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Background: The mast cell-specific metalloprotease CPA3 has been given important roles in lung tissue homeostasis and disease pathogenesis. However, the dynamics and spatial distribution of mast cell CPA3 expression in lung diseases remain unknown. Methods: Using a histology-based approach for quantitative spatial decoding of mRNA and protein single cell, this study investigates the dynamics of CP

Three metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins (Pattern

The building industry has a major environmental impact in terms of global energy use, carbon emissions, resource use, and the production of waste. To reach ambitious international environmental goals, the building industry faces a need for large-scale change. Circular strategies for buildings include using building and materials longer through lifetime extension strategies, reuse, sharing, renovat

Introduction: Successful aging is a multidimensional construct covering behavioral, social, and psychological domains of well-being. We aimed to identify well-being profiles and their association with mobility-limitation free survival. Methods: A total of 1488 healthy individuals aged 60+ from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) were followed-up for 15 years. Mobil

Experimental data on pulmonary regurgitation has linked right ventricular longitudinal function to left ventricular filling pressure in animals with induced and treated pulmonary regurgitation but this relationship has not been investigated in patients with repaired Tetralogy of Fallot (rToF). The aim of this study was to determine if right ventricular longitudinal function assessed using cardiova

Kort introduktion till Toni Rønnow-Rasmussens bok The Value Gap (OUP 2022)

The purpose of this study is to investigate how a regional knowledge base of information and communication technologies (ICTs) influences the emergence of artificial intelligence (AI) technologies in European regions. Relying on patent data and studying the knowledge production of AI technologies in 233 European regions in the period from 1994 to 2017, our study reveals three results. First, ICTs

The molecular mechanisms regulating key fate decisions of hematopoietic stem cells (HSCs) remain incompletely understood. Here, we targeted global shRNA libraries to primary human hematopoietic stem and progenitor cells (HSPCs) to screen for modifiers of self-renewal and differentiation, and identified metastasis-associated 1 (MTA1) as a negative regulator of human HSPC propagation in vitro. Knock

Quantified indicators are increasingly used for performance evaluations in the science sectors worldwide. However, relatively little information is available on the expanding use of research metrics in certain transition countries. Central Asia is a post-Soviet region where newly independent states achieved lower research performance relative to comparators in key indicators of productivity and in

Water is a key element for wood performance, as water molecules interact with the wood structure and affect important material characteristics such as mechanical properties and durability. Understanding wood-water interactions is consequently essential for all applications of wood, including the design of wood materials with improved durability by chemical modification. In this work, we used Raman

Current scholarship on race in Europe has described race as an “absent presence”. However, little is known about the dynamics of the absentness and presentness of race, including how various social processes operating at distinct levels (e.g., supranational and national) influence the uses of race and ethnicity concepts. We begin addressing this gap by examining racialised pharmaceutical regulatio

This paper studies how degraded material properties in near proximity to the cut edge influence the torque performance of an axial-flux induction machine. The magnetically degraded areas are characterized using a layering approach, where the magnetic hysteresis curve describing the material is remodeled so that the field strength required to reach a specific value of magnetic flux density is incre

Kvinnors utrymme i läroböcker i historia.

Kvinnor i konsumtionskulturen kring 1900. Annonser, kvinno-, genushistoria.

This document presents a tutorial on case study research methodology in software engineering, held at the 10th International Conference on Product Focused Software Development and Process Improvement (Profes).