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Probing the impact of advanced melting and advanced adsorption phenomena on the accuracy of pore size distributions from cryoporometry and adsorption using NMR relaxometry and diffusometry

The accuracy of pore size distributions (PSD) obtained from gas adsorption and cryoporometry is compromised by the presence of advanced adsorption and advanced melting effects, respectively. In order to improve PSD accuracy, it is necessary to know the extent of such effects. In this work cryoporometry and adsorption have been combined to study the onset of advanced melting effects in a sample par

Differences in genetic diversity and reproductive performance of a moss, a leafy liverwort, and a thalloid liverwort from forests of contrasting ages

Two competing predictions regarding highly dispersible clonal plants, such as bryophytes, expect levels of genetic diversity to either increase or decrease over time following a disturbance that opens habitat for colonization. Following up on previous research that found higher levels of genetic variation in bryophytes from relatively undisturbed forest sites, we examined unisexual, haploid specie

Bryophytes of Surtsey, Iceland: Latest developments and a glimpse of the future

Surtsey island was formed in a volcanic eruption south of Iceland in 1963 – 1967 and has since then been protected and monitored by scientists. It is the youngest island in the Vestmannaeyjar archipelago. The archipelago is of volcanic origin, but the other islands are ca. 5 000 to 40 000 yrs old. The first two moss species were found on Surtsey as early as 1967 and several new bryophyte species w

Social Infrastructure and the Alleviation of Loneliness in Europe

In Europe, individualist societies, in which people more highly value independence, have fewer people who are lonely. Yet these societies also have more people who live alone, a strong determinant of loneliness. Evidence suggests that some unrecognized societal-level resources or characteristics can explain this.We uncover multiple pathways toward a lower degree of loneliness among European societ

Dysregulated Lipid Synthesis by Oncogenic IDH1 Mutation Is a Targetable Synthetic Lethal Vulnerability

UNLABELLED: Isocitrate dehydrogenase 1 and 2 (IDH) are mutated in multiple cancers and drive production of (R)-2-hydroxyglutarate (2HG). We identified a lipid synthesis enzyme [acetyl CoA carboxylase 1 (ACC1)] as a synthetic lethal target in mutant IDH1 (mIDH1), but not mIDH2, cancers. Here, we analyzed the metabolome of primary acute myeloid leukemia (AML) blasts and identified an mIDH1-specific

Reprogramming Cancer into Antigen Presenting Cells as a Novel Immunotherapy

Therapeutic cancer vaccination seeks to elicit activation of tumor-reactive T cells capable of recognizing tumor-associated antigens (TAAs) and eradicating malignant cells. Here, we present a cancer vaccination approach utilizing myeloid lineage reprogramming to directly convert cancer cells into tumor reprogrammed-antigen presenting cells (TR-APCs). Using syngeneic murine leukemia models, we demo

The stem cell-supporting small molecule UM171 triggers Cul3-KBTBD4-mediated degradation of ELM2 domain-harboring proteins

To chemically modulate the ubiquitin-proteasome system for degradation of specific target proteins is currently emerging as an alternative therapeutic modality. Earlier we discovered such properties of the stem cell-supporting small molecule UM171 and identified that members of the CoREST complex (RCOR1 and LSD1) are targeted for degradation. UM171 supports the in vitro propagation of hematopoieti

Moisture-dependent response of soil carbon mineralization to temperature increases in a karst wetland on the Yunnan-Guizhou Plateau

Wetlands are facing gradual drying, leading to large carbon loss due to the transformation from anaerobic to aerobic conditions, but the temperature and drought effects from the temperature and moisture fluctuation on soil organic carbon (SOC) mineralization remain uncertain. An incubation study with three moisture levels (100%, 60%, and 40% WHC, marked as W100, W60, and W40, respectively) and fou

Role of quasiparticle structure in α decay of superheavy nuclei

We use the superfluid tunneling model (STM) to calculate the half-lives of α decays of odd-A and odd-odd superheavy nuclei (SHN) with Z≥100 and A≥250. The experimental data are reproduced to accuracies comparable to other contemporary models of the α decay of the SHN. We then apply the STM to examine the influence of the quasiparticle structure on the properties of the chains of α decays arising f

Preventing falls with the LIVE-LIFE program: Pilot outcomes of a multicomponent OT-led intervention addressing health-related and home-related fall risks in community-living older adults

Introduction: There are multiple contributors to falls in older adults. Both health-related (poor balance, polypharmacy, and poor vision), and home-related (home hazards). However, most fall risk interventions only address one or two. The successful Lifestyle Intervention Functional Exercise (LiFE) program could likely be developed into a multicomponent intervention. Objectives: The objectives wer

Suddenly at risk: Older adults’ changes in everyday life early on during the COVID-19 pandemic

ABSTRACT:Introduction / Rationale: From the onset of the COVID-19 pandemic, social distancing was recommended for adults 70 years and older (70+) in Sweden. From an outside view, they then became deprived of possibilities to engage in meaningful activities. However, as meaning is highly subjective, we need to listen to older adults’ voices to really know.Objectives: To explore how adults 70+ exper

Ekonomiska och sociala konsekvenser av och risker med en koncentration av fiskemöjligheter till ett mindre antal aktörer

Havs- och vattenmyndigheten har föreslagit att svenskt demersalt fiske (fiske efter bottennära arter som räka, kräfta, torsk) ska regleras med överlåtbara fiskerättigheter. En förväntad effekt av detta är en koncentration av fisket till färre men större företag. Illustrativa exempel från isländskt fiske och det svenska pelagiska fisket (sill, skarpsill, makrill) som förvaltas med liknande system v

Can Deep Synthesis of EMG Overcome the Geometric Growth of Training Data Required to Recognize Multiarticulate Motions

By being predicated on supervised machine learning, pattern recognition approaches to myoelectric prosthesis control require electromyography (EMG) training data collected concurrently with every detectable motion. Within this framework, calibration protocols for simultaneous control of multifunctional prosthetic hands rapidly become prohibitively long - the number of unique motions grows geometri

1-130 : Selected works Ghassan Bishouty b. 1941 Safad, Palestine — d. 2004 Amman, Jordan

Which images are made manifest across an artist’s practice and which are the ones that disappear? How do objects—whether seen or unseen—and the knowledge they possess traverse across place and time to avow their resistance? These are amongst the questions asked by artist Nour Bishouty in her artist’s book 1—130, a project that draws upon her ongoing research into the works of her father, Ghassan B

Rosa Barba in "Strata: arte italiana dal 2000. Le parole degli artisti"

Strata compiles 37 conversations with artists whose work has made a significant contribution to the Italian and international art scene since 2000. This book is the personal account of a number of encounters, friendships, and professional relationships that Vincenzo de Bellis and Alessandro Rabottini have nurtured over the past twenty years. The conversations explore pivotal moments in each artist

An active-under-coil RFDAC with analog linear interpolation in 28-nm CMOS

This paper demonstrates a wideband 2.4 GHz $2\times 9$ -bit Cartesian radio-frequency digital-to-analog converter (RFDAC). Active-under-coil integration is introduced in the physical implementation, where all key active circuitry is located underneath the matching-network transformer, achieving a core area of merely 0.35 mm2. An 8× analog linear interpolation at the RF rate is proposed to suppress

Between Circles and Constellations

This publication accompanies the exhibition of the same title co-produced by MACBA Museu d’Art Contemporani de Barcelona and Sharjah Art Foundation of the United Arab Emirates. The book brings together projects that this French-Moroccan artist has produced over the last ten years, among them films, video installations, photographs and documentary material. The publication also includes documentati

Harmonic Oscillators in CMOS—A Tutorial Overview

The harmonic oscillator is a truly irreplaceable as well as ubiquitous analog integrated circuit. Starting from the basics of its CMOS implementation, we will discuss the phase noise of the harmonic oscillator in some detail, where the intrinsic large-signal operation mandates a time-variant analysis. This will be followed by a survey of the most popular design techniques enabling a low phase nois