Purpose: Cyclin D1 has a central role in cell cycle control and is an important component of estrogen regulation of cell cycle progression. We have previously shown that high cyclin D expression is related to aggressive features of ER-positive but not ER-negative breast cancer. The aims of the present study were to validate this differential ER-related effect and furthermore explore the relationsh

Secondary metabolites from fungi have become a major source of chemical innovation in programs searching for lead molecules with bioactivities, especially over the last 50 years. In this review, we discuss the fundamental considerations in the discovery of molecules for agricultural and medicinal uses. This group of organisms possesses a strong potential for scientific and industrial communities.

Measurements of normalized differential cross-sections of top-quark pair production are presented as a function of the top-quark, tt¯ system and event-level kinematic observables in proton–proton collisions at a centre-of-mass energy of s=8TeV. The observables have been chosen to emphasize the tt¯ production process and to be sensitive to effects of initial- and final-state radiation, to the diffe

During the pregnancy associated syndrome preeclampsia (PE), there is increased release of placental syncytiotrophoblast extracellular vesicles (STBEVs) and free foetal haemoglobin (HbF) into the maternal circulation. In the present study we investigated the uptake of normal and PE STBEVs by primary human coronary artery endothelial cells (HCAEC) and the effects of free HbF on this uptake. Our resu

En diskussion av filmmusikkompositören Bernard Herrmanns musik. Herrmann, som är mest känd för sitt samarbete med Orson Welles och Alfred Hitchcock, skapade en musik som mer än andra kompositörer satte sin unika prägel på de projekt han var involverad i. Texten diskuterar hans sätt a skapa ett samspel mellan ljud och bild genom att bryta upp musikens ledmotiv i mindre, kortare, fraser, för att på

The text emphasizes aesthetics in post war American film and is more precisely a study of directors, which started their career within live television and made a transition to cinema. The influence of their television background on their films is central to the text. Contributing factors in this context are changes in the overall technology within TV, changes from live productions to the use of fi

In this paper we consider the estimation of the weights of optimal portfolios from the Bayesian point of view under the assumption that the conditional distributions of the logarithmic returns are normal. Using the standard priors for the mean vector and the covariance matrix, we derive the posterior distributions for the weights of the global minimum variance portfolio. Moreover, we reparameteriz

BACKGROUND: Children are being infected by HIV/AIDS mainly through mother-to-child transmission. In Ethiopia currently more than 135,000 children are living with HIV/AIDS. The aim of this study was to describe the pattern of ARV uptake after birth, co-trimoxazole prophylaxis and follow up compliance, and to examine which factors are associated with the intervention outcome.METHODS: A retrospective

Oxidation of SO2.nH2O/HSO3-/SO32- by Pt(CN)4Cl22- has been studied at 25-degrees-C and 1.0 M ionic strength in acidic aqueous solution by use of stopped-flow spectrophotometry. The stoichiometry of the reaction is 1:1 according to Pt(CN)4Cl22- + HSO3 + H2O --> Pt(CN)42- + 2Cl- + HSO4- + 2H+. It is first-order with respect to both [Pt(IV)] and [S(IV)]. The pH-dependence in the region 0.3 < pH < 4.5

Platinum(II) complexes of the type [Pt(thioether)2Cl]+(thioether = dimethyl sulfide, thioxane) are capable of abstracting a phenyl group from the BPh4 counterion with formation of trans[Pt(thioether)2ClPh] compounds. Thermal reactions proceed both in the solid phase and in nitromethane solution at elevated temperature and have preparative importance. Phenylation of the Pt(II) centre also occurs inPlatinum(II) complexes of the type [Pt(thioether)2Cl]+(thioether = dimethyl sulfide, thioxane) are capable of abstracting a phenyl group from the BPh4 counterion with formation of trans[Pt(thioether)2ClPh] compounds. Thermal reactions proceed both in the solid phase and in nitromethane solution at elevated temperature and have preparative importance. Phenylation of the Pt(II) centre also occurs in

Marine energy technologies can contribute to meeting sustainability challenges, but they are still immature and dependent on public support. This paper employs the Technological Innovation Systems (TIS) framework to analyze the development and diffusion of Swedish marine energy up until 2014. While there were promising device developers, relevant industrial capabilities, and world-class research,

The resource-based view explains firms’ value appropriation in buyer-supplier relationships by pointing to sustained differences in economic efficiency across firms. Firms with more efficient resources create more value than competitors, which in turn provides a “protective cushion” against price-/quality competition. However, just as firms may differ in the economic efficiency of their resources

Ligand exchange on square-planar Pt(1,4-dithiane)2(2+), Pd(1,4-dithiane)2(2+), and Pt(Me2S)4(2+) has been studied as a function of temperature and pressure by H-1 NMR line-broadening, isotopic labeling, and magnetization transfer experiments with deuteriated nitromethane as solvent. Second-order rate constants and activation parameters are as follows: for 1,4-dithiane exchange on Pt(1,4-dithiane)2Ligand exchange on square-planar Pt(1,4-dithiane)2(2+), Pd(1,4-dithiane)2(2+), and Pt(Me2S)4(2+) has been studied as a function of temperature and pressure by H-1 NMR line-broadening, isotopic labeling, and magnetization transfer experiments with deuteriated nitromethane as solvent. Second-order rate constants and activation parameters are as follows: for 1,4-dithiane exchange on Pt(1,4-dithiane)2

Structure and dynamics at soft-matter interfaces play an important role in nature and technical applications. Optical single-molecule investigations are noninvasive and capable to reveal heterogeneities at the nanoscale. In this work we develop an autocorrelation function (ACF) approach to retrieve tracer diffusion parameters obtained from fluorescence correlation spectroscopy (FCS) experiments in

This work reports new experimental radiative lifetimes of six 3d2(3F)5s levels in singly ionized titanium, with an energy around 63 000 cm-1 and four 3d2(3F)4p odd parity levels where we confirm previous investigations. Combining the new 5s lifetimes with branching fractions measured previously by Pickering et al., we report 57 experimental log gf values for transitions from the 5s levels. The lif

Arguing against the previous research’s presumption that the subculturalconstitutes a single set of meaning, this article addresses the simplequestion of what constitutes the subcultural? What does it mean when weaddress an object, practice, identity, or meaning structure as subcultural?Through outlining three dominant strands in regards to how subculturaldifference has been defined, the author ar