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Oxidative Stress and Its Biomarkers in Cardiovascular Diseases

Background: Cardiovascular diseases (CVDs) are the most common cause of death worldwide. CVDs share heterogeneous pathophysiologic mechanisms, one of which includes increased oxidative stress. Main Body: Surplus levels of reactive oxygen species induce damage to cellular macromolecules such as DNA, proteins, and lipids. Increased reactive oxygen species result in decreased nitric oxide availabilit

An immuno-inflammatory profiling of asymptomatic individuals in a malaria endemic area in Uganda

Malaria caused by Plasmodium falciparum leads to the destruction of red blood cells (RBCs). A better understanding of how naturally immune individuals control infections should be valuable for future vaccine studies. Antibodies against RBCs and RBC surface antigens were measured together with different inflammatory markers in healthy adults living in a malaria endemic area of Uganda and compared t

Synergistic effects of carbon coating and Bi-bridge in S-scheme C@CuO/Bi/Bi2MoO6 nanocomposites for enhanced photoreduction of Cr(VI)

The S-scheme mechanism in photocatalysis offers a promising approach to significantly enhance photoreductive activity. Here, using Bi dots as electronic media, and by changing the amount of added C@CuO on the surface of flower-shaped Bi2MoO6, a diverse range of CBM-x heterojunctions, were synthesized using a multi-step approach that incorporated solvothermal preparation and calcination methods. CB

Together but still alone - A qualitative study exploring how family members of persons with incurable oesophageal or gastric cancer manage everyday life

Background: Cancer affects not only the person with the disease but those around them. Being a family member is described as strenuous and, often, associated with stress, anxiety and feelings of loneliness. There is a heightened risk of distress for family of those with fast-progressing, severe oesophageal or gastric cancer. Early palliative care involving family is vital yet often overlooked. In

Dose conversion in retrospective dosimetry : Results and implications from an inter-laboratory comparison featuring a realistic exposure scenario

Dose conversion coefficients attempt to harmonize the material-, location-, and exposure-dependent results from retrospective dosemeters. The issues and uncertainties arising from dose conversion are explored within the framework of an interlaboratory comparison exercise in which mobile phones were positioned around anthropomorphic phantoms and exposed to non-uniform photon fields, with the glass

Exploring vacuum foam drying as an alternative to freeze-drying and spray drying for a human lipase

This article compares and explores vacuum foam-drying as an alternative drying technology to freeze-drying and spray drying for a recombinant human lipase as the model protein. Materials characteristics such as structure, surface composition and the solid-state properties of the dry materials were compared and investigated. Moreover, the technical functionality in terms of reconstitution character

Management of cardiogenic shock : state-of-the-art

The management of cardiogenic shock is an ongoing challenge. Despite all efforts and tremendous use of resources, mortality remains high. Whilst reversing the underlying cause, restoring/maintaining organ perfusion and function are cornerstones of management. The presence of comorbidities and preexisting organ dysfunction increases management complexity, aiming to integrate the needs of vital orga

Aligning spatial ecological theory with the study of clonal organisms : the case of fungal coexistence

Established ecological theory has focused on unitary organisms, and thus its concepts have matured into a form that often hinders rather than facilitates the ecological study of modular organisms. Here, we use the example of filamentous fungi to develop concepts that enable integration of non-unitary (modular) organisms into the established community ecology theory, with particular focus on its sp

The literary making of a Uyghur feminist : Identity and ethics in Banu's Redemption

Banu’s Redemption (Modanhan 2021) is the first literary work written in Chinese on the topic of re-education camps in Xinjiang, China. The semi-autobiographical novel depicts how Banu, a female Uyghur intellectual, seeks self-redemption and new ethnic and gender identities against increasingly stringent social control and rising ethnic tension in the region. This chapter offers a critical reading

Tissue factor (F3) gene variants and thrombotic risk among middle-aged and older adults : A population-based cohort study

Background: Tissue factor (TF), encoded by the F3 gene, is the main initiator of blood coagulation. The molecular epidemiology of the F3 gene and the relation to venous thromboembolism (VTE) remains to be determined. Objectives: The aim was to determine the molecular epidemiology and the importance of F3 variants for incident VTE by analysis of the population-based MDC study (Malmö Diet and Cancer

Does Fusobacterium in Colorectal Cancer Sites Originate From the Oral Cavity? A Pilot Study

Objectives: Fusobacterium can contribute to oral diseases, but also pose as a systemic risk factor. This genus, and especially F. nucleatum, can be found in colorectal cancer (CRC) tissue and is involved in multiple aspects of this type of cancer. Previous studies indicated a possible oral origin of these bacteria; however, stronger evidence is needed to reach a definitive conclusion. This pilot s

Peripheral biomarkers of Parkinson’s disease and its correlation with clinical symptoms : a case-control study

Background: Inflammation significantly impacts Parkinson’s disease (PD), yet the intricate relationship between inflammatory markers and PD remains elusive. Objective: To identify the peripheral biomarkers of PD and its correlation with the motor and non-motor symptoms of PD. Methods: 79 PD patients and 65 controls were included in this study. Clinical information and the serum levels of IL-8, IL-

Reuse of building materials : The perspective of Swedish clients

In the context of the circular economy, there is an urgent need for transformation into circular material flows by avoiding waste, reducing extraction of virgin raw materials, and extending product life cycles. Within the construction and real estate industry, the reuse of building materials stands out as a critical strategy for value retention. The objective of this paper is to localise the foref

A Data-driven Riccati Equation

Certainty equivalence adaptive controllers are analysed using a “data-driven Riccati equation”, corresponding to the model-free Bellman equation used in Q-learning. The equation depends quadratically on data correlation matrices. This makes it possible to derive simple sufficient conditions for stability and robustness to unmodeled dynamics in adaptive systems. The paper is concluded by short rema

Remote Sensing Aircraft Target Detection Algorithm Based on Improved YOLOv5s

To solve the problem of low precision measurement accuracy of aircraft target algorithm in remote sensing images, an improved YOLOv5s algorithm was proposed based on YOLOv5s algorithm for aircraft target identification. The backbone network, neck network, output and loss function parts of YOLOv5s network were improved respectively. Spatial pyramid pooling-fast module was replaced by atrous spatial

Are electricity prices and cross-subsidies a barrier to decarbonising India's steel industry?

The main options for deep decarbonisation of primary steel production are to continue using coal and employ carbon capture and storage (CCS) or to change the production process to direct reduction by utilizing hydrogen produced from renewable energy resources. In India, the world's second-largest steel producer, a shift to renewables is inhibited by the current power market regime, which includes

Resilience: why should we think with care?

Resilience has become a ubiquitous term. Individuals, communities and societies are increasingly called upon to be resilient and build resilience as a way to withstand and bounce back from compound climate-induced shocks, conflicts, health and economic crises. In this provocation we critically interrogate the potential that resilience holds for moving beyond a world marked by crises and widening i

Impact of Oral Infection on Organ Transplantation : A Systematic Review

Objectives: Posttransplant infections may lead to dire consequences in immunocompromised organ recipients. Oral foci of infection are therefore often eliminated prior to solid organ transplantation to reduce posttransplant morbidity. However, despite increasing numbers of organ transplantations the necessity of pretransplant dental treatment and its effect on transplant outcome remains uncertain.