Molecular-level computer simulations of peptide aggregation, translocation, and protonation at and in biomembranes are impeded by the large time and length scales involved. We present a computationally efficient, coarse-grained, and solvent-free model for the interaction between lipid bilayers and peptides. The model combines an accurate description of mechanical membrane properties with a new gra

Background: Many studies have investigated the prognostic role of biomarkers in colorectal liver metastases (CRLM). However, no biomarker has been established in routine clinical practice. The aim of this study was to scrutinize the current literature for biomarkers evaluated by immunohistochemistry as prognostic markers in patients with resected CRLM. Methods: A systematic review was performed ac

We present measurements of one-dimensional superconductor-semiconductor Coulomb islands, fabricated by gate confinement of a two-dimensional InAs heterostructure with an epitaxial Al layer. When tuned via electrostatic side gates to regimes without subgap states, Coulomb blockade reveals Cooper-pair mediated transport. When subgap states are present, Coulomb peak positions and heights oscillate in

Bidraget analyserar Kinas folkrättsliga strategi med avseende på att använda militärt våld i cyberrymden. Kinas statspraxis och opinio juris (d v s dess folkrättsliga övertygelse) undersöks och kinesiska folkrättsvetenskapliga yttranden oc ståndpunkter granskas.

Recension av Tim Marshall, Geografins makt: Tio kartor som förklarar världen, övers. Pär Svensson, Volante, Stockholm 2018 (343 s.) och Thomas Reinertsen Berg, Kartornas historia, övers. Jan Wibom, Lind & Co, Stockholm 2018 (351 s.).

I forskningsmiljön Children’s and Young People’s Health in Social Context,CYPHiSCO, förenar forskare vid Högskolan Kristianstad sitt intresse för barns, tonåringars och unga vuxnas psykiska och fysiska hälsa, välbefinnande och delaktighet. I CYPHiSCO bedrivs både grundforskning om faktorer som står i samband med hälsa och tillämpad forskning såsom aktionsforskning eller utvärderingar av prevention

Det estetiska området har visat sig viktigt för människors möjlighet att uttrycka sig och kommunicera med andra. Förmåga till socialt och kulturellt deltagande har stor betydelse för individens hälsa och välbefinnande. Intresset för att undersöka och utveckla estetiska aktiviteter för barn och unga med olika slag av funktionsnedsättning måste dock anses vara ganska begränsat, något som står i kont

Computers and digital instruments change the way we think about ourselves and other people, demonstrated by an example with a girl who imagined that she had a computer in her brain where she could click on “Music” in the menu to hear music. This chapter argues that good music technology should allow play and unpredictable events and support a balance between challenge and ability. Digital instrume

Some 4 billion years ago, nature began the experiment that led to you, that bird on the branch, that branch, and everything else which is alive that you see around you. The generating process of all this splendid life is, of course, evolution. Evolution works not only on the macroscopic scale (think eyes, muscles, wings) but also on the molecular scale (think molecular antennas, nanoscale muscles,The sequence diversity of protein families is a result of the biophysical selection pressures that shaped their evolutionary history. Among the dominant pressures is selection for protein thermostability, which in itself is an attractive target in protein engineering because of its importance for various biopharmaceutical properties, the performance of industrial enzymes, and the ability to design

A search for dark matter produced in association with a Higgs boson decaying to b-quarks is performed using pp collisions at a centre-of-mass energy of √s=13 TeV. The dataset has an integrated luminosity of 79.8 fb−1 and was recorded with the ATLAS detector at the Large Hadron Collider. Selected collision events comprise large missing transverse momentum and either two b-tagged small radius jets o

We analyze numerically the critical properties of a two-dimensional discretized random surface with extrinsic curvature embedded in a three-dimensional space. The use of the toroidal topology enables us to enforce the non-zero external extension without the necessity of defining a boundary and allows us to measure directly the string tension. We show that a most probably second- order phase transi

The finite temperature behaviour of lattice QCD with dynamical quarks for small number of flavours Nf is investigated. Simulations have been performed on lattices of size N3σ·4 with Nσ=8 and 12 and staggered fermions of mass ma=0.1 using a hybrid algorithm. We find that the two state signal at the critical point of the pure gauge theory, which is taken as sign for a fiorst order phase transition,

Cities are key actors in reducing both the causes of climate change (mitigation) and its impact (adaptation), and many have developed separate mitigation and adaptation strategies and measures. However, in order to maximize outcomes, both scholars and practitioners are increasingly calling for more integrated and synergetic approaches. Unfortunately, related research remains scarce and fragmented,