PURPOSE. To test the effects of rearing light intensity on retinal function and morphology in the retinoschisis knockout (Rs1-KO) mouse model of X-linked retinoschisis, and whether it affects functional outcome of RS1 gene replacement. METHODS. Seventy-six Rs1-KO mice were reared in either cyclic low light (LL, 20 lux) or moderate light (ML, 300 lux) and analyzed at 1 and 4 months. Retinal functio

Background: Being a family caregiver for a person with Parkinson s disease (PD) can negatively impact health and wellbeing, but it appears less clear to what extent caregivers health/social service needs are met. Objective: We explored the extent to which PD family caregivers experience sufficient access to health/social services, as compared to age-matched controls; and the associations between t

Multiple sclerosis (MS) is associated with inflammatory lesions in the brain and spinal cord. The detection of such inflammatory lesions using magnetic resonance imaging (MRI) is important in the consideration of the diagnosis and differential diagnoses of MS, as well as in the monitoring of disease activity and predicting treatment efficacy. Although there is strong evidence supporting the use of

A recurrent large genomic rearrangement (LGR) encompassing exons 23 and 24 of the BRCA1 gene has been identified in breast-ovarian cancer families of Greek origin. Its breakpoints have been determined as c.5406+664_*8273del11052 (RefSeq: NM_007294.3) and a diagnostic polymerase chain reaction (PCR) has been set up for rapid screening. In a series of 2,092 high-risk families completely screened for

Editing Emily Dickinson considers the processes through which Dickinson's work has been edited in the twentieth century and how such editorial processes contribute specifically to the production of Emily Dickinson as author. The posthumous editing of her handwritten manuscripts into the conventions of the book and the electronic archive has been informed by editors' assumptions about the literary

Experiment är en metod som har haft skiftande öden och anseende inom samhällsvetenskapliga discipliner under årens lopp. För tillfället har experimenten fått en renässans inom flera samhällsvetenskapliga discipliner. Inte minst i samband med de ökande möjligheterna att använda s.k. big data finns ett växande intresse att på olika sätt kombinera detta med experimentell design (Bond et al 2012; Baks

Using focus group interviews, this paper studies the way young people in Sweden employed social media to discuss and mobilise during the on-going European refugee crisis, with a special focus on peer pressure, social interaction and connective action.In 2015, an unprecedented influx of refugees, predominantly from Syria, Iraq, and Afghanistan, entered Europe on foot and in dinghies. The refugee cr

Methane is produced usually from organic waste in a straightforward anaerobic digestion process. However, hydrogen production is technically more challenging as more stages are needed to convert all biomass to hydrogen because of thermodynamic constraints. Nevertheless, the benefit of hydrogen is that it can be produced, both biologically and thermochemically, in more than one way from either orga

Butterfly monitoring schemes are recording programs initiated to monitor nationwide butterfly abundance and distribution patterns, often with help from volunteers. The method generates high-resolution data, but may be associated with a degree of habitat sampling bias if volunteers prefer to survey areas perceived to be high-quality butterfly habitats. This can result in habitats becoming underrepr

The phylogenetic relationships among hemosporidian parasites, including the origin of Plasmodium falciparum, the most virulent malaria parasite of humans, have been heavily debated for decades. Studies based on multiple-gene sequences have helped settle many of these controversial phylogenetic issues. However, denser taxon sampling and genome-wide analyses are needed to confidently resolve the evo

: Current practice of sustainable design encompasses a range of green strategies. Modernpassive design concepts have learned to build upon climate responsive methodology that was found in andinspired from vernacular and traditional buildings. With the present energy crises in Egypt there is a currentfocus on the development of climate sensitive design building approaches. It will be the thrust of

Through two books and a series of video documentations of live performances Mette Ingvartsen makes choreography into a territory of physical, artistic and social experimentation. The Artificial Nature Series focusses on how relations between human and non-human agency can be explored and reconfigured through choreography. By investigating and creating a ‘nonhuman theater’ questions regarding mater

The kinetics of oxygen reduction by Desulfovibrio salexigens Mast1 and the role of polyglucose in this activity were examined and compared with those of strains of D. desulfuricans and D. gigas. Oxidation rates were highest at air saturation (up to 40 nmol of O2min−1 mg of protein−1) and declined with decreasing oxygen concentrations. Studies with cell extracts (CE) indicated that NADH oxidase was