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Pressurized fluid extraction of bioactive compounds from Phormidium species

In the search for new functional ingredients with potential use in the food industry, extracts of unknown species of microalgae, such as Phormidium species have been studied. Three solvents of different polarities (i.e., hexane, ethanol, and water) have been used to obtain pressurized liquid extracts with different compositions. Moreover, extractions were performed at four different extraction tem

A systematic study on the interactions between carnosic acid and ethylpyrrolidine methacrylate-methyl methacrylate copolymer in supercritical media

In the present work, a systematic study on the interactions between carnosic acid (potent natural antioxidant from rosemary) and ethylpyrrolidine methacrylate-methyl methacrylate (EPyM/MMA) copolymer (synthesized in our laboratory) has been performed using different spectroscopic and thermogravimetric techniques. By comparing data obtained for the reference sample (carnosic acid + copolymer) with

Subcritical water extraction of nutraceuticals with antioxidant activity from oregano. Chemical and functional characterization

In the present work, oregano leaves (Origanum vulgare L.) are explored as natural source of nutraceuticals with antioxidant activity. To do this, subcritical water extraction (SWE), a new environmentally friendly technique, is employed as extraction procedure and HPLC coupled to DAD is used for the chemical characterization of the extracts. Moreover, the radical scavenging 1,1-diphenyl-2-picrylhyd

A click approach to unprotected glycodendrimers

Click chemistry in combination with ultrafiltration has allowed the quick, efficient, and reliable multivalent conjugation of unprotected alkyne-derived carbohydrates to three generations of azido-terminated gallic acid-triethylene glycol dendrimers under aqueous conditions. The reported procedure allows the atom economical incorporation of up to 27 unprotected fucose, mannose, and lactose residue

Expanded national database collection and data coverage in the FINDbase worldwide database for clinically relevant genomic variation allele frequencies

FINDbase (http://www.findbase.org) is a comprehensive data repository that records the prevalence of clinically relevant genomic variants in various populations worldwide, such as pathogenic variants leadingmostly tomonogenic disorders and pharmacogenomics biomarkers. The database also records the incidence of rare genetic diseases in various populations, all in well-distinct data modules. Here, w

Eleven Nearly Zero New Building Life Cycle Cost and Dynamic Performance Optimization by Computer Modeling in Cold Climate

The study aims to generate Building system performance design optimization for 11 nearly zero energy new building (nZEnB) types in the cold climate conditions for decision making. The coupling evolutionary algorithms with a building dynamic simulation engine has been applied to reach the "true" optimal solutions. Life cycle cost and performance modulation was carried out in the multi-objective com

The Concepts of Trademark Exhaustion and Parallel Imports : A Comparative Analysis between the EU and the USA

The article intends to analyze the closely correlated concepts of trademark exhaustion and parallel imports. The growing importance of these concepts in the current world, especially in the European Union, makes it an interesting research topic, even though the concepts are complicated due to their nature and different actors involved. The authors use comparative approach, concentrating on two wor

Urban Living Labs: Governing Urban Sustainability Transitions

Urban Living Labs (ULL) are advanced as an explicit form of intervention delivering sustainability goals for cities. Established at the boundaries between research, innovation and policy, ULL are intended to design, demonstrate and learn about the effects of urban interventions in real time. While rapidly growing as an empirical phenomenon, our understanding of the nature and purpose of ULL is sti

Narrow sieves for parameterized paths and packings

We present parameterized algorithms for the k-path problem, the p-packing of q-sets problem, and the q-dimensional p-matching problem. Our algorithms solve these problems with high probability in time exponential only in the parameter (k, p, q) and using polynomial space. The constant bases of the exponentials are significantly smaller than in previous works; for example, for the k-path problem th

Let the learners take the lead for their lifelong learning journey

This chapter is centered on the importance of letting learners take the lead in their lifelong educational journey, meeting the challenges that they encounter. Additionally, the chapter focuses on new modes of learning in the digital era. The role transfers and professional development of managers, leaders, and academics are discussed, as well as the need for the development of digital academic sc

Single-shot Raman linewidth measurements using time-resolved rotational CARS

A novel hybrid picosecond-nanosecond rotational CARS system is demonstrated for measurements of Raman linewidths of N2 and O2 at ambient conditions. Averaged data agree very well with previous results. The single-shot linewidth measurements are consistent with the linewidths extracted from averaged data. The potential for simultaneous thermometry and linewidth measurements on a single-shot basis i

Similar 1-year subjective outcome after a distal radius fracture during the 10-year-period 2003–2012 : A longitudinal register-based study involving 3,666 patients

Background and purpose — During the last decades, treatment of distal radius fractures (DRFs) has changed, with surgical intervention being more common and with new techniques. We investigated whether this change has influenced the subjective outcome. Here we report, year by year, the 1-year score after a DRF over a 10-year-period, using a patient-reported outcome measure. Patients and methods — P

Dissociation dynamics of highly excited molecules: Theory and Experiment

This thesis presents studies on dissociation of two model molecules: Butadiene and Cyclopropane. Tunable synchrotron radiation was used to ionize or excite the molecules in the gas phase, and the momentum correlation of the resulting fragment ions were measured using a 3D momenta coincident ion spectroscopy. The experimental results were interpreted with the aid of ab-initio quantum calculation. T

Occupational exposure to particles and mitochondrial DNA : Relevance for blood pressure

Background: Particle exposure is a risk factor for cardiovascular diseases. Mitochondrial DNA (mtDNA) is a primary target for oxidative stress generated by particle exposure. We aimed to elucidate the effects of occupational exposure to particle-containing welding fumes on different biomarkers of mtDNA function, and in turn, explore if they modify the association between particle exposure and card

Stroke alters behavior of human skin-derived neural progenitors after transplantation adjacent to neurogenic area in rat brain

Background: Intracerebral transplantation of human induced pluripotent stem cells (iPSCs) can ameliorate behavioral deficits in animal models of stroke. How the ischemic lesion affects the survival of the transplanted cells, their proliferation, migration, differentiation, and function is only partly understood. Methods: Here we have assessed the influence of the stroke-induced injury on grafts of

Bioengineered nerve conduits and wraps for peripheral nerve repair of the upper limb

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess and compare the effects and complication rates of licensed bioengineered nerve conduits or wraps for surgical repair of traumatic peripheral nerve injuries of the upper limb. To compare effects and complications against the current gold surgical standard (nerve autograft).