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Infant acute lymphoblastic leukemia (ALL) with KMT2A-gene rearrangements (KMT2A-r) have few mutations and a poor prognosis. To uncover mutations that are below the detection of standard next-generation sequencing (NGS), a combination of targeted duplex sequencing and NGS was applied on 20 infants and 7 children with KMT2A-r ALL, 5 longitudinal and 6 paired relapse samples. Of identified nonsynonym

A complete understanding of how exposure to environmental substances promotes cancer formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two-step process: an initiating step that induces mutations in healthy cells, followed by a promoter step that triggers cancer development1. Here we propose that environmental particulate matter measuring ≤2.5 μm (PM2.5), known

OBJECTIVE: To determine biological variation of the aggrecanase-generated aggrecan ARGS neoepitope in serum (sARGS) and synovial fluid (sfARGS) within and between patients with osteoarthritis (OA) or anterior cruciate ligament (ACL) injury.DESIGN: Matched samples of serum and synovial fluid were available, as parts of clinical trials, from i) 16 subjects with early-stage OA on 8 occasions over 1 y

The plasma proteome can provide a deeper understanding of the pathophysiology of different diseases and is a key source for detection of new biomarkers. Proximity extension assay (PEA), developed by Olink Proteomics (Uppsala, Sweden), detects proteins by using pairs of antibodies that are linked to oligonucleotides; upon target binding, the probes anneal when in proximity and the oligonucleotides

IMPORTANCE: Discontinuation and nonpublication are established sources of avoidable waste among surgical trials, but rates of delayed completion and recruiting shortfalls remain unclear.OBJECTIVES: To examine the rate of delayed completion, incomplete enrollment, and discontinuation among randomized clinical trials in surgical populations and the duration of delays and extent of recruiting shortfa

BACKGROUND: The shortage of trained surgeons, anesthesiologists, and obstetricians is a major contributor to the unmet need for surgical care in low- and middle-income countries, and the shortage is aggravated by migration to higher-income countries.METHODS: We performed a cross-sectional observational study, combining individual-level data of 43,621 physicians from the Health Professions Council

Background. A once commonly held belief was that surgery is too complicated, too expensive, and too ineffectively addressing a too minor proportion of the burden of disease to deserve priority in a setting of scarce healthcare resources in low- and middle-income countries. Yet, essential surgical care can be as highly cost-effective as other common public health interventions, and surgical service

Technical Analysis to Inform the Trigger Design for Adaptive Safety Nets in Malawi 2023 has been prepared by the Finance, Competitiveness & Innovation Global Practice’s Crisis, and Disaster Risk Finance team in collaboration with Tetra Tech, who acted as technical advisors for the World Bank. Funding and expertise were provided by the Disaster Protection Program (funded by the UK) and from the

Phytoglobins (Pgb) (plant hemoglobins) are heme-containing proteins and less well known in comparison to the mammalian counterparts hemoglobin (Hb) andmyoglobin (Mb). They share the same secondary structure as other globin-related proteins, six to eight α-helices comprising the myoglobin-fold (Mb-fold) with one prosthetic heme moiety per subunit. Pgbs are divided into different classes, where the Phytoglobins (Pgb) (plant hemoglobins) are heme-containing proteins and less well known in comparison to the mammalian counterparts hemoglobin (Hb) andmyoglobin (Mb). They share the same secondary structure as other globin-related proteins, six to eight α-helices comprising the myoglobin-fold (Mb-fold) with one prosthetic heme moiety per subunit. Pgbs are divided into different classes, where the

Large igneous provinces (LIPs) and especially their dyke swarms are pivotal to reconstruction of ancient supercontinents. The Dharwar craton of southern Peninsular India represents a substantial portion of Archean crust and has been considered to be a principal constituent of Superia, Sclavia, Nuna/Columbia and Rodinia supercontinents. The craton is intruded by numerous regional-scale mafic dyke s

This paper addresses possibilities and challenges on the methodological level during the initial phase of a practice-based research project. The research project aims to contribute to knowledge about pupils’ participation and influence in decision-making from the perspectives of teachers, leaders, and pupils in Sweden’s Art and Music Schools. A further aim is to contribute to the development of pr

This study focuses on policy conditions for collaboration between kulturskolor and comprehensive schools, as a strategy for children’s access to arts education. National policy documents address inclusion and widening participation as key issues for Swedish kulturskolor. The government has introduced grants for programme development with inclusion as one criterion for approval. Recent research has

Multiple concepts for future generations of wireless communication standards utilize coherent processing of signals from many distributed antennas. Names for these concepts include distributed MIMO, cell-free massive MIMO, XL-MIMO, and large intelligent surfaces. They aim to improve communica- tion reliability, capacity, as well as energy efficiency and provide possibilities for new applications t

Optimisation of cultivation conditions in the industrial production of probiotics is crucial to reach a high-quality product with high probiotic functionality. The production process includes a fermentation step to produce biomass, accompanied by centrifugation to concentrate the cells. Subsequently, the cells are treated with stabilising solutions (lyoprotectants) before they are subjected to fre

The conserved ESX-1 type VII secretion system is a major virulence determinant of pathogenic mycobacteria, including Mycobacterium tuberculosis and Mycobacterium marinum. ESX-1 is known to interact with infected macrophages, but its potential roles in regulating other host cells and immunopathology have remained largely unexplored. Using a murine M. marinum infection model, we identify neutrophils