Hemophilia has evolved from an often fatal hereditary bleeding disorder to a disorder for which safe and effective treatment is available. However, there are several challenges remaining in the treatment of hemophilia. Prophylaxis to prevent bleeding is costly and requires frequent intravenous injections, which are cumbersome for patients. Venous access is often difficult to achieve, especially in

A comprehensive study was conducted to monitor the emission potential from solid waste landfilled in Jordan over a period of 292 days using an anaerobic lysimeter. A 30 kg waste sample reflecting the typical municipal solid waste (MSW) streams generated in Jordan was used to simulate the influence of climate on the emission potential of landfills located in semi-arid areas. The experimental result

Objectives. Hypothermia protects the myocardium from oxidative injury during ischemic stress and reperfusion. We have previously shown that topical negative pressure (TNP) of -50 mmHg significantly increases microvascular blood flow in the underlying myocardium in normal, ischemic, and reperfused porcine myocardium. The present study was designed to elucidate the effect of TNP between -50 mmHg and

n a previous paper (see abstr. A76748 of 1974) the expansion of the irreducible self-energy of an electron gas was studied and found to give unreliable results for the satellites of the one-electron spectra function. This was due to the incorrect analytic properties of the corresponding green function. These results are confirmed and extended by studying a simple model (s-model) which allows the n

Osteoporosis is a common complex disorder in postmenopausal women leading to changes in the micro-architecture of bone and increased risk of fracture. Members of the low-density lipoprotein receptor-related protein (LRP) gene family regulates the development and physiology of bone through the Wnt/β-catenin (Wnt) pathway that in turn cross-talks with the bone morphogenetic protein (BMP) pathway. In

Inflammation and ischemia have a synergistic damaging effect in the immature brain. The role of tumor necrosis factor (TNF) receptors 1 and 2 in lipopolysaccharide (LPS)-induced sensitization and tolerance to oxygen-glucose deprivation (OGD) was evaluated in neonatal murine hippocampal organotypic slices. Hippocampal slices from balb/c, C57BL/6 TNFR1(-/-), TNFR2(-/-), and wild-type (WT) mice obtai

The report focuses on an evacuation experiment, which was performed within the second work package of the Swedish METRO project. The experiment involved 100 participants, both men and women in the ages 18-66 years, who individually evacuated a smoke-filled rail tunnel of approximately 200 metres length. The main purpose of the experiment was to collect and derive data on human behaviour and moveme