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Single-cell transcriptional and functional analysis of dopaminergic neurons in organoid-like cultures derived from human fetal midbrain

Significant efforts are ongoing to develop refined differentiation protocols to generate midbrain dopamine (DA) neurons from pluripotent stem cells (PSCs) for application in disease modeling, diagnostics, drug screening, and cell-based therapies for Parkinson's Disease (PD). An increased understanding of the timing and molecular mechanisms promoting the generation of distinct subtypes of human mid

Status Quo Bias and Hidden Condorcet Cycles in Binary Referendums

In most real-life binary referendums, there are several alternatives that potentially can challenge the status quo alternative. Depending on which alternative that is selected, the voters are also differently likely to caste their vote on it. The fact that there are several potential challenger alternatives also means that there may exist Condorcet cycles that only can be identified by taking into

Experimental investigation of structural failure during the cooling phase of a fire : Concrete columns

Structures may collapse during the cooling phase of a fire, yet standard furnace tests only measure the response under heating. There lacks experimental test protocols and design methods to assess resistance until burnout. This paper describes a new experimental approach for burnout resistance evaluation, reports experimental data on loaded reinforced concrete columns in furnace tests with cooling