Sökresultat

Filtyp

Din sökning på "*" gav 533191 sökträffar

Conceptual Basis for a Sustainable and Fire Resilient Built Environment

Fire has the potential to create significant impacts on the built environment. Managing this impact is sometimes pursued without consideration of the interface between the natural and technological worlds. However, as society has recognized the impacts of technological development on environmental sustainability, the need for sustainable and resilient development has emerged. To facilitate sustain

Multiclass risk models for ovarian malignancy : an illustration of prediction uncertainty due to the choice of algorithm

Background: Assessing malignancy risk is important to choose appropriate management of ovarian tumors. We compared six algorithms to estimate the probabilities that an ovarian tumor is benign, borderline malignant, stage I primary invasive, stage II-IV primary invasive, or secondary metastatic. Methods: This retrospective cohort study used 5909 patients recruited from 1999 to 2012 for model develo

Proteomic profiling of human menisci from mild joint degeneration and end-stage osteoarthritis versus healthy controls

Objective: To gain new insight into the molecular changes of the meniscus by comparing the proteome profiles of healthy controls with mild degeneration and end-stage osteoarthritis (OA). Method: We obtained tissue plugs from lateral and medial menisci of 37 individuals (central part of the posterior horn) classified as healthy (n ​= ​12), mild signs of joint damage (n ​= ​13) and end-stage OA (n ​

Efficacy of immune checkpoint inhibitors in alveolar soft-part sarcoma : results from a retrospective worldwide registry

Background: Conventional cytotoxic drugs are not effective in alveolar soft-part sarcoma (ASPS). Immune checkpoint (programmed cell death protein 1/programmed death-ligand 1) inhibitors (ICIs) are promising drugs in ASPS. A worldwide registry explored the efficacy of ICI in ASPS. Materials and methods: Data from adult patients diagnosed with ASPS and treated with ICI for advanced disease in expert

Mapping of peatlands in the forested landscape of Sweden using lidar-based terrain indices

Globally, northern peatlands are major carbon deposits with important implications for the climate system. It is therefore crucial to understand their spatial occurrence, especially in the context of peatland degradation by land cover change and climate change. This study was aimed at mapping peatlands in the forested landscape of Sweden by modelling soil data against lidar-based terrain indices.

Consensus recommendations for clinical assessment tools for the diagnosis of posterior cortical atrophy syndrome from the Atypical AD PIA of ISTAART

INTRODUCTION: Delay in diagnosis of posterior cortical atrophy (PCA) syndrome is common, and the lack of familiarity with assessment tools for identifying visual cortical dysfunction is a contributing factor. We propose recommendations for the approach to the evaluation of PCA clinical features during the office visit, the neuropsychological evaluation, and the research setting. A recommended scre

CT-based volumetric measures obtained through deep learning : Association with biomarkers of neurodegeneration

INTRODUCTION: Cranial computed tomography (CT) is an affordable and widely available imaging modality that is used to assess structural abnormalities, but not to quantify neurodegeneration. Previously we developed a deep-learning–based model that produced accurate and robust cranial CT tissue classification. MATERIALS AND METHODS: We analyzed 917 CT and 744 magnetic resonance (MR) scans from the G

At the frontlines of implementing the right to a healthy environment : Understanding human rights and environmental due diligence in relation to armed conflicts

Potential harm to human rights and the environment, including by corporate actors, is amplified in situations of conflict. This article focuses on applying the right to a healthy environment in relation to armed conflicts and corporate responsibility. In particular, it analyzes and compares due diligence requirements in the European Union Conflict Minerals Regulation and the International Law Comm

Cervical cancer in Region Skåne, Sweden 2017–2020 after the implementation of primary HPV screening : A quality assurance audit

Introduction: Primary human papilloma virus (HPV) screening to detect cervical cancer and dysplastic lesions was implemented in Region Skåne 2017 for women aged 30–70. The aim of this study was to characterize the screening history of women diagnosed with cervical cancer to evaluate the performance of the screening program, as well as to assess the cancer treatments given and shortcomings in the f

Gender and maladaptive personality correlates in problem gambling and over-indebtedness : Novel findings from a cross-sectional study in Sweden

Although most individuals consider gambling to be an innocent and fun activity, when it develops into problem gambling, it can have detrimental outcomes to one's life, such as over-indebtedness. This cross-sectional study explores the role of maladaptive personality traits and gender in both problem gambling and over-indebtedness, in an online sample of 1479 adult gamblers (65% males) in Sweden. P

Use of prescribed analgesics before and after exercise therapy and patient education in patients with knee or hip osteoarthritis

The aim of this study was to investigate utilisation patterns of prescribed analgesics before, during, and after an exercise therapy and patient education program among patients with knee or hip osteoarthritis. This cohort study is based on data from the nationwide Good Life with osteoarthritis in Denmark (GLA:D®) patient-register linked with national health registries including data on prescribed

Improved detection of clinically relevant fusion transcripts in cancer by machine learning classification

BACKGROUND: Genomic rearrangements in cancer cells can create fusion genes that encode chimeric proteins or alter the expression of coding and non-coding RNAs. In some cancer types, fusions involving specific kinases are used as targets for therapy. Fusion genes can be detected by whole genome sequencing (WGS) and targeted fusion panels, but RNA sequencing (RNA-Seq) has the advantageous capability

LGANet : Local-Global Augmentation Network for Skin Lesion Segmentation

Automatic segmentation of skin lesion is still challenging due to ambiguous boundary and noise interference of lesion regions. Recent exiting Transformer-based methods often directly apply Transformer to obtain long-range dependency to overcome these problems. However, they generally do not consider that patch partitioning strategy of Transformer could lead to the loss of local details around boun

3000 Years of past regional and local land-use and land-cover change in the southeastern Swedish coastal area : Early human-induced increases in landscape openness as a potential nutrient source to the Baltic Sea coastal waters

Reconstructions of past land use and related land-cover changes at local and regional scales are needed to evaluate the potential long-term impacts of land use on the coastal waters of the Baltic Sea. In this purpose, we selected the Gamleby area at the Swedish Baltic Sea coast for a case study. We use a new, high resolution pollen record from a small lake (Lillsjön) located 3.6 km NNW of the bay

Emad Elsewedy, Crisis Management Through the Lens of a Leader

Learning outcomes: This case study covers different concepts related to leadership. It should help students analyze business situations from a leader’s perspective. By the end of this case study, students would be able to understand the role and the characteristics of leadership during a crisis using the 11 dimensions of character framework, map leadership personalities using the HEXACO model to u

Contact allergy to oxidised geraniol may be over-represented in individuals with photocontact allergy to ketoprofen

Background: Simultaneous overrepresentations of contact allergies and photocontact allergies are common in individuals with photocontact allergy to ketoprofen. Aims: To investigate whether contact allergy to oxidised (ox.) geraniol, geraniol, geranial, neral and citral is overrepresented in individuals with photocontact allergy to ketoprofen. Methods: The contact allergy rates to ox. geraniol, ger