Acute myeloid leukemia (AML) is a complex hematological malignancy marked by proliferation of immature myeloid cells with a dismal 5-year survival. A major challenge is the persistence of leukemia stem cells (LSCs) after standard treatment, leading to relapse. This thesis employs in vivo CRISPR/Cas9 screening to investigate critical AML and LSC molecular mechanisms, interrogating the dependancies

A palliative cancer diagnosis in a parent has a major impact on many aspects of their children’s lives. Studies show that professionals do not seem to offer relatives, in general, much attention in the palliative fieldAim: To explore how doctors and social workers handle children of cancer patients in order to understand the possibilities and difficulties in supporting children in specialized pall

Background: Measurements of local tissue water and circumferences are methods to evaluate lymphedema. Knowledge about reference values and reproducibility needs, however, to be determined for the head and neck (HN) area of healthy persons before it can be used in persons with HN lymphedema. The objective of this study was to evaluate the test-retest reliability including measurement errors of loca

Interdisciplinary in perspective, this book explores contemporary struggles around ‘identity politics’ in Europe, offering a unique glimpse into contemporary tensions and paradoxes surrounding identities, belonging, exclusions and their deep-seated gendered, colonial and racist legacies. With a particular focus on the Nordic region, it provides insights into the ways in which people who find thems

Forests provide a wide range of ecosystem services, and ecosystem models can be applied to assess the contribution of different forest management strategies to climate mitigation and adaptation. Complex model output and trade-offs between environmental, economic, and social sustainability dimensions are difficult to convey. To facilitate stakeholder communication, we developed composite indicators

Fibre-optic based sensing technologies are becoming popular in the field of geophysics since enable long range and high spatial resolution acoustic measurements. In this work, we present preliminary results obtained using quasi-distributed Fibre-Bragg grating sensing and Distributed Acoustic Sensing (DAS) to monitor seismic activities in an operational underground mine. 12 FBGs and 800 metres of f

Background A parent’s death is a dramatic event, and it can affect children in many ways, both acutely and long-term. Aim To explore how children who had lost a parent were included, acted, and interacted in a support program focusing on relational and contextual aspect.An ethnographic field study consisting of 82 hours of observations, 25 semi-structured interviews, and one focus group interview.

The thermal sensitivity of early life stages can play a fundamental role in constraining species distributions. For egg-laying ectotherms, cool temperatures often extend development time and exacerbate developmental energy cost. Despite these costs, egg laying is still observed at high latitudes and altitudes. How embryos overcome the developmental constraints posed by cool climates is crucial kno

Generation Z has increasingly become one of the fastest-growing travel segments and a crucial market to target. The growth and behaviour of this economically significant market will have enormous implications for the future development of the tourism industry and destinations and its long-term sustainability. This introductory chapter provides a critical examination of Gen Z consumer and travel be

In 2015, the United Nations (UN) General Assembly agreed on 17 Sustainable Development Goals (SDGs) with 169 targets as part of the 2030 Agenda for Sustainable Development. Although the SDGs, which are to be achieved by 2030, are not the first attempt to guide policy actors through global goals, they go far beyond earlier agreements in their detail, comprehensiveness, and ambition. Yet the 2022 SD

Today, the US pursues the global capture of data (understood as a significant engine of growth) by way of bi- and plurilateral trade agreements. However, the project of securing the global free flow of data has been pursued ever since the dawn of digital telecommunication in the 1960s and the US has made significant legal efforts to institutionalise it. These efforts have two phases: In the first

Wild bees foraging in contemporary agricultural landscapes are, because of agricultural intensification, faced with the challenges of reduced flower-rich habitats, as well as a changed spatio-temporal distribution of flower resources. As a result of this and other stressors such as pesticide exposure, widespread declines of bees have been reported. However, all bees are not equally affected. To be

Neuronal loss and axonal demyelination underlie long-term functional impairments in patients affected by brain disorders such as ischemic stroke. Stem cell-based approaches reconstructing and remyelinating brain neural circuitry, leading to recovery, are highly warranted. Here, we demonstrate the in vitro and in vivo production of myelinating oligodendrocytes from a human induced pluripotent stem