CD40 plays a central regulatory role in the immune system and antibodies able to modulate CD40 signalling may consequently have a potential in immunotherapy, in particular for treatment of lymphomas and autoimmune disease like multiple sclerosis. As a first step to achieve this goal, we describe the selection and characterization of a novel set of fully human anti-CD40 antibody fragments (scFv) fr

The relative importance of natural selection in the diversification of organisms. can be assessed indirectly using matrix correspondence. The present study determines the environmental and genetic correlates of microgeographical variation in the growth form, leaf form and flower morphology in populations of four Aeonium species from section Leuconium using partial regression methods. The phylogeny

Throughout the 1990s, most rural municipalities in Sweden experienced population declines and were forced to face the constraints of an ageing population. To counter this development a significant share turned to place marketing campaigns and promotion in the hope of attracting new residents. This paper examines the campaign efforts of the Swedish rural municipalities and addresses the question of

Objective. To study degree of blood pressure (BP) control in primary healthcare (PHC) treated hypertensive patients in relation to sex, age, drug treatment, and concomitant diseases. Design. Random sample of patients with hypertension. Setting. Ten PHC centres in the Region of Skane, Sweden. Subjects. All the 30- to 95-year-old patients with hypertension who during the period 12 September to 24 Se

The laterally and mutually constrained inversion (LCI and MCI) techniques allow for the combined inversion of multiple geophysical datasets and provide a sensitivity analysis of all model parameters. The LCI and MCI work with few-layered models, and are restricted to quasi-layered geological environments. LCI is used successfully for inversion of surface wave (SW) seismic data and MCI for combined

The inverse scattering problem for the Schrodinger operator on the half-axis is studied. It is shown that this problem can be solved for the scattering matrices with arbitrary finite phase shift on the real axis if one admits potentials with long-range oscillating tails at infinity. The solution of the problem is constructed with the help of the Gelfand-Levitan-Marchenko procedure. The inverse pro

This study presents an analysis of how the media reported the 2007 elections in Turkey. Past research on election campaign media coverage, particularly newspapers, suggests that the media can play an important role in informing voters. However, much of the research on campaign media coverage has focused on Western democracies with little attention paid to how features of the media system such as p

Background: The 65-kD isoform of glutamic acid decarboxylase (GAD) is a major autoantigen in patients with type 1 diabetes mellitus. This trial assessed the ability of alum-formulated GAD (GAD-alum) to reverse recent-onset type 1 diabetes in patients 10 to 18 years of age. Methods: We randomly assigned 70 patients with type 1 diabetes who had fasting C-peptide levels above 0.1 nmol per liter (0.3

Lumbar arteries are important because they are the main source of blood supply to the lumbar spine structures. However, these vessels and their flow characteristics have received little attention and their role in conditions such as low back pain remains unclear. The present study 1. describes the application of duplex ultrasonography in the assessment of lumbar artery blood flow and 2. evaluates

Lower thrust sheets of the Scandinavian Caledonides derive from the margin of Baltica, which was imbricated during Early Palaeozoic closure of oceans formed during separation of the Baltica, Laurentia and Siberia cratons. At Vistas (Kebnekaise Mts), the Seve Nappe Complex preserves rare lenses of a dolerite-intruded granite formed by anatexis during emplacement of gabbro into metasedimentary rocks

Swifts, Apus apus, spend the night aloft and this offers an opportunity to test the degree of adaptability of bird orientation and flight to different ecological situations. We predicted the swifts' behaviour by assuming that they are adapted to minimize energy expenditure during the nocturnal flight and during a compensatory homing flight if they become displaced by wind. We tested the prediction

During the development of rheumatoid arthritis (RA) autoantibodies to IgG-Fc, citrullinated proteins, collagen type II (CII), glucose 6 phosphoisomerase (G6PI) and some other self-antigens appear. Of these, a pathogenic effect of the anti-CII and anti-G6PI antibodies is well demonstrated using animal models. These new antibody mediated arthritis models have proven to be very useful for studies inv

Several quantitative trait loci regulating murine Lyme arthritis severity have been mapped, including a highly significant linkage found on chromosome 5, termed Bb2Bb3. Within this region, the Ncf1 gene of the phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase has recently been identified as a major regulator of arthritis severity in rodent models of rheumatoid arthritis, an eff

In the weedy plant species Allium vineale (wild garlic), individuals may simultaneously produce sexually and asexually derived offspring, by seed and bulbils, respectively. In this study, genetic and genotypic diversity was determined in samples from 14 European A. vineale populations using nuclear (RAPD) and cytoplasmic (PCR-RFLP of cpDNA) markers to investigate the importance of the different re

Oxidative addition of the silanes R3SiH (R3= Ph3, Et3, EtMe2) to the unsaturated cluster [Os3(µ-H){µ3-Ph2PCH2PPh(C6H4)}(CO)8] leads to the saturated clusters [Os3(µ-H)(SiR3)(CO)9(µ-dppm)](SiR3= SiPh31, SiEt32 and SiEtMe23) and the unsaturated clusters [Os3(µ-H)2(SiR3){µ3-Ph2PCH2PPh(C6H4)}(CO)7](SiR3= SiPh34, SiEt35 and SiEtMe26). Structures are based on spectroscopic evidence and a XRD structure o

The efficiency of trityl bromide (4) and diaryl carbenium ion precursors 5-7 in hydride abstraction from a series of cyclohexenyl molybdenum complexes (2) was investigated. The novel nonracemic hydride abstractors 14a,b were designed and prepared and were shown to effectuate hydride abstraction from prochiral substrate 15 with modest enantioselectivity.

Ag/alumina catalysts with different silver contents for octane-SCR were prepared by impregnation and incipient wetness methods. Activity tests revealed that the decisive factor for high activity is not only a high dispersion of silver, but also the ability of the system to redisperse clustered silver. Determination of dispersion by TEM/HAADF and O-2-chemisorption experiments resulted in values clo

This paper analyses the ability of beta and other factors, like firm size and book-to-market, to explain cross‐sectional variation in average stock returns on the Swedish stock market for the period 1983–96. We use a bivariate GARCH(1,1) process to estimate time-varying betas for asset returns. The estimated variances of these betas, derived from a Taylor series approximation, are used for correct

There is a considerable literature to suggest that adenosine A(1) receptor agonists may have anti-nociceptive effects, and we sought to explore the role of adenosine A(1) receptors in a model of trigeminovascular nociceptive transmission. Cats were anaesthetized (alpha-chloralose 60 mg/kg, intraperitoneally), and prepared for physiological monitoring. The superior sagittal sinus (SSS) was stimulat