Primary HPV screening for cervical cancer by HPV mRNA testing (Aptima)was implemented in January 2017, for women ≥30 through 70 years, in the Region of Skåne, Sweden. HPV positive samples underwent cytology assessment, and women with any degree of abnormal cytology were referred for colposcopy. The aim was to audit the primary HPV screening program, by comparing the cytology results to those of co

The 129Sv mouse gene coding for the alpha1-microglobulin/bikunin precursor has been isolated and characterized. The 11kb long gene contains ten exons, including six 5'-exons coding for alpha1-microglobulin and four 3'-exons encoding bikunin. Exon 7 also codes for the tribasic tetrapeptide RARR which connects the alpha1-microglobulin and bikunin parts. The sixth intron, which separates the alpha1-m

M proteins and M-like proteins, expressed on the surface of group A streptococci and binding to human plasma proteins, can be divided into two classes, A and C, depending on the structure of the central repeated regions. The class C proteins have been shown to be dimers with a coiled-coil structure. In this work, we have compared the structure and binding of a class A protein, Mrp4, and a class C

We obtained 10/192 and 3/384 antibody-secreting hybrids after immunization of Balb/c mice with either human growth hormone or affinity-purified rabbit anti-(human growth hormone) respectively. Radiolabelled rabbit anti-(human growth hormone) antibodies, but not human growth hormone, were specifically bound by supernatants from the 13 hybrids. The binding was completely inhibited by human-growth-ho

American Foulbrood (AFB) is a particularly pernicious bacterial disease of honey bees due to the extreme persistence of endospores of the causative agent Paenibacillus larvae. These spores are resistant to harsh environmental conditions, unaffected by antimicrobial agents and can remain viable for decades. The germination of the endospore in the larval midgut is the crucial first step leading to i

Deepened knowledge on response of biota and ecological processes following fire is essential for a future with warmer climate and more disturbances. In 2014 the first mega-fire (13,100 ha) for at least a century in Scandinavia hit south-central Sweden, in a production forest landscape shaped by clearcutting forestry. Ecological dynamics is followed in >20 projects from universities, authorities an

Epigenetic mechanisms control gene activity and the development of an organism. The epigenome includes DNA methylation, histone modifications, and RNA-mediated processes, and disruption of this balance may cause several pathologies and contribute to obesity and type 2 diabetes (T2D). This Review summarizes epigenetic signatures obtained from human tissues of relevance for metabolism—i.e., adipose

Core needle biopsies for lymphoma diagnosis seriously affect diagnostics, treatment development and research Core needle biopsies (CNBs) are widely used in clinical diagnostic labs to aid in the diagnosis of malignant lymphomas and in latter years their use is increasing. CNBs provide a rapid method for obtaining tumour material and may be beneficial when the affected lymph nodes are located deep

INTRODUCTION: Resent research has revealed an increased concentration of free fetal hemoglobin (HbF) in maternal serum from patients who subsequently develops preeclampsia (PE). In a previous study of 96 patients we have shown that HbF in combination with the heme-scavenger alpha-1-microglobulin (A1M) are potential predictive biomarkers of PE.OBJECTIVES: In this validating case-control study we ai

Background We have designed one-tube 14-antibody 10-color flow cytometry (FCM) panel that would provide maximum information on lymphoid and myeloid cell subsets in bone marrow aspirates (BMA) from patients with cytopenia(s). Samples and Methods BMA from 8 normal donors, from 286 non-malignant hospital controls, 92 myelodysplastic syndromes (MDS), 47 myeloproliferative neoplasms (MPN), and from 14

Enfaldig förklaring öfwer Lutheri lilla catechismum, stält genom spörsmåhl och swar / aff Olao Swebilio.Utgåva av Sveriges första riksnormerande katekes (1689) med inledning och noter.

We present a simple microfluidic-based synthesis protocol to fabricate snowman like Janus hydrogel particles of poly(N-isopropylacrylamide) (PNIPAM) in micron length scale. Particles are synthesized by emulsifying a hydrogel solution (water (w)/oil (o)) followed by partial solvent evaporation. Solvent evaporation allows the hydrogels to concentrate within the droplet and phase separate into a mono

The purpose of this research is to study the impact of temperature, precipitation, and wind speed on in situ concrete wall operations, and its combined resulting effect on project duration. The research presented is anchored in the learnings gained through a literature review on weather effects on construction operations, an analysis of weather data with high resolution, and two field studies of i

The pulp and paper industry is one of the most important industrial sectors worldwide. The focus of current pulp mills is on the production of cellulose pulp fibres and electricity. By converting traditional pulp mills into lignocellulosic biorefineries they can become a keystone in a future bioeconomy. In order to achieve this, pulp mills have to close their loops and focus on the optimal utilisa

We present a case of a patient in a severe pulmonary mucormycosis during the neutropenic phase of treatment for acute myeloblastic leukaemia (AML), type M2. He had two major risk factors for setting infection; leukaemia and diabetes mellitus. Although he received antimicrobial and antifungal therapy with Amphotericin B in time, it was unable to eradicate infection. We performed a pneumectomy, whic