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The building sector is a major contributor to greenhouse gases, consuming significant energy and available resources. Energy renovation of buildings is an effective strategy for decarbonisation, as it lowers operational energy and avoids the embodied impact of new constructions. To be successful, the energy renovation process requires meaningful building models. However, the time and costs associa

Therapy resistance remains one of the major challenges for cancer treatment that largely limits treatment benefits and patient survival. The underlying mechanisms that lead to therapy resistance are highly complicated because of the specificity to the cancer subtype and therapy. The expression of the anti-apoptotic protein BCL2 has been shown to be deregulated in T-cell acute lymphoblastic leukemi

The recent emergence of deep learning and computer vision-based 3D human pose estimation presents opportunities for a form of markerless motion-capture. State-of-the-art approaches have achieved remarkable accuracy in predicting global and relative joint positions, however, many potential applications require information on joint orientations, e.g., in the fields of biomechanics. Furthermore, meth

The self-protective effects of active response in unplanned falls is a well-established, yet under-researched area. Our recent study demonstrated how single cyclist falls are prevalent (i.e., cyclist road traffic collisions not involving another road user), and that active response is of particular importance in these cases. This phenomenon has not been considered in previous computational modelli

Cyclist underreporting of lower severity and single cyclist collisions to police results in the underestimation of the societal costs of lower severity and single cyclist collisions. Prevention strategies for these types of collisions are becoming a popular area of research, and video-based approaches have obvious potential for these cases, allowing for detailed analyses of underreported lower sev

Background: Primary graft failure (PGF) remains the most common cause of short-term mortality after heart transplantation. The main objective was to develop and validate a risk model for prediction of short-term mortality due to PGF after heart transplantation using the ISHLT Heart Transplant Registry. Methods: We developed a non-linear artificial neural networks (ANN) model to evaluate the associ

This article analyses how UN Security Council resolution 1325 and the Women, Peace, Security (WPS) agenda have been adopted in the Middle East and North Africa. The region faces huge security challenges triggered by recurrent armed conflicts, terrorism and wars both between and within states. Four thematic areas have been chosen: (1) terrorism; (2) peace negotiations; (3) state-building; and (4) d

The paper examines the limits of state interference in proscribing cultural norms by considering gender discrimination, right of people to leave their community free of penalties, denying women appropriate education, and forced or arranged marriages for girls and young women. The discussion opens by reflecting on the discriminatory practices of the Pueblo tribes against their women and analysing a

När medborgare vill gå samman och äga och producera energi gemensamt finns det olika sätt att organisera det på. I den här community briefen presenterar vi fem olika modeller av energigemenskaper. Modellerna baseras på en analys av 12 existerande solenergigemenskaper i Sverige. Genom att presentera de olika modellerna för delat ägande av förnybar energi hoppas vi kunna inspirera fler att etablera

In the present paper, an approach for updating the continuous stress range distribution of a welded connection of a wind turbine support structure with predicted information from strain measurements is presented. Environmental conditions, such as wind or, in offshore fields, waves and currents, in combination with rotor excitations generate cyclic stresses affecting the reliability of welded joint

Membranous glomerulonephritis (MGN) is a common cause of nephrotic syndrome in adults, mediated by glomerular antibody deposition to an increasing number of newly recognised antigens. Previous case reports have suggested an association between patients with anti-contactin-1 (CNTN1)-mediated neuropathies and MGN. In an observational study we investigated the pathobiology and extent of this potentia

Context. With its origin coming from several sources (Big Bang, stars, cosmic rays) and given its strong depletion during its stellar lifetime, the lithium element is of great interest as its chemical evolution in the Milky Way is not well understood at present. To help constrain stellar and galactic chemical evolution models, numerous and precise lithium abundances are necessary for a large range

The information on Galactic assembly time is imprinted on the chemodynamics of globular clusters. This makes them important probes that help us to understand the formation and evolution of the Milky Way. Discerning between in-situ and ex-situ origin of these objects is difficult when we study the Galactic bulge, which is the most complex and mixed component of the Milky Way. To investigate the ear

MAXPEEM, a dedicated photoemission electron microscopy beamline at MAX IV Laboratory, houses a state-of-the-art aberration-corrected spectroscopic photoemission and low-energy electron microscope (AC-SPELEEM). This powerful instrument offers a wide range of complementary techniques providing structural, chemical and magnetic sensitivities with a single-digit nanometre spatial resolution. The beaml

We explore the energetics of microwaves interacting with a double quantum dot photodiode and show wave-particle aspects in photon-assisted tunneling. The experiments show that the single-photon energy sets the relevant absorption energy in a weak-drive limit, which contrasts the strong-drive limit where the wave amplitude determines the relevant-energy scale and opens up microwave-induced bias tri

High- and low-latitude climatic processes in the North Pacific Ocean are important components of the global climate system. For example, the interplay among North Pacific atmospheric circulation, ocean circulation, and biological productivity affects atmospheric carbon dioxide levels and marine oxygen concentrations. Here we review recent research on the North Pacific paleoclimatic and paleoceanog

Development of drug resistance is a mounting problem in precision oncology, demanding a rethink of treatment strategy. We here apply concepts from military theory and espionage to the battle-like dynamics between cancer and its host, thereby identifying system vulnerabilities in cancer and ways of tricking cancer’s evolution into dead ends.

Eyeblink conditioning is used in many species to study motor learning and make inferences about cerebellar function. However, the discrepancies in performance between humans and other species combined with evidence that volition and awareness can modulate learning suggest that eyeblink conditioning is not merely a passive form of learning that relies on only the cerebellum. Here we explored two wa

RATIONALE: This case report describes the application of a novel gait retraining approach to an individual with poststroke hemiparesis. The rehabilitation protocol combined a specially designed leg orthosis (the gravity-balanced orthosis), treadmill walking, and functional electrical stimulation to the ankle muscles with the application of motor learning principles. CASE: The participant was a 58-