Aim: Earth observation-based estimates of land–atmosphere exchange of carbon are essential for understanding the response of the terrestrial biosphere to climatic change and other anthropogenic forcing. Temperature, soil water content and gross primary production are the main drivers of ecosystem respiration (Reco), and the main aims of this study are to develop an Reco model driven by long-term g

Objective: To determine the value of CT-guided bone core biopsy and investigate factors that affect diagnostic yield and biopsy outcome. Materials and methods: The single-centre retrospective analysis included 447 patients who had CT-guided core biopsy with a 13-G needle (Bonopty®) from January 2016 to December 2021. Histological results or ≥ 6 months of clinical and radiological follow-up served

Rapid advances in genomics have opened unprecedented possibilities to explore the mutational landscapes in malignant diseases, such as B-cell acute lymphoblastic leukemia (B-ALL). This disease is manifested as a severe defect in the production of normal blood cells due to the uncontrolled expansion of transformed B-lymphocyte progenitors in the bone marrow. Even though classical genetics identifie

This review addresses outstanding questions regarding initial pharmacological management of chronic obstructive pulmonary disease (COPD). Optimizing initial treatment improves clinical outcomes in symptomatic patients, including those with low exacerbation risk. Long-acting muscarinic antagonist/long-acting β2-agonist (LAMA/LABA) dual therapy improves lung function versus LAMA or LABA monotherapy,

Current asthma therapies focus on reducing symptoms but fail to restore existing structural damage. Mesenchymal stromal cell (MSC) administration can ameliorate airway inflammation and reverse airway remodeling. However, differences in patient disease microenvironments seem to influence MSC therapeutic effects. A polymorphic CATT tetranucleotide repeat at position 794 of the human macrophage migra

The Grande de Tárcoles River in Costa Rica is one of the most polluted and degraded river basins in Central America. At the same time Costa Rica is a country internationally recognized for progressive environmental management. At least on paper, the country fosters sustainable river management in the form of integrated water resources management (IWRM). In the specific case of the Grande de Tárcol

Priceless artworks are being destroyed or, at least, they appear to be. Yet the very act of climate protest targeting these works in what could be construed as acts of vandalism are in themselves productive of new visual media through which climate concern and urgency is conveyed. This article offers reflections upon one way in which these protest actions may be conceptually understood. It does so

Fyra manualer/riktlinjer har gåtts genom enligt internationella bästa praktik kriterier. Dessa fyra manualer/riktlinjer valdes då trafiksäkerhetsgranskning som en systematisk procedur startade i England och dess grundläggande principer förfinades i Australien. Det är också av intresse hur Sveriges grannländer, Danmark och Norge har utvecklat sina egna nationella manualer.

This paper presents the results of an experimental campaign designed to compare and understand the performance of passive protection under exposure to standard furnace tests and natural fires. As part of this campaign, five natural fire experiments were performed with partially protected cross-laminated timber (CLT) compartments under a range of ventilation conditions. In all the tests, only one s

Whereas the validity of deductive inferences can be characterized in terms of their logical form, this is not true for all inferences that appear pre-theoretically valid. Nonetheless, philosophers have argued that at least some of those inferences—sometimes called “similarity-based inferences” —can be given a formal treatment with the help of similarity spaces, which are mathematical spaces purpor

Swelling is the most fundamental property of graphite oxides (GO). Here, a structural study of Brodie graphite oxide (BGO) swelling in a set of long chain 1-alcohols (named C11 to C22 according to the number of carbons) performed using synchrotron radiation X-ray diffraction at elevated temperatures is reported. Even the longest of tested alcohols (C22) is found to intercalate BGO with enormous ex

Background: Respiratory virus infections are main triggers of asthma exacerbations. Tezepelumab, an anti-TSLP mAb, reduces exacerbations in patients with asthma, but the effect of blocking TSLP on host epithelial resistance and tolerance to virus infection is not known. Aim: To examine effects of blocking TSLP in patients with asthma on host resistance (IFNβ, IFNλ, and viral load) and on the airwa

An emissions barrier was used in premises with indoor air complaints due to emissions from the buildings in question. The emissions comprised chlorophenols/chloroanisoles and polycyclic aromatic hydrocarbons (PAH) from treated wood, volatile organic compounds (VOC) from PVC flooring and/or the glue used to paste the flooring onto a concrete slab, and radon from radium-containing aerated concrete.

A search for a new heavy scalar or pseudo-scalar Higgs boson (H/A) produced in association with a pair of top quarks, with the Higgs boson decaying into a pair of top quarks (H/A → tt¯) is reported. The search targets a final state with exactly two leptons with same-sign electric charges or at least three leptons. The analysed dataset corresponds to an integrated luminosity of 139 fb −1 of proton–

Background: Over the past years, it has become clear that the microbial ecosystem in the gut has a profound capacity to interact with the host through the production of a wide range of bioactive metabolites. The microbially produced metabolite imidazole propionate (ImP) is clinically and mechanistically linked with insulin resistance and type 2 diabetes, but it is unclear how ImP is associated wit

The flavour-tagging algorithms developed by the ATLAS Collaboration and used to analyse its dataset of s=13 TeV pp collisions from Run 2 of the Large Hadron Collider are presented. These new tagging algorithms are based on recurrent and deep neural networks, and their performance is evaluated in simulated collision events. These developments yield considerable improvements over previous jet-flavou