The purpose of this thesis has been to study biological and social factors of importance for Attention Deficit Hyperactivity Disorder (ADHD). Thirty children (age 6-11) with ADHD were examined with parent ratings, neurological examination, cognitive testing, cerebral blood-flow, and EEG. These children together with 14 other children the same age with ADHD, were video-taped during family-tasks be

Background and Objectives. The pathogenesis of otitis media (OM) involves a number of factors related to the anatomy, pathology, and cell biology of the middle ear, the mastoid, the Eustachian tube, and the nasopharynx. Although some issues of pathogenesis are fairly well established, others are only marginally indicated by current knowledge, and yet others remain undisclosed. The objective of thi

In the field of infectious diseases the multifaceted amino acid arginine has reached special attention as substrate for the hosts production of the antimicrobial agent nitric oxide (NO). A variety of infectious organisms interfere with this part of the host immune response by reducing the availability of arginine. This prompted us to further investigate additional roles of arginine during pathogen

Common genetic variants have been recently associated with fasting glucose and insulin levels in white populations. Whether these associations replicate in pre-diabetes is not known. We extended these findings to the Diabetes Prevention Program, a clinical trial in which participants at high risk for diabetes were randomized to placebo, lifestyle modification or metformin for diabetes prevention.

One of the big obstacles for understanding the nervous system is its inherent complexity. It poses problems when interpreting both experimental and theoretical studies since we are currently forced to consider only reduced variants of the actual circuitry of the brain. Since there exist problems that do not appear until a system is sufficiently complex, there are no guarantees that the results ste

When pathogenic bacteria breach the epithelial lining at mucosal surfaces, rapidly available innate immune mechanisms are critical to halt the infection. In the present study, we characterized the production of antibacterial polypeptides released by epithelial cells. IFN-γ, but neither TNF nor IL-1β alone, induced release of antibacterial activity to a cell culture medium, causing a lytic appearan

Background. Fast and accurate work-up is crucial to ensure the best possible treatment and prognosis for patients with head and neck cancer. The presence or absence of neck lymph node metastases is important for the prognosis and the choice of treatment. Clinical lymph node (N)-staging is done by palpation and diagnostic imaging of the neck. We investigated the current practice of the initial radi

A new approach for the classification of patients with Sjogren's syndrome (SS) has been recently proposed. Although these new criteria substantially differ from the American European Consensus Group criteria, which have represented the gold standard for the last decade, when compared with each other the two sets show a high statistical degree of agreement. However, the fact that two different crit

The impact of coherence on the nonlinear optical response and stationary transport is studied in quantum cascade laser structures. Nonequilibrium effects such as the pump-probe signals, the spatiotemporally resolved electron density evolution, and the subband population dynamics (Rabi flopping) as well as the stationary current characteristics are investigated within a microscopic density-matrix a

Although Disordered Eating Behaviors (DEB) is an ill-defined concept, multiple studies have examined prevalence of DEB and its relations to other variables in various populations. DEB have been shown to predict more serious eating disorders which in turn can lead to death. Mostly girls seem to suffer from DEB, but the question has been raised whether this, at least, partially is due to the methods

Abstract in UndeterminedEnterprise resource planning (ERP) systems are rapidly becoming a de facto standard in business activity. While large and medium-sized companies have the luxury to afford proprietary ERP solutions, small companies are struggling with resource poverty which maybe makes them consider available open source ERP products which are free from licensing fee. However, there is littl

Context-aware applications generally need to retrieve various kinds of dynamic context data from a large number of context sources. A middleware managing context sources must provide an efficient context lookup mechanism to ease application development. In this paper, we categorize the context sources as operating spaces and propose semantic peer-to-peer overlays over these spaces to accelerate dy

This article highlights our recent achievements on the development and upgrade of new potential tumor-specific contrast agents for magnetic resonance imaging (MRI) based on gadolinium complexes and peptides, assemblied in amphiphilic supramolecular aggregates. The physico-chemical characterization of these aggregates provides novel and interesting opportunities to investigate surfactant aggregatio

In patients with atrial fibrillation (AF), the fibrillatory frequency trend and the time-dependent spectral characteristics can be investigated using a spectral profile technique. The spectral profile is updated by fitting each short-time spectrum. The aim of this study is to develop model-based means for stricter control on the update of the spectral profile. A spectral model defined by a superpo

All municipalities in Sweden offer their inhabitants a service for disposing of large-size and hazardous waste at local recycling centres. Opening hours at these centres include hours of darkness. The aims of this study were to 1) describe user and employee experiences of lighting and signs at Swedish recycling centres, 2) measure and assess the lighting system at the two recently built recycling

Clopidogrel response varies according to the presence of genetic polymorphisms. The CYP2C19*2 allele has been associated with impaired response; conflicting results have been reported for CYP2C19*17, ABCB1, and PON1 genotypes. We assessed the impact of CYP2C19, PON1, and ABCB1 polymorphisms on clopidogrel and prasugrel pharmacodynamic (PD) and pharmacokinetic (PK) parameters. Aspirin-treated patie

Conifer feeding bark beetles (Coleoptera, Curculionidae, Scolytinae) pose a serious economic threat to forest production. Volatiles released by non-host angiosperm plants (so called non-host volatiles, NHV) have been shown to reduce the risk of attack by many bark beetle species, including the European spruce bark beetle, Ips typographus. However, the most active blend for I. typographus, containi

Context: Intermittent androgen deprivation (IAD) in prostate cancer (PCa) patients has been proposed to delay development of castration resistance and to reduce the side effects and costs of androgen deprivation therapy (ADT). Objective: This review analyzes (1) the oncologic and quality of life (QoL) results from randomized phase 3 trials comparing IAD and continuous ADT and (2) the prognostic pa