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Low level exposure to cadmium and early kidney damage : the OSCAR study

OBJECTIVES: To study the dose-response relation between cadmium dose and renal tubular damage in a population of workers and people environmentally or occupationally exposed to low concentrations of cadmium.METHODS: Early kidney damage in 1021 people, occupationally or environmentally exposed to cadmium, was assessed from cadmium in urine to estimate dose, and protein HC (alpha(1)-microglobulin) i

Synthesis and antibacterial properties of peptidyl derivatives and cyclopeptides structurally based upon the inhibitory centre of human cystatin C. Dissociation of antiproteolytic and antibacterial effects

Cysteine protease-inhibiting proteins of the cystatin superfamily can inhibit the replication of certain viruses and bacteria. The inhibitory centre of human cystatin C, the most widely distributed human cystatin, comprises three peptide segments. The present work describes the synthesis and antibacterial activity of 27 new peptidyl derivatives or cyclopeptides based upon the aminoterminal segment

Absence of cystatin C mutation in sporadic cerebral amyloid angiopathy-related hemorrhage

In Icelandic pedigrees a cystatin C mutation, glutamine 68 (L68Q), causes autosomal dominant cerebral amyloid angiopathy-related hemorrhage (CAAH). We examined 33 patients with sporadic CAAH for this mutation. None carried L68Q and, including this report, only one of 52 published cases of sporadic CAAH has had the cystatin C mutation. Despite vascular colocalization of cystatin C with amyloid beta

Biologiska museet listar nya arter för Sverige 2020

Botaniker donerar varje år tusentals pressade växter till Lunds universitets biologiska museum. Ibland handlar det om nyheter i Sveriges vilda flora. Nya för år 2020 är exempelvis prärielök, brittsommaraster och rosenfibbla.The first Swedish records of 19 taxa that first attracted attention in 2020 in the Lund Botanical Museum (LD) are reported and briefly discussed., viz. Allium ampeloprasum var. ampeloprasum, Allium cernuum, Arisaema amurense, Aster amellus, Crepis rubra, Cyclamen coum subsp. coum, Digitaria sanguinalis subsp. pectiniformis, Eleocharis cf. montevidensis, Fraxinus angustifolia, Helichrysum italicum,

FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor

We have purified and characterized a factor, from the conditioned medium of neural stem cell cultures, which is required for fibroblast growth factor 2's (FGF-2) mitogenic activity on neural stem cells. This autocrine/paracrine cofactor is a glycosylated form of cystatin C (CCg), whose N-glycosylation is required for its activity. We further demonstrated that, both in vitro and in vivo, neural ste

Cystatin C is Indispensable for Evaluation of Kidney Disease

The present minireview of the place of cystatin C in clinical medicine emphasizes, and discuss the evidence, that cystatin C-based GFR-estimating equations do not require the use of vague terms like race and sex, that cystatin C-based GFR-esti mating equations are useful for both children and adults, including the elderly, that the best GFR-estimation requires simultaneous use of both cystatin C-

Type 2 diabetes burden among migrants in Europe : unravelling the causal pathways

European populations are ethnically and culturally diverse due to international migration. Evidence indicates large ethnic inequalities in the prevalence of type 2 diabetes. This review discusses the burden of type 2 diabetes and its related complications, and the potential explanatory mechanisms among migrants in Europe. The current available data suggest that the rate of type 2 diabetes is highe

MicroRNA31 and MMP-1 contribute to the differentiated pathway of invasion -with enhanced epithelial-to-mesenchymal transition- in squamous cell carcinoma of the skin

Epithelial to mesenchymal transition (EMT) is an important mechanism of invasion in cutaneous squamous cell carcinomaas (cSCCs) and has been found to be enhanced in tumors originated from actinic keratosis with transformation limited to the basal epithelial layer -differentiated pathway-, compared to cases with invasion subsequent to complete epidermal transformation -classical pathway-. Several m

Strategies for greening the economy in three Nordic countries

Green economy is a concept frequently used by governments and international institutions to promote sustainable transformations of the economy. In this study, we explore how the transition towards a green economy is being conceptualised in policy terms in the three Nordic countries Denmark, Norway, and Sweden. Comparing these cases, we analyse strategic policy documents on green growth, circular e

Anorectal malformations – surgical aspects and transition

Background: Anorectal malformations (ARM) occur in 1/5000 live births (1.2–1.6:1 male:female). Associated malformations are common, influencing, together with ARM-subtype complexity, long-term outcome, follow-up and need of transitional care. Reconstructive surgery, the posterior sagittal anorectoplasty (PSARP), is performed in infancy, either as a single-stage or multi-stage procedure with a colo

Nanoparticle-Assisted Pool Boiling Heat Transfer on Micro-Pin-Fin Surfaces

Boiling heat transfer intensification is of significant relevance to energy conversion and various cooling processes. This study aimed to enhance the saturated pool boiling of FC-72 (a dielectric liquid) by surface modifications and explore mechanisms of the enhancement. Specifically, circular and square micro pin fins were fabricated on silicon surfaces by dry etching and then copper nanoparticle

Measured glomerular filtration rate does not improve prediction of mortality by cystatin C and creatinine

Background: Cystatin C may add explanatory power for associations with mortality in combination with other filtration markers, possibly indicating pathways other than glomerular filtration rate (GFR). However, this has not been firmly established since interpretation of associations independent of measured GFR (mGFR) is limited by potential multicollinearity between markers of GFR. The primary aim

CKD : A Call for an Age-Adapted Definition

Current criteria for the diagnosis of CKD in adults include persistent signs of kidney damage, such as increased urine albumin-to-creatinine ratio or a GFR below the threshold of 60 ml/min per 1.73 m2 This threshold has important caveats because it does not separate kidney disease from kidney aging, and therefore does not hold for all ages. In an extensive review of the literature, we found that G