Background: Neuroinflammation is implicated in the pathophysiology of Parkinson's disease (PD) and related conditions, yet prior clinical biomarker data report mixed findings. Objectives: The aim was to measure a panel of neuroinflammatory acute phase response (APR) proteins in the cerebrospinal fluid (CSF) of participants with PD and related disorders. Methods: Eleven APR proteins were measured i

Måltidskulturer påverkar alla situationer där lagande, ätande ochdrickande förekommer. Trots detta tas måltidskulturella aspektersällan i beaktande i det praktiska arbetet med professionella måltideri Sverige. Med en ökad kunskap om måltidskultur är det möjligt attdesigna måltider som tilltalar och skänker mening till gäster medolika bakgrund, ideal och preferenser. Det finns därför en storpotenti

This thesis concerns the nature of cognition. It posits that cognitive processes primarily are means to maintain allostasis in organisms whose ecological niches require movement to approach food-resources and avoid predation. Hence triggering, or motivation, of behaviours are a consequence of prediction errors from the body resulting from biological variables moving away from homeostasis. Dependin

Lung transplantion (LTx) recipients have low long-term survival and a high incidence of bronchiolitis obliterans syndrome (BOS), an inflammation of the small airways in chronic rejection of a lung allograft. There is great clinical need for a minimally invasive biomarker of BOS. Here, 644 different proteins were analyzed to detect biomarkers that distinguish BOS grade 0 from grades 1-3. The plasma

Rising demand for food production poses a major threat to biodiversity by placing competing pressures on land. Diversified farming systems are one widely promoted nature-based solution to this challenge, which aim to integrate biodiversity-based ecosystem services into agricultural production. The underlying theory behind this approach is that diverse communities enhance ecosystem service provisio

Type 2 diabetes (T2D) is characterised by defective insulin exocytosis from the pancreatic β cells, accompanied by insulin resistance. Reduced β cells mass is often seen in T2D individuals, caused by enhanced β cells apoptosis. It is now understood that several components drive β cells dysfunction and apoptosis. These are glucose-and lipo-toxicity, ER stress, pro-inflammatory cytokines, dysfunctio

How to approach the complex intellectual legacy of a modern Muslim thinker like Muhammad ‘Abduh (1849-1905)? This book offers an answer to this question by providing a new complete intellectual biography of him. It delineates ‘Abduh’s formation as a reformer and activist and embeds his varied intellectual contributions in a culture of ambiguity which has marked the intellectual life of Muslim soci

OBJECTIVE: The purpose was to test the hypothesis that the HLA-DQαβ heterodimer structure is related to the progression of islet autoimmunity from asymptomatic to symptomatic type 1 diabetes (T1D).RESEARCH DESIGN AND METHODS: Next-generation targeted sequencing was used to genotype HLA-DQA1-B1 class II genes in 670 subjects in the Diabetes Prevention Trial-Type 1 (DPT-1). Coding sequences were tra