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Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina.

The rd1 mouse serves as a model for inherited photoreceptor degeneration: retinitis pigmentosa. Microarray techniques were employed to compare the transcriptomes of rd1 and congenic wild-type retinas at postnatal day 11, when degenerative processes have started but most photoreceptors are still present. Of the several genes that were differentially expressed, focus was put on those associated with

Inflammation at Birth is associated with Subnormal Development in Very Preterm Infants.

Preterm birth carries a risk for impaired developmental outcome. We have previously described an association between increased levels of pro-inflammatory cytokines during the first 72 postnatal hours and cerebral damage as detected by ultrasound in a cohort of 74 very preterm infants. Sixty-seven of 71 surviving children with a mean (SD) GA of 27.1 (2.0) weeks were examined at 2 years corrected ag

Does social capital protect mental health among migrants in Sweden?

Poor mental health is common among migrants. This has been explained by migration-related and socio-economic factors. Weak social capital has also been related to poor mental health. Few studies have explored factors that protect mental health of migrants in the post-migration phase. Such knowledge could be useful for health promotion purposes. Therefore, this study aimed to analyse associations b

Signaling pathways governing stem cell fate.

Hematopoietic stem cells (HSCs) are historically the most thoroughly characterized type of adult stem cell, and the hematopoietic system has served as a principal model structure of stem-cell biology for several decades. However, paradoxically, although HSCs can be defined by function and even purified to near-homogeneity, the intricate molecular machinery and the signaling mechanisms regulating f

Dual bronchial carcinoids and Cushing's syndrome with a paradoxical response to dexamethasone and a false positive outcome of inferior petrosal sinus sampling.

Objective Establishing the cause of Cushing's syndrome can be a considerable challenge, in particular in ectopic ACTH syndrome, and often requires a combination of biochemical tests and imaging procedures. Subject A 27-year-old man presented with signs of Cushing's syndrome. P-ACTH levels were 3 times above the ULN and free urinary cortisol in the order of 1900 nmol/24 h. The work-up showed remark

fMRI memory assessment in healthy subjects: a new approach to view lateralization data at an individual level.

We present a comprehensive and clinically applicable fMRI test-including both a verbal and a visuospatial task-for assessment of hemispheric specific memory in the medial temporal lobe (MTL). fMRI data was collected from 15 healthy right-handed volunteers. Whole-brain activation was analyzed as well as activation in two regions of interest: the MTL and the anterior speech area. Laterality indices

Stabilization with arbitrary laser polarizations

The interaction of an atom with a very strong and high-frequency laser is investigated in the context of electron wave-packet stabilization and localization. We employ an exact numerical solution of the Schrodinger equation in two space dimensions, which allows for an arbitrary laser ellipticity. Substantially different degrees of stabilization and electron localization patterns are found for vari

Zeaxanthin radical cation formation in minor light-harvesting complexes of higher plant antenna

Previous work on intact thylakoid membranes showed that transient formation of a zeaxanthin radical cation was correlated with regulation of photosynthetic light-harvesting via energy-dependent quenching. A molecular mechanism for such quenching was proposed to involve charge transfer within a chlorophyll-zeaxanthin heterodimer. Using near infrared (880 - 1100 nm) transient absorption spectroscopy

Efficacy of memantine in PDD and DLB: an extension study including washout and open-label treatment.

OBJECTIVE: This 30-week extension trial was a continuation of the first double-blind randomized controlled trial (RCT) to study memantine in dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). The objective was to evaluate the presence of recurrence of symptoms upon drug withdrawal. Furthermore, the aim was to explore washout dynamics in order to inform clinical practice. METHO

Acute plateletpheresis and aprotinin reduces the need for blood transfusion following Ross operation.

The effect of acute intraoperative plateletpheresis (25% platelet yield) in combination with intraoperative low-dose aprotinin (2 million units) on blood conservation was investigated in 18 young adult patients undergoing elective Ross operation. The results were compared with a group of 19 similar patients without plateletpheresis (control group). The hematological and coagulation parameters at a

On the First Come-First Served Rule in Multi-Echelon Inventory Control

A two-echelon distribution inventory system with a central warehouse and a number of retailers is considered. The retailers face stochastic demand and replenish from the warehouse, which, in turn, replenishes from an outside supplier. The system is reviewed continuously and demands that cannot be met directly are backordered. Standard holding and backorder costs are considered. In the literature o

Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.

AIMS/HYPOTHESIS: Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. Moreover, a set of genes influencing oxidative phosphorylation (OXPHOS) is downregulated in diabetic muscle. Here we studied whether genetic, epigenetic and non-genetic factors influence a component of the respiratory chain, COX7A1, previous

Muscle Determinants of Bone Mass, Geometry and Strength in Prepubertal Girls.

PURPOSE:: The aim of this study was to compare the relative contribution of peak muscle force (isokinetic peak torque) with surrogate estimates of muscle force, including leg lean tissue mass (LTM) and vertical jump height (VJH), on bone mass, geometry and strength in healthy prepubertal girls (n = 103). METHODS:: Total leg and FN BMC and leg LTM were measured by DXA; the hip strength analysis pro

Alterations of telomere length and DNA methylation in hairdressers: A cross-sectional study.

Working as hairdressers has been associated with increased risk for cancer, particularly bladder cancer. To evaluate if current hairdressers have elevated risks of adverse health effects, we measured several biomarkers related to cancer-related DNA alterations. We enrolled 295 hairdressers and 92 non-hairdressers (all female non-smokers) from Stockholm and southern Sweden. Questionnaire data were

Distribution of the maximum in air pollution fields

Air quality standards are set to protect public health. The values of the standards are often based on health effect studies, without any statistical considerations. In order to judge if a standard is met measurements of ambient air quality are taken at monitoring stations, and these measured values are used to decide whether or not the standard has been violated. In this paper we examine the stat

Water Vapor Transport and Moisture Budget over Eastern China: Remote Forcing from the Two Types of El Nino

The water vapor transport and moisture budget over eastern China remotely forced by the cold-tongue (CT) and warm-pool (WP) El Nino show striking differences throughout their lifetime. The water vapor transport response is weak in the developing summer but strong in the remaining phases of CT El Nino, whereas the opposite occurs duringWP El Nino. WP El Nino causes a moisture deficit over the Yangt