I NJA 2016 s. 3 tillämpade Högsta domstolen mordbestämmelsen i dess nya lydelse. Högsta domstolen fann att det syfte som hade angetts i förarbetena — att skärpa straffen för mord — inte kom till uttryck i lagtexten. Högsta domstolen fortsatte därför att tillämpa det tidigare rättsläget enligt NJA 2013 s. 376. Avgörandet väcker frågor om metoden för prejudikattolkning och lagtolkning i svensk rätt,

Svensk Juristtidning har kommit ut i 100 år. Den svenska rättsordningen har under detta sekel genomgått genomgripande förändringar, men tydliga rättsliga grundstrukturer har bevarats. I denna uppsats görs ett försök att fånga vissa framträdande drag i juristtidningens innehåll och hur juristtidningen har förändrats, när det gäller både dess utformning och dess innehåll. Viktiga delar av innehållet

Om och i så fall på vilket sätt domarna är konstitutionella aktörer har varit föremål för omfattande debatter. Debatten rörande huruvida domarna kunde utöva konstitutionell kontroll över lagstiftningen övergick på 1960-talet till en debatt om närmare bestämt hur domarna skulle utöva denna kontroll. Det är en debatt som inte är avslutad; diskussionen om hur domarna ska hantera olika typer av konsti

Background:rhIGF-1/rhIGFBP-3 is being investigated for prevention of retinopathy of prematurity in extremely preterm infants.Methods:A population pharmacokinetic model was developed using data from phase I/II (Sections A-C) trials of rhIGF-1/rhIGFBP-3 and additional studies in preterm infants to predict optimal dosing to establish/maintain serum IGF-1 within physiological intrauterine levels. In S

P-wave morphology correlates with the risk for a trial fibrillation (AF). Left atrial (LA) enlargement could explain both the higher risk for AF and higher P-wave terminal force (PTF) in ECG lead V1. However, PTF-V1 has been shown to correlate poorly with LA size. We hypothesize that LA hypertrophy, i.e. a thickening of the myocardial wall, also contributes to increased PTF-V1 and is part of the r

Background: Coronary artery remodelling and vasospasm is a complication of acute myocardial ischemia and reperfusion. The underlying mechanisms are complex, but the vasoconstrictor peptide endothelin-1 is suggested to have an important role. This study aimed to determine whether the expression of endothelin-1 and its receptors are regulated in the myocardium and in coronary arteries after experime

Levodopa treatment is the major pharmacotherapy for Parkinson's disease. However, almost all patients receiving levodopa eventually develop debilitating involuntary movements (dyskinesia). Although it is known that striatal spiny projection neurons (SPNs) are involved in the genesis of this movement disorder, the molecular basis of dyskinesia is not understood. In this study, we identify distinct

L -DOPA-induced dyskinesia (LID) represents one of the major limitations in the current pharmacotherapy of Parkinson's disease (PD) and affects the majority of PD patients. Animal models are the most important preclinical tool for molecular investigations of LID mechanisms and therapeutic targets. Over the last two decades, models of LID have been developed in both nonhuman primate and rodent spec

L-DOPA-induced dyskinesia (LID) is a major complication of the pharmacotherapy of Parkinson's disease (PD). Animal models of LID are essential for investigating pathogenic pathways and therapeutic targets. While non-human primates have been the preferred species for pathophysiological studies, mouse models of LID have been recently produced and characterized to facilitate molecular investigations.

Bacterial drug resistance is a serious concern for human health. Multidrug efflux pumps export a broad variety of substrates out of the cell and thereby convey resistance to the host. In Escherichia coli, the AcrB:AcrA:TolC efflux complex forms a principal transporter for which structures of the individual component proteins have been determined in isolation. Here, we present the X-ray structure o

BACKGROUND AND OBJECTIVES: ABO-incompatible haematopoietic stem cell transplantation (HSCT) presents a challenge to blood component transfusion. The aim of this study was to investigate the weak blood group A or B antigen expression by donor-derived group O red blood cells (RBC) observed following transfusion or minor ABO-incompatible HSCT. In addition, in vitro experiments were performed to eluci

Treatment resistant depression (TRD) and suicidal behavior are among the most important public health problems and are commonly associated with significant disability and psychosocial impairment. Although there have been recent advances in identifying neurobiological correlates of these complex conditions, their pathophysiology still remains unclear. Although the recent advances concerning the neu

A novel multi-jet burner was built to provide one-dimensional laminar flat flames with a wide range of variable parameters for multipurpose quantitative optical measurements. The burner is characterized by two independent plenum chambers, one supporting a matrix of 181 laminar jet flames and the other supporting a co-flow from a perforated plate with small holes evenly distributed among the jets.

Fractures of the proximal part of the femur, hip fractures, are common and costly. The number of hip fractures has increased in all western countries during recent decades. This has occurred mainly because of an increase in the number of elderly people and also due to an increase in the risk for hip fracture among the oldest persons. Due to an increase in ageing population all over the world there

Background: Dietary risks today constitute the largest proportion of disability-adjusted life years (DALYs) globally and in Sweden. An increasing number of people today consume highly processed foods high in saturated fat, refined sugar and salt and low in dietary fiber, vitamins and minerals. It is important that dietary trends over time are monitored to predict changes in disease risk. Methods:

Experiments applying saturated laser-induced fluorescence (LSF) technology were performed focusing on the influence of equivalence ratio, syngas mixture contents, on NO formation in H2/CO/CH4/CO2/N2/O2 premixed flat flames supplied by a heat flux burner. Experimental data were extracted to validate calculation by CHEMKIN software. Both experiments and CHEMKIN calculation draw one conclusion that N