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Detection of HPV mRNA in Self-collected Vaginal Samples Among Women at 69-70 Years of Age

BACKGROUND/AIM: Cervical cancer is associated with poorer diagnosis among the elderly and pap-smear screening has a lower sensitivity. Self-sampling for detection of high-risk human papillomavirus (hr-HPV) may be an alternative screening method. The aim of this study was to analyze the response rate to vaginal HPV self-sampling and the HPV mRNA prevalence among women 69-70 years. MATERIALS AND MET

Continuous drug delivery aiming continuous dopaminergic stimulation in Parkinson's disease

Continuous dopaminergic stimulation in Parkinson's disease (PD) has several advantages over pulsatile, noncontinuous, stimulation. These therapies currently consist of pump-based and transcutaneous therapies and are based on a more constant delivery of the dopaminergic drug resulting in continuous dopaminergic stimulation and a more stable treatment effect. Several clinical and experimental observ

Depositional history and provenance of cratonic “Purana” basins in southern India : A multipronged geochronology approach to the Proterozoic Kaladgi and Bhima basins

Peninsular India is a collage of Archaean cratonic domains separated by Proterozoic mobile belts. A number of cratonic basins, known as “Purana basins” in the Indian literature, formed in different parts of the Indian Peninsula during extensional tectonic events, from Paleoproterozoic through Neoproterozoic times. In this contribution, we present a diversity of new geochronological data for differ

Measurements and simulation of temperature in a portal frame bridge

Since thermal loads can cause cracking, they are important to consider in bridge design. In order to evaluate and develop thermal load cases based on real simulations, models for simulating temperatures can be used. In this paper, a model for thermal simulation is used to simulate temperature in a portal frame bridge outside Lund, Sweden. The results are compared with temperature measurements in 1

Homology and linkage in crossover for linear genomes of variable length

The use of variable-length genomes in evolutionary computation has applications in optimisation when the size of the search space is unknown, and provides a unique environment to study the evolutionary dynamics of genome structure. Here, we revisit crossover for linear genomes of variable length, identifying two crucial attributes of successful recombination algorithms: the ability to retain homol

Impact of Spatial Consistency on Dynamic Beamforming for Millimeter-Wave Cellular Systems

Millimeter-wave (mmWave) frequencies are set to play an important role in fifth-generation (5G) wireless systems. A pre-requisite for the design and performance assessment of 5G wireless is the understanding of the involved propagation processes and derivation of insightful channel models. Unlike bands below 6 GHz, several additional modelling features need to be catered for at mmWaves. For dynami

Low predictive power of comorbidity indices identified for mortality after acute arthroplasty surgery undertaken for femoral neck fracture

Aims Our aim was to examine the Elixhauser and Charlson comorbidity indices, based on administrative data available before surgery, and to establish their predictive value for mortality for patients who underwent hip arthroplasty in the management of a femoral neck fracture. Patients and Methods We analyzed data from 42 354 patients from the Swedish Hip Arthroplasty Register between 2005 and 2012.

Mathematics, measurement and experience of rotations around three axes

An amusement ride involving rotations around three axes offers a large-scale illustration for the study of dynamics in three dimensions. The forces on the rider can be measured with co-moving accelerometers. As a first approximation, the different motions can be treated separately, but the combination of rotations is found to lead to a relatively large Coriolis effect. A mathematical description o

Glucagon and insulin secretion, insulin clearance, and fasting glucose in GIP receptor and GLP-1 receptor knockout mice

It is not known whether GIP receptor and GLP-1 receptor knockout (KO) mice have perturbations in glucagon secretion or insulin clearance, and studies on impact on fasting glycemia have previously been inconsistent in these mice. We therefore studied glucagon secretion after oral whey protein (60 mg) and intravenous arginine (6.25 mg), insulin clearance after intravenous glucose (0.35 g/kg) and fas

The P1 histo-blood group antigen is present on human red blood cell glycoproteins

BACKGROUND: The P1 antigen was first described in 1927 and belongs to the P1PK histo-blood group system, together with Pk and NOR. The A4GALT-encoded 4-α-galactosyltransferase synthesizes these antigens and has been considered to extend glycolipids exclusively. However, contradicting studies have been published regarding the presence of P1 on human glycoproteins. In other species, P1 occurs on gly

Characteristic mode analysis of planar dipole antennas

Planar monopole antennas are popular due to their attractive properties, but their operating mechanisms are still not well understood. Based on image theory, planar monopoles can be analyzed using their dipole counterparts. Here, the bandwidth and radiation pattern of planar dipoles is studied in detail using characteristic mode analysis for different design parameters. The results show that insig

Does software optimization influence the radiologists' perception in low dose paediatric pelvic examinations?

Purpose: To investigate whether software optimisation can improve an observers’ perception of image quality in low dose paediatric pelvic examinations. Methods: Twenty-five consecutive patients (3–7 years old) were referred for a pelvic digital radiography (DR) examination. They were prospectively enrolled in the study over a 3-month period. Images were taken at 80 kV and 2–4 mAs depending on pelv

Impact of pH modification on protein polymerization and structure–function relationships in potato protein and wheat gluten composites

Wheat gluten (WG) and potato protein (PP) were modified to a basic pH by NaOH to impact macromolecular and structural properties. Films were processed by compression molding (at 130 and 150°C) of WG, PP, their chemically modified versions (MWG, MPP) and of their blends in different ratios to study the impact of chemical modification on structure, processing and tensile properties. The modification

Renal relapse in antineutrophil cytoplasmic autoantibody-associated vasculitis : unpredictable, but predictive of renal outcome

Objectives: To determine predictors of renal relapse and end-stage renal failure (ESRF) in patients with ANCA-associated vasculitis. Methods: Data from four European Vasculitis Society randomized controlled trials, conducted roughly simultaneously between 15 March 1995 and 30 September 2002, was pooled to determine predictors of long-term renal outcome. The respective trial inclusion criteria cove

Urban planning and town foundations

Urban growth is crucial for modernisation, and the wave of new towns in China since the 1980s is one example of a strategy employed by policymakers to encourage the process. This column analyses the long-run success of a town foundation policy in Sweden between 1570 and 1810. While the ‘artificially’ created towns failed to grow in the short term, they eventually began to grow and thrive, and toda

Continuous Positive Airway Pressure Treatment and Depression in Adults with Coronary Artery Disease and Nonsleepy Obstructive Sleep Apnea. A Secondary Analysis of the RICCADSA Trial

RATIONALE: Obstructive sleep apnea (OSA) and depression are common among adults with coronary artery disease (CAD). OBJECTIVES: To determine the impact of continuous positive airway pressure (CPAP) treatment on depression in adults with CAD and nonsleepy OSA. METHODS: This was a secondary analysis of the RICCADSA (Randomized Intervention with CPAP in CAD and Sleep Apnea) trial, conducted in Sweden

Break-up related 2170–2120 Ma mafic dykes across the North Atlantic craton : Final dismembering of a North Atlantic-Dharwar craton connection?

Progress with supercontinental reconstructions relies on accurate age determinations for continental geological units such as mafic dyke swarms. Here we present zircon and baddeleyite U-Pb ID-TIMS isotope data of six mafic dykes from the Archean North Atlantic craton in present-day southern West and South-East Greenland. Two dykes in southern West Greenland yield crystallization ages of 2021 ± 4 M

Neurologic disorders in 4858 survivors of central nervous system tumors in childhood-an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study

Background: A comprehensive overview of neurologic complications among survivors of central nervous system (CNS) tumors in childhood is lacking. We aimed to investigate the risk for these disorders in a large, population-based study with outcome measures from nationwide hospital registries. Methods: We identified 4858 five-year survivors with diagnoses of CNS tumor in childhood in Denmark, Iceland