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This chapter mainly deals with biochemical aspects on prostate specific antigen (PSA) and its clinical value. To a limited extent, also other tumor markers, which might be of importance in the evaluation of patients with prostate cancer are discussed. In serum, PSA exists in a free form or bound to antichymotrypsin. Interestingly, only 10% of PSA secreted from cancer cells seems to exist in a free
Med hjälp av mina medarbetare vid institutionen för Radiofysik på universitetet och avdelningen för sjukhusfysik vid lasarettet började vi 1981 bygga Skandinaviens första bildgivande NMR scanner. För att sprida kunskap om medicinska tillämpningar av NMR arrangerade Svensk förening för radiofysik på hösten 1981 en föreläsningsserie med både läkare, fysiker och ingenjörer på seminstationen i Hörby.
From the flashy to the humble - Towerless Medieval Churches in DenmarkThe article investigates a special category of medieval churches, the towerless churches. The Danish concept for “kullet”, meaning bald headed are discussed, an inventory of the towerless churches is established for medieval Denmark, the architecture is analyzed in relation to different ideals and studied from social and economi
Little is known about whether exposure to unconventional oil and gas development is associated with higher mortality risks in the elderly and whether related air pollutants are exposure pathways. We studied a cohort of 15,198,496 Medicare beneficiaries (136,215,059 person-years) in all major US unconventional exploration regions from 2001 to 2015. We gathered data from records of more than 2.5 mil
Drug repurposing is the use of a given therapeutic agent for indications other than that for which it was originally designed or intended. The concept is appealing because of potentially lower development costs and shorter timelines than are needed to produce a new drug. To date, drug repurposing for cardiovascular indications has been opportunistic and driven by knowledge of disease mechanisms or
Across the physics disciplines, the 186Pb nucleus is the only known system, where the two first excited states, together with the ground state, form a triplet of zero-spin states assigned with prolate, oblate and spherical shapes. Here we report on a precision measurement where the properties of collective transitions in 186Pb were determined in a simultaneous in-beam γ-ray and electron spectrosco
From the reaction of 2-hydroxy-6-methylpyridine (L) with iron(ii) tetrafluoroborate, a new mononuclear iron(iii) octahedral complex [FeL6](BF4)3 has been isolated. The color of the complex reversibly changed from red at room temperature to yellow-orange at the liquid nitrogen temperature. Magnetization measurements indicate that iron(iii) in [FeL6](BF4)3 is in a high-spin state S = 5/2, from room
Atomic layer deposition (ALD) is one of the backbones for today’s electronic device fabrication. A critical property of ALD is the layer-by-layer growth, which gives rise to the atomic-scale accuracy. However, the growth rate - or growth per cycle - can differ significantly depending on the type of system, molecules used, and several other experimental parameters. Typically, ALD growth rates are c
Tumor cells pose a challenge to the adaptive immune system, and its key cell types, T and B cells, have frequently been associated with an improved prognosis. The success of immune checkpoint blockade has confirmed the relevance of T cells. However, the role of B cells is increasingly recognized, and highlighted in this review. Recent data suggest that tumors contain a diverse set of B cells refle
Introduction: Understanding factors that associate with neonatal death may lead to strategies or interventions that can aid clinicians and inform families. Objective: The aim of the study was to develop an early prediction model of neonatal death in extremely low gestational age (ELGA, <28 weeks) neonates. Methods: A predictive cohort study of ELGA neonates was derived from the Swedish Neonatal Qu
Hybrid computational schemes combining the advantages of a method of moments formulation of a field integral equation and T-matrix method are developed in this article. The hybrid methods are particularly efficient when describing the interaction of electrically small complex objects and electrically large objects of canonical shapes such as spherical multilayered bodies where the T-matrix method
Background: Prediction tools that combine polygenic risk scores with clinical factors provide a new opportunity for improved prediction and prevention of atherosclerotic cardiovascular disease, but the clinical utility of polygenic risk score has remained unclear. Methods: We collected a prospective cohort of 7342 individuals (64% women, mean age 56 years) and estimated their 10-year risk for athe
Objective: Today, stress monitoring on wearable devices is challenged by the tension between high-detection accuracy and battery lifetime driven by multimodal data acquisition and processing. Limited research has addressed the classification cost on multimodal wearable sensors, particularly when the features are cost-dependent. Thus, we design a Cost-Aware Feature Selection (CAFS) methodology that
Climate warming could destabilise the Earth's largest terrestrial store of reactive carbon (C), by accelerating the decomposition of soil organic matter. A third of that C store resides in the tropics. The potential for tropical soils to sequester C, or to act as an additional source of CO2, will depend on the balance of C inputs and outputs, mediated by the response of soil microbial communities
Aims: To study incident narcolepsy in first- and second-generation immigrant groups using Swedish-born individuals and native Swedes as referents. Methods: The study population included all individuals registered and alive in Sweden at baseline. Narcolepsy was defined as having at least one registered diagnosis of narcolepsy in the Swedish National Patient Register. The incidence of narcolepsy in
Denna andra delen av Hjärnavbildning vid Schizofreni beskriver användningen av radioaktiva ämnen som startade i Lund med professor David Ingvars pionjär studier av att avbilda cerebralt blodflöde med Xenon-133 hos patienter med Schizofreni. De nukelar medicinska metoderna utvecklades till Single Photon Emission Computed Tomography, SPECT, använder gammastrålning som emitteras direkt från internt
Introduction: Minimally invasive methods to reduce menorrhagia were introduced in the 1980s and 1990s. Transcervical endometrial resection (TCRE) and endometrial ablation (EA) are two of the most frequently used methods. As none of them can guarantee a complete removal of the endometrium, there are concerns that the remaining endometrium may develop to endometrial cancer (EC) later in life. The pr
Background and purpose: High levels of 25-hydroxyvitamin D3 (25[OH]D3) are associated with a lower risk for multiple sclerosis (MS). The bioavailability of 25(OH)D3 is regulated by its main plasma carrier, vitamin D-binding protein (DBP). Free 25(OH)D3 can be estimated by also measuring DBP concentration. In addition, DBP has immunomodulatory functions that may independently affect MS pathogenesis
