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Islet cell surface antibodies and lymphocyte antibodies in the spontaneously diabetic BB Wistar rat

Plasma from 14 diabetic and 6 nondiabetic BB Wistar rats along with plasma from 6 non-BB Wistar rats was evaluated for the presence of islet cells surface antibodies (ICSA) and antibodies to spleen lymphocytes by the protein-A radioligand assay. Dispersed Wistar rat islet cells incubated with plasma from diabetic rats bound 4255 +/- 2208 cpm 125I-protein A/5 x 10(4) islet cells (mean +/- SD) compa

Philosophy of science for sustainability science

Sustainability science seeks to extend scientific investigation into domains characterized by a distinct problem-solving agenda, physical and social complexity, and complex moral and ethical landscapes. In this endeavor, it arguably pushes scientific investigation beyond its usual comfort zones, raising fundamental issues about how best to structure such investigation. Philosophers of science have

IFPA Meeting 2013 Workshop Report III : Maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialised topics. At IFPA meeting 2013 there were twelve themed workshops, three of which are summarized in this report. These workshops related to various aspects of placental biology but collectively covered areas of placental function, cell turnover and immunology: 1) immunology; 2) novel determinants o

A novel nonneuronal catecholaminergic system : Exocrine pancreas synthesizes and releases dopamine

Cells of the exocrine pancreas produce digestive enzymes potentially harmful to the intestinal mucosa. Dopamine has been reported to protect against mucosal injury. In looking for the source of dopamine in the small intestine, we found that the duodenal juice contains high levels of dopamine and that the pancreas itself has a high dopamine [and dihydroxyphenylalanine (dopa)] content that does not

Genome-wide single nucleotide polymorphism markers reveal population structure and dispersal direction of an expanding nuisance algal bloom species

Species invasion and range expansion are currently under scrutiny due to increasing anthropogenic impact on the natural environment. This is also true for harmful algal blooms, which have been reported to have increased in frequency. However, this research is challenging due to the ephemeral nature, small size and mostly low concentrations of microalgae in the environment. One such species is the

Styrenic BAB triblock copolymers functionalized with lithium (N-tetrafluorophenyl)trifluoromethanesulfonamide as solid single-ion conducting electrolytes

Solid single-ion conducting electrolytes based on well-defined block copolymers show great potential for use in lithium batteries. Here, we report on triblock copolymers with an ion conductive poly(ethylene oxide) (PEO) center block and two flanking blocks of poly(lithium 2,3,5,6–tetrafluorostyrene-4-trifluoromethanesulfonamide). The copolymers were prepared through atom transfer radical polymeriz

Psychiatric Disorders and Cardiovascular Diseases During the Diagnostic Workup of Suspected Prostate Cancer

Background: It is unknown whether the rate of psychiatric disorders and cardiovascular disease increases during the diagnostic workup of suspected prostate cancer.Methods: We designed a population-based cohort study including 579 992 men living during 2005-2014 in Skåne, Sweden, according to the Swedish Total Population Register and the Skåne Healthcare Register (SHR). We used the Swedish Cancer R

Search for doubly and singly charged Higgs bosons decaying into vector bosons in multi-lepton final states with the ATLAS detector using proton-proton collisions at √s = 13 TeV

A search for charged Higgs bosons decaying into W±W± or W±Z bosons is performed, involving experimental signatures with two leptons of the same charge, or three or four leptons with a variety of charge combinations, missing transverse momentum and jets. A data sample of proton-proton collisions at a centre-of-mass energy of 13 TeV recorded with the ATLAS detector at the Large Hadron Collider betwe

Bit : An examination of the explanatory power of a meaning potential approach to the description of lexical meaning

Through a detailed examination of the use of the lexical item bit in four English language corpora, this study assesses whether the assumptions guiding a meaning potential perspective on lexical meaning (e.g. Allwood 1999, 2003; Croft and Cruse 2004, Paradis 2005; Fauconnier 2007) are reconcilable with a practicable description and explanation of attested language use. To this end, the study emplo

Electric bike (non)users’ health and comfort concerns pre and peri a world pandemic (COVID-19): A qualitative study

Introduction: The unprecedented COVID-19 pandemic affects different domains of society,including the transport system. Due to the impacts of social distancing, research concerningelectric bike (e-bike) applications and non(user) health and comfort concerns is needed. Thisresearch aims to understand the health and comfort concerns of e-bike (non)users in both pre (PR)and peri (PE) pandemic situatio

How does image quality affect radiologists’ perceived ability for image interpretation and lesion detection in digital mammography?

Objectives: To study how radiologists’ perceived ability to interpret digital mammography (DM) images is affected by decreases in image quality. Methods: One view from 45 DM cases (including 30 cancers) was degraded to six levels each of two acquisition-related issues (lower spatial resolution and increased quantum noise) and three post-processing-related issues (lower and higher contrast and incr

A shrine for the nation : The material transformation of the Lovćen site in Montenegro

Mount Lovćen holds significant cultural, political and religious symbolism in Montenegro, especially due to the fact that the mountain is the last resting place of the prince-bishop and national poet Petar II Petrovich-Njegoš (1813–1851). In the twentieth century the grave of Njegoš has undergone profound material transformations. Each of these transformations has led to heated debates about the s

Guiding Principles for Chronic Total Occlusion Percutaneous Coronary Intervention : A Global Expert Consensus Document

Outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) have improved because of advancements in equipment and techniques. With global collaboration and knowledge sharing, we have identified 7 common principles that are widely accepted as best practices for CTO-PCI. 1. Ischemic symptom improvement is the primary indication for CTO-PCI. 2. Dual coronary angiography and in

Adaptation of the charlson comorbidity index for register-based research in sweden

Purpose: Comorbidity indices are often used to measure comorbidities in register-based research. We aimed to adapt the Charlson comorbidity index (CCI) to a Swedish setting. Methods: Four versions of the CCI were compared and evaluated by disease-specific experts. Results: We created a cohesive coding system for CCI to 1) harmonize the content between different international classification of dise