The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 years as very few and mostly just palliative treatments are available. As the five years survival rate remains around 5%, the identification of novel pharmacological targets and development of new therapeutic strategies are urgently needed. Here we demonstrate that inhibition of the G protein-coupled

Remediation of soil contaminated with cadmium (Cd) and lead (Pb) is critical for tobacco production. Silicon (Si) fertilizer can relieve heavy metal stress and promote plant growth, however, it remains unknown whether fertilization with Si can mitigate the effects of Cd and Pb on tobacco growth and alter microbial community composition in polluted soils. Here we assessed the effect of two organic

During the past years, activist movements have increasingly turned to social media to raise awareness and critically discuss current development and future scenarios. As a contribution to the discussion of new social movements and activism in the digital age, this study aims to explore and critically discuss how environmental risks and crisis are visually communicated in activism campaigns on Inst

The prevailing global climate transition is incentivized to occur in a short period of time. Hydrogen is considered a pivotal element towards a renewable energy system. However, the physical and chemical properties of hydrogen give rise to the risk of fire and explosion. This risk must be evaluated as hydrogen becomes increasingly integrated into society. This paper aims to investigate whether the

As more and more urban areas are planning and responding to climate change there is a need to understand the role that local action is having at the national and international level. The Paris Agreement called for a global goal on adaptation but in practice aggregating progress on adaptation is hard to achieve. Effective monitoring, evaluation, reporting, and learning systems are crucial to inform

The central nervous system (CNS) controls skeletal muscles by the recruitment of motor units (MUs). Understanding MU function is critical in the diagnosis of neuromuscular diseases, exercise physiology and sports, and rehabilitation medicine. Recording and analyzing the MUs’ electrical depolarization is the basis for state-of-the-art methods. Ultrafast ultrasound is a method that has the potential

Inflammatory mediators induce emergency myelopoiesis and cycling of adult hematopoietic stem cells (HSCs) through incompletely understood mechanisms. To suppress the unwanted effects of inflammation and preserve its beneficial outcomes, the mechanisms by which inflammation affects hematopoiesis need to be fully elucidated. Rather than focusing on specific inflammatory stimuli, we here investigated

Glypicans (GPC1-6) are associated with tumorigenic processes and their involvement in neoplastic behavior has been discussed in different cancer types. Here, a cancer-wide GPC expression study, using clinical cancer patient data in The Cancer Genome Atlas, reveals net upregulation of GPC1 and GPC2 in primary solid tumors, whereas GPC3, GPC5 and GPC6 display lowered expression pattern compared to n

Acute respiratory distress syndrome (ARDS) is a life-threatening condition with mortality rates between 30-50%. Although in vitro models replicate some aspects of ARDS, small and large animal models remain the primary research tools due to the multifactorial nature of the disease. When using these animal models, histology serves as the gold standard method to confirm lung injury and exclude other

En populärvetenskaplig artikel som beskriver Lunds studentkårers stora och lilla standar och deras historia, samt försöker sätta dem i en historisk kontext.

The aim of this master thesis is to investigate how public libraries through projects work to include the target group youth/young adults. To get an understanding of this I will examine five projects towards youth/young adults at public libraries in Skåne. The theoretical framework I have used is the four-space model. The method being used is an ethnographic content analysis of documents from the

The return of cultural property (also known as repatriation or restitution) is a process that is increasing at Swedish museums in the 21st century. Many objects have been returned to their country of origin and their individual journey have been well researched. However, research focusing on institutional changes at the museums, from which the objects have been returned, has not been given the sam

Skeletal muscles are functionally regulated by populations of so-called motor units (MUs). An MU comprises a bundle of muscle fibers controlled by a neuron from the spinal cord. Current methods to diagnose neuromuscular diseases and monitor rehabilitation, and study sports sciences rely on recording and analyzing the bio-electric activity of the MUs. However, these methods provide information from

Hos patienter med medelsvår/svår långvarig icke-malign smärta är två av fem patienter förskrivna opioida läkemedel vid undersökning 2015–2017 vilket inte ligger i linje med aktuella behandlingsriktlinjer som avråder från långvariga behandlingar med opioida läkemedel då behandlingsnytta är oklar och risker väl belagda.

All assessments are events within a process that has the goal of making decisions about instruction, learning, curriculum, students, institutions, and consequences. Three underlying disciplines (i.e., psychometrics, psychology, and sociology) inform the evaluation of assessments. Error is ubiquitous in the selection of tasks that constitute an assessment, the administration, marking, reporting, an

Much has been written about valuing the student voice in UK higher education. The discussion runs alongside an increasing focus from university leadership on improving students’ experiences, and development of the ways in which the student voice is captured, considered, and acted upon. These techniques are central to understanding and developing student engagement (Brooman et al. 2014; Cook-Sather

This Master’s thesis discusses the subject of documenting processes within the archival science, or more accurately the new injunction 2008:4 and the opinions and attitudes Swedish archivists have in regards to it. The national archives of Sweden (Riksarkivet) put out the injunction in 2008 and all the government-owned authorities has to apply it onto their work. They all have to document their