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Human calcitonin (hCT) is a peptide hormone with therapeutic potential for bone-related disorders, yet its clinical application is hindered by a strong propensity to form amyloid fibrils. Strategies that effectively suppress hCT aggregation are therefore essential for enabling its reintroduction into pharmaceutical development. In our previous work, heme emerged as a potent inhibitor of hCT fibril
We present the structural and functional characterization of a single-stranded DNA-binding protein (SSB-M5) identified from a hot spring metagenome in Vatnajökull National Park, Iceland. This small protein (136 aa; 15,695 Da) shares 100% amino acid sequence identity with two previously uncharacterized SSBs from hyperthermophilic Fervidobacterium species. Functional complementation assay demonstrat
Interactions between amyloidogenic proteins are emerging as critical drivers of neurodegenerative diseases. Among others, in Alzheimer’s disease (AD) and severe forms of chronic traumatic encephalopathy (CTE), codeposition of tau and amyloid-β (Aβ) leads to worsening of clinical outcomes and disease progression. Despite the importance of such heterotypic interactions, the underlying molecular mech
BACKGROUND: Long COVID has emerged as a global health challenge, with increasing evidence of cardiovascular sequelae. Most previous studies have focused on hospitalised cohorts, whereas cardiovascular risk in community-managed long COVID cases remains less explored. We aimed to investigate the incidence of major cardiovascular events in individuals with long COVID compared to those without long CO
Postural orthostatic tachycardia syndrome (POTS) is associated with multiple autonomic symptoms, including gastrointestinal (GI) complaints, and has been linked to insulin resistance. We aimed to explore HbA1c, circulating metabolic hormones (insulin, C-peptide, GIP, GLP-1, glucagon, leptin, and peptide YY) and cortisol, and their associations with hemodynamic parameters and GI symptoms in POTS. T
This short documentary film narrates the socio-environmental conflict triggered by a large-scale copper mining project aimed at extracting critical minerals for the global Energy Transition from the heart of the Andean Amazon. Through Theatre of the Oppressed and the voice of Soraida Chindoy Buesaquillo, indigenous territorial defender, the film narrates the process of the Tent of Resistance in P
This article explores the potential of full-count historical census microdata to enhance our understanding of occupational activity and retirement among older men and women in Sweden between 1880 and 1910 – a period preceding the introduction of a universal pension system. Drawing on the SwedPop infrastructure, we examine how occupational information was recorded, coded, and interpreted in the Swe
BACKGROUND: The aim was to improve the realism of patient models for Monte-Carlo based evaluation of image-based quantification of tumour volume and activity in [68Ga]Ga-DOTA-TOC PET and [177Lu]Lu-DOTA-TATE SPECT images.METHODS: Three phantoms from the XCAT population were used as basis. Tumour structures were obtained from segmentation of patient 68Ga-PET images and positioned at relevant positio
The article examines Starbucks as a global cultural symbol whose success varies sharply across contexts, contrasting its exceptional growth in South Korea with its near failure in Sweden. In Korea, Starbucks has thrived by pioneering localized marketing and spatial design strategies, enjoying unusual autonomy from headquarters and shaping new consumption patterns; however, recent controversies hav
Short overview over possibilities top use archives of artistich research within film studies, in ordert to study uncompleted works
The collagen triple helix assembles hierarchically into bundled oligomers, solvated networks, and fibers. Synthetic peptide assemblies, driven by supramolecular interactions, can form single triple helices through intrahelical amino acid pairs; however, the principles guiding interhelical associations into higher-order structures remain unclear. Here, we incorporate cation−π and electrostatic char
In the fast-evolving arena of climate finance, equitable access to and allocation of funds for adaptation continue to pose a significant and urgent challenge. In theory, to prepare for the impacts of climate change in an equitable way, regional, national, and European Union (EU) funding tenders on climate adaptation should prioritize the most climate-vulnerable local administrations. However, evid
Packaging-free grocery shopping enables consumers to avoid single-use packaging and buy specific quantities tailored to their needs. Despite its benefits, it faces challenges such as limited product variety and availability. This qualitative study explores the motivations, behaviors, and strategies of individuals who engage in or discontinue packaging-free shopping, including how they combine pack
Rapid urbanization in Guangdong Province has severely impacted river systems due to limited understanding of the sustainability of river connectivity and functions. This study applies the Minimum Cumulative Resistance Model (MCRM) to quantify expansion costs of natural and social processes, with their difference defined as the River Ecological Sensitivity (RES) index. Higher RES values indicate th
Background: Access to safe and timely blood transfusion is a cornerstone of modern healthcare but depends on a stable supply of voluntary donations and rigorous hemovigilance systems. O-negative red blood cells are universally compatible and essential for emergency transfusions; however, their scarcity, particularly in low-resource regions, poses significant challenges. To address this challenge,
