Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition

To keep global warming within 1.5 °C of pre-industrial levels, there needs to be a substantial decline in the use of coal power by 20301,2 and in most scenarios, complete cessation by 2050. The members of the Powering Past Coal Alliance (PPCA), launched in 2017 at the UNFCCC Conference of the Parties, are committed to “phasing out existing unabated coal power generation and a moratorium on new coa

Purpose: The purpose of this paper is to study the effects of dimple geometries and arrangements on the heat transfer enhancement in a dimple jacketed heat exchanger. Design/methodology/approach: For the purpose of this paper, with the experimental validated numerical model, this paper carries out numerical simulations of both single dimples with different geometries and the whole dimple jacketed

Parkinson’s disease (PD) affects 2–3% of the population over the age of 65 with loss of dopaminergic neurons in the substantia nigra impacting the functioning of basal ganglia-thalamocortical circuits. The precise role played by the thalamus is unknown, despite its critical role in the functioning of the cerebral cortex, and the abnormal neuronal activity of the structure in PD. Our objective was

The latitudinal diversity gradient (LDG) is one of Earth’s most iconic biodiversity patterns and still one of the most debated. Explanations for the LDG are often categorized into three broad pathways in which the diversity gradient is created by (1) differential diversification rates, (2) differential carrying capacities (ecological limits), or (3) differential time to accumulate species across l

The effects of ethanol in the rat on the absorption and incorporation of 3H-arachidonic (20: 4, n-6) and 14C-linoleic acid (18:2, n-6) into tissue lipids was examined in jejunal tissue cultures in vivo. The pattern of incorporation earlier seen in the small intestine in vivo, ie. a preferential incorporation of 3H-20: 4 in comparison to 14C-18: 2 into phospholipids (PL), particularly phosphatidyle

Artificial groundwater recharge is commonly used for drinking water supply. The resulting water quality is highly dependent on the raw water quality. In many cases, pre-treatment is required. Pre-treatment improves the drinking water quality, although how and to what extent it affects the subsequent pond water quality and infiltration process, is still unknown. We evaluated two treatment systems b

Här granskas ett stickprov på cirka ett halvt tusen brev skrivna till statsministern under 1992–95 i syfte att kartlägga brevskrivarnas uppfattning om hur svensk ekonomi och ekonomisk politik fungerar. Urvalet omfattar såväl brev adresserade till en borgerlig statsminister, Carl Bildt, som till en socialdemokratisk, Ingvar Carlsson.Av breven framgår att rättvisa och fördelning är långt mer central

The laser wake-field accelerator (LWFA) traditionally produces high brightness, quasi-monoenergetic electron beams with Gaussian-like spatial and angular distributions. In the present work we investigate the generation of ultra-relativistic beams with ring-like structures in the blowout regime of the LWFA using a dual stage accelerator. A density down-ramp triggers injection after the first stage

The minimum weighted edge dominating set problem (MWEDS) generalizes both the weighted vertex cover problem and the problem of covering the edges of graph by a minimum cost set of both vertices and edges. In this paper, we propose a meta heuristic approach based on genetic algorithm and local search to solve the MWEDS problem. Therefore, the proposed method is considered as a memetic search algori

Background: Aneurysmal subarachnoid haemorrhage (SAH) is a variant of haemorrhagic stroke with a striking 50% mortality rate. In addition to the initial insult, secondary delayed brain injury may occur days after the initial ischemic insult and is associated with vasospasms leading to delayed cerebral ischemia. We have previously shown that the MEK1/2 inhibitor U0126 improves neurological assessme

Ett generellt problem för professorn är att finna en lämplig avvägning mellan rollen som oberoende bedömare av samhällsutvecklingen och rollen som expert eller konsult åt externa uppdragsgivare. Detta dilemma diskuteras här med utgångspunkt från den växande kopplingen mellan professorskåren inom nationalekonomi och den offentliga sektorn under de senaste 10–15 åren. Någon enkel lösning på motsättn

Assembly of the mitochondrial respiratory chain requires the coordinated synthesis of mitochondrial and nuclear encoded subunits, redox co-factor acquisition, and correct joining of the subunits to form functional complexes. The conserved Cbp3-Cbp6 chaperone complex binds newly synthesized cytochrome b and supports the ordered acquisition of the heme co-factors. Moreover, it functions as a transla