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Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer lacking effective drugs and therefore new treatment targets are needed. In this study, we define the role of homeobox protein B6 (HOXB6) and HOXB8 in controlling pancreatic cancer tumorigenesis and immune response. Transcriptomic analysis comparing human embryonic and PDAC tissue identified a large overlap of expression profiles suggesting

Covid-19-pandemin aktualiserade frågor om smittskyddsåtgärder inom äldreomsorgen, särskilt i relation till isolering av äldre. Denna artikel undersöker de rättsliga hinder som finns för att införa isolering – förstådd som ett krav på minimala kontakter med omgivningen – som åtgärd för att begränsa smittspridning på äldreboenden. Artikeln söker i synnerhet besvara frågan om vissa isoleringsåtgärder

BACKGROUND: Food choice decisions are complex processes influenced by various factors that affect the family's diet and, thus, their health and nutrition. In low- and middle-income countries like Ethiopia, these factors are shaped by the ongoing nutrition transition, urbanization, and socio-economic challenges. Despite growing concerns about the double burden of malnutrition, the factors influenci

BackgroundDiagnostic imaging is a dynamic medical field. In nuclear medicine, advancements introduce new procedures utilising innovative radiopharmaceuticals. These developments may influence supply requirements and exposure levels for the patient population. Surveying the frequency of procedures, types of pharmaceuticals, and administered activities provides valuable insights into utilisation tre

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AIM: Factors associated with unexpected absence or presence of coronary atherosclerosis in individuals at high/low estimated cardiovascular (CV) risk are largely unexplored. We assessed two extreme phenotypes: 1) no coronary atherosclerosis despite very high CV risk; and 2) severe-extensive coronary atherosclerosis despite low CV risk.METHODS: A multicenter, cross-sectional nationwide, population-

BackgroundLow- and middle-income countries (LMICs), including Bangladesh, are experiencing a nutritional transition characterized by rising unhealthy food consumption (UFC), which increases the risk of nutrient deficiencies and chronic diseases in children. Despite this concern, research on UFC among Bangladeshi children aged 6–23 months is limited. Therefore, this study aims to estimate the preva

The goal of this article is to demonstrate the importance of pilot studies in empirical eye-tracking research. First, we show what can go wrong when proper pilot experiments are omitted for all phases of an eye-tracking study, from testing an experiment, conducting the data collection, to building, revising, and interpreting the data analysis. Second, we describe a series of eye-tracking studies a

It is often said that we need more 'radical imagination' to challenge the status quo and envision societies otherwise. But what does that really mean? How might it be nurtured? And what role can approaches at the intersection of art and science play? The What If Garden (TWIG) invites you on a journey into radical imagination. Take a walk. Be inspired. Wander, and let your imagination unfold in mov

OBJECTIVE: The primary aim of this study was to confirm the internal consistency and factor structure of the Swedish version of the Swanson-Nolan-Pelham scale fourth edition (SNAP-IV) for parents and to examine its clinical utility for identifying children diagnosed with attention deficit/hyperactivity disorder (ADHD).MATERIALS AND METHODS: Parents of 11-year-old children from a birth cohort in th

This paper provides a practical guide on how to effectively use the MARRYS helmet for recording and analyzing jaw movements in speech research. Rather than introducing the device itself, which has been described in detail in Gudmundsson et al. (2024), this guide focuses on the setup, data collection, and analysis workflows essential for successful experimental work. Applications include language l

In this study we investigated the tongue and jaw movements during heavy metal growling in comparison to modal voice to enlighten us about the relationship between the laryngeal and oral articulator. Similarly to harsh voice, growling employs supraglottic structures like the ventricular and aryepiglottic folds. Previous research suggests that the tongue dorsum assists in laryngeal constriction by r