitric oxide (NO) in the development of intestinal dilation. Brazil strain-infected C57BL/6 wild-type (WT) mice exhibited dilatation of the intestines by 30 days post-infection.
Diblock polyampholytes grafted onto spherical particles: Effect of stiffness, charge density, and grafting density
The structure of spherical brushes formed by symmetric diblock polyampholytes end-grafted onto small spherical particles in aqueous solution is examined within the framework of the so-called primitive model using Monte Carlo simulations. The properties of the two blocks are identical except for the sign of their charges. Three different chain flexibilities corresponding to flexible, semiflexible,
Sensitivity of the woodland herb Anemone hepatica to changing environmental conditions
The decline of deciduous woodland populations of Anemone hepatica L. in southern Sweden is documented and possible causes are discussed. The study was based on (1) re-investigations of 6.25 km(2) grid-squares first studied in 19381970, (2) distribution of A. hepatica in woodland sites with well-known soil chemical properties and (3) a detailed study over 12 consecutive years into the relationships
Noninvasive acoustic cell trapping in a microfluidic perfusion system for online bioassays
Techniques for manipulating, separating, and trapping particles and cells are highly desired in today's bioanalytical and biomedical field. The microfluidic chip-based acoustic noncontact trapping method earlier developed within the group now provides a flexible platform for performing cell- and particle-based assays in continuous flow microsystems. An acoustic standing wave is generated in etched
Multicentre Phase II Trial of Paclitaxel and Carboplatin with Concurrent Radiotherapy in Locally Advanced Non-small Cell Lung Cancer
Aim: To evaluate weekly, induction chemotherapy followed by weekly concomitant chemoradiotherapy in a multicentre phase II study of patients with wiresectable stage III non-small cell lung cancer (NSCLC; stage wet IIIB excluded). Patients (aid Methods: Eligible patients received three weekly cycles of paclitaxel 100 mg/m(2) and carboplatin AUC2 followed by six weekly cycles of paclitaxel 60 mg/m(2
BRAIN INJURY ACTIVATES MICROGLIA THAT INDUCE NEURAL STEM CELL PROLIFERATION AND PROMOTE DIFFERENTIATION OF NEUROSPHERE-DERIVED CELLS INTO NEURONS AND TO OLIGODENDROCYTES
Mapping fractional forest cover across the highlands of mainland Southeast Asia using MODIS data and regression tree modelling
Data from the moderate-resolution imaging spectroradiometer (MODIS) sensor, in combination with new mapping techniques, has the potential to improve regional research on tropical forest resources and land use dynamics. In this study, a supervised regression tree model was used to map fractions of (1) mature forest, (2) secondary forest, and (3) non-forest, using multi-temporal MODIS 250-m data as
A unique recent origin of the allotetraploid species Arabidopsis suecica: Evidence from nuclear DNA markers
A coalescent-based method was used to investigate the origins of the allotetraploid Arabidopsis suecica, using 52 nuclear microsatellite loci typed in eight individuals of A. suecica and 14 individuals of its maternal parent Arabidopsis thaliana, and four short fragments of genomic DNA sequenced in a sample of four individuals of A. suecica and in both its parental species A. thaliana and Arabidop
Assessing the potential of wind power in Romania within Kyoto targets
The Kyoto target for Romania was to reduce its carbon dioxide emissions by 8 % from the 1989 levels. The 1989 emissions were around 260 million tones. In 2000 the net CO2 emission - some 125 million tones - were 54% of the net CO2 emission in the reference year -1989, leaving some 115 million tones as a reserve or as a tradable resource to other countries that can not met their Kyoto targets. Assu
Late DNA synthesis in heterochromatin.
Large vestibular evoked myogenic potentials in response to bone-conducted sounds in patients with superior canal dehiscence syndrome
Dehiscence of the superior semicircular canal is a 'new' vestibular entity. Among these patients, the vestibular evoked myogenic potentials (VEMP) in response to air-conducted sounds are large. In the present study, VEMP in response to bone-conducted sounds were studied in 5 normal subjects, in 3 patients after ( unilateral) labyrinthectomy and in 4 patients with ( unilateral) superior canal dehis
Prostaglandin E(2) and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: No impact on survival of seizure-generated neurons.
Partial and generalized status epilepticus (pSE and gSE) trigger the same level of progenitor cell proliferation in adult dentate gyrus, but survival of new neurons is poor after gSE. Here, we show markedly elevated levels of prostaglandin E-2 (PGE(2)) and brain-derived neurotrophic factor (BDNF) in rat hippocampal formation at 7 days following pSE but not gSE. Administration of the cyclooxygenase
Gas detection by correlation spectroscopy employing a multimode diode laser
A gas sensor based on the gas-correlation technique has been developed using a multimode diode laser (MDL) in a dual-beam detection scheme. Measurement of CO2 mixed with CO as an interfering gas is successfully demonstrated using a 1570 run tunable MDL. Despite overlapping absorption spectra and occasional mode hops, the interfering signals can be effectively excluded by a statistical procedure in
Ordovician limestone in Hälsingland, Sweden
Limestone boulders of Early and Middle Ordovician age occur along the Baltic coast of Sweden from c. 59 degrees N to c. 62.5 degrees N, apparently at a considerable distance from any known source rocks on land. We have investigated a limestone block from Lake Kultebo, at 61 degrees N, not far inland. The conodont elements enclosed in the rock are of Mid-Ordovician age and show that the block could
Neuropeptide Y inhibits in vitro epileptiform activity in the entorhinal cortex of mice.
Previous studies show that neuropeptide Y (NPY) inhibits in vitro seizures in rodent hippocampus. Here, we explored the effect of NPY application on epileptiform discharges induced by perfusion with magnesium-free solution in slices of entorhinal cortex from two different mouse strains. NPY significantly reduced the duration of epileptiform discharges with a peak effect of 36–50%. This is the firs
Locke and the Non-arbitrary
In this article, John Locke's accounts of political liberty and legitimate government are read as expressions of a normative demand for non-arbitrariness. I argue that Locke locates infringements of political liberty in dependence on the arbitrary will of another, whether or not interference or restraint actually takes place. This way Locke is tentatively placed in that tradition of republican tho
'Inadequate' dietary habits and mastication in elderly men.
Selective catalytic oxidation of ammonia to nitrogen at low temperature on Pt/CuO/Al2O3
Pt/CuO/Al2O3 catalysts with 20 wt% CuO and 0.5-4 wt% Pt were prepared and used for the selective catalytic oxidation of ammonia in wet and dry gases and in synthetic biogas with CO, hydrogen, and methane. Imaging of the catalysts with HREM and STEM, combined with elemental analysis, reveals that copper is well dispersed and Occurs in the form of patches on the support. Platinum in the form of nano
High Resolution X-Ray Photoelectron Spectroscopy and INDO/S-CI Study of the Core Electron Shakeup States of PMDA-ODA Polyimide
Pyromellitic dianhydride-4,4-oxydianiline (PMDA–ODA) polyimide films have been studied using high resolution x-ray photoelectron spectroscopy and model semi-empirical INDO/S–CI calculations. Experimental and theoretical C 1s, N 1s, and O 1s spectra are presented, and found to be in good agreement with each other. Shakeup features of the spectra are identified, and their electronic nature analyzed