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Chromosomal rearrangements involving Janus kinase 2 (JAK2) are rare but recurrent findings in lymphoid or myeloid neoplasia. Detection of JAK2 fusion genes is important as patients with aberrantly activated JAK2 may benefit from treatment with tyrosine kinase inhibitors such as ruxolitinib. Here, we report a novel fusion gene between the transcriptional co-repressor-encoding gene transducin-like e

In times of escalating global environmental crises and subsequent troubling emotional experiences, it is imperative to understand the psychological mechanisms through which people cope. Although it is increasingly recommended to talk about global environmental change and the emotions it evokes as a way of coping with its overwhelming and existential nature, private-sphere conversations about clima

We have studied the conversion of two molecules of carbon monoxide to ethylene catalyzed by nitrogenase. We start from a recent crystal structure showing the binding of two carbon monoxide molecules to nitrogenase and employ the combined quantum mechanics and molecular mechanics approach. Our results indicate that the reaction is possible only if S2B dissociates as H2S (i.e., the charge of the FeM

Denna avhandling är en kvalitativ, livshistorisk och narrativ studie som undersöker hur 19 vuxna transmaskulina personer i Johannesburg och Kapstaden, Sydafrika, navigerar och förhandlar fram hållbara liv i de miljöerna de lever och rör sig i. Studiens teoretiska ramverk bygger på teoretiska inslag från feministisk geografi, queerfenomenologi, svart transfeminism och analyser av rasifierad kapitalThis dissertation is a qualitative, life history/narrative study that explores how 19 adult trans masculine people living in different urban areas around Johannesburg and Cape Town, South Africa, navigate and negotiate liveable lives in the spaces and places they live and move in. This study draws from the theoretical and analytical traditions of feminist geographies, queer phenomenology, black tr

Hybrid zone movement may result in substantial unidirectional introgression of selectively neutral material from the local to the advancing species, leaving a genetic footprint. This genetic footprint is represented by a trail of asymmetric tails and displaced cline centres in the wake of the moving hybrid zone. A peak of admixture linkage disequilibrium is predicted to exist ahead of the centre o

The Earth Hologenome Initiative (EHI) is a global collaboration to generate and analyse hologenomic data from wild animals and associated microorganisms using standardised methodologies underpinned by open and inclusive research principles. Initially focused on vertebrates, it aims to re-examine ecological and evolutionary questions by studying host–microbiota interactions from a systemic perspect

Ecological genomics approaches have informed us about the structure of genetic diversity in natural populations that might underlie patterns in trait variation. However, we still know surprisingly little about the mechanisms that permit organisms to adapt to variable environmental conditions. The salt marsh foundation plant Spartina alterniflora exhibits a dramatic range in phenotype that is assoc

We developed a panel of 44 nuclear genetic markers and applied this to two hybridizing species of marbled newts in the north (Triturus marmoratus) and the south (Triturus pygmaeus) of the Iberian Peninsula, to investigate pattern and process of interspecific gene flow. The northernmost occurrence of T. pygmaeus genetic material was in a T. marmoratus population north of the Vouga river estuary. Th

The three species of banded newt (genus Ommatotriton) are endemic to the Near East. Recently an introduced banded newt population was discovered in Catalonia, Spain. To determine the species involved and the geographical source, we genotyped 11 individuals for one mitochondrial and two nuclear genetic markers, and compared the observed haplotypes to a range-wide phylogeography of Ommatotriton. All

Secondary contact between closely related species can lead to the formation of hybrid zones, allowing for interspecific gene flow. Hybrid zone movement can take place if one of the species possesses a competitive advantage over the other, ultimately resulting in species replacement. Such hybrid zone displacement is predicted to leave a genomic footprint across the landscape in the form of asymmetr

Peptide mass fingerprinting of bone collagen (ZooMS) has previously been proposed as a method to calculate the extent of the non-enzymatic degradation of glutamine into glutamic acid (deamidation). Temporal and spatial variation of glutamine deamidation at a single site, however, has not been investigated. Here we apply ZooMS screening of Châtelperronian and Early Holocene bone specimens from Quin

The banded newt (genus Ommatotriton) is widely distributed in the Near East (Anatolia, Caucasus and the Levant) – an understudied region from the perspective of phylogeography. The genus is polytypic, but the number of species included and the phylogenetic relationships between them are not settled. We sequenced two mitochondrial and two nuclear DNA markers throughout the range of Ommatotriton. Fo

Background: Previous research suggest that autistic children look less at faces than neurotypically developing children, but this finding is based predominantly on screen-based eye tracking studies, with unfamiliar faces used as stimuli. The aim of the current study was to assess 10-month-olds’ gaze to faces in a more naturalistic context - during free play with a parent - in relation to later aut

A Swedish translation of the patient-reported outcome measure for assessing long-term control of atopic der-matitis, Recap of atopic eczema (RECAP), has not been validated. Cross-cultural translation and multi-centre validation of the translated RECAP questionnaire were therefore performed. Disease severity was assessed using the validated Investigator Global Assessment Scale for atopic dermatitis

Recent research suggests that to help their preferred coalition win an election, voters are willing to vote for a political party other than their preferred choice. In this field, voting for smaller parties under proportional representation is an under-studied feature. A crucial factor to estimate the chances for smaller parties is polls. In this study, we analyze the influence of opinion polls on

This essay focuses on the reception of Pauline ideas in the Pseudo-Clementine Homilies, commonly dated to the early fourth century. At first, the claim that the Pseudo-Clementine Homilies contain Pauline ideas may seem surprising, since the Homilies are commonly considered “Jewish Christian” and thus anti-Pauline. However, new readings of Paul generated by the “Paul within Judaism” perspective, al

Experiments using the Surface Force Apparatus (SFA) have found anomalously long-ranged charge–charge underscreening in concentrated salt solutions. Meanwhile, theory and simulations have suggested ion clustering to be a possible origin of this behavior. The popular Restricted Primitive Model of electrolyte solutions, in which the solvent is represented by a uniform relative dielectric constant, εr

The creator economy features a pertinent, growing role of content creators and -viewers, revealing this service sub-sector’s rising economic, and strategic, contribution. In parallel, though the customer/stakeholder journey concepts are gaining traction, little is known about the interdependence characterizing online content creators’ and viewers’ (users’) engagement through their respective role-