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Hits from an in silico derived focused library for CRTH2 were transformed into highly selective antagonists with favorable ADME properties. Oral administration of 4-bromo-2-(1-phenyl-1H-pyrazole-4-carbonyl)phenoxyacetic acid (19) inhibited peribronchial eosinophilia and mucus cell hyperplasia in a mouse model of allergic asthma, supporting the therapeutic potential of this novel compound class. In

Using a choice blindness paradigm, it is possible to switch decisions and outcomes in simple choice tasks. Such switches have been found to carry over into later choices, hypothesized to be mediated by beliefs about earlier decisions. Here we investigated participants’ memories for stimuli in a simple choice blindness task involving preferential choices between pairs of faces. We probed participan

Analysis of some media pedagogical aspects of a graduate course within comparative literature at Lund university

Pre-experimental familiarity can have paradoxical effects on episodic memory. Knowledge of the stimulus domain usually enhances memory, but word frequency - a presumed correlate of prior experience - is negatively related to recognition accuracy. The present study examined episodic recognition of names and its relation to two measures of pre-experimental knowledge, name frequency, and fame. Freque

This paper presents a new approach to buffer dimensioning for dynamic dataflow implementations. A novel transformation applied to the execution trace graph of a dataflow program is introduced in order to generate an event driven system. It is shown how model predictive control theory techniques can be applied to such a system to analyse the execution space of a dataflow program and to define and t

We derive an analytic solution to the problem of fixed-time trajectory generation with a quadratic cost function under velocity and acceleration constraints. This problem has a wide range of applications within motion planning. The advantage of the analytic solution compared to numerical optimization of the discretized problem is the unlimited resolution of the solution and the efficiency of the c

The year-book Kyrkohistorisk Årsskrift 2006 contains nine articles on Ecclesiastical History from the twelfth to the twentieth century, as well as several book reviews.

I denna rapport studeras i vilken grad framtida energi- och transportsystem med låga utsläpp av växthusga¬ser är förenliga med övriga svenska miljömål. Utgångspunkt tas i de scenarier som tagits fram i forsk¬ningsprogrammet LETS. Ibland uppkommer synergier som innebär att minskningar av utsläppen av växt¬husgaser samtidigt leder till att det blir lättare att uppnå andra miljömål. I andra fall uppkIn this report potential synergies and conflicts between greenhouse gas mitigation and other environmental objectives (EOs) are studied. A starting point is taken in energy scenarios developed within the research programme LETS (www.lets2050.se). Environmental impacts appear in all steps of the energy chain, from land-use effects (both direct and indirect) of renewable energy extraction to emissio