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Glioblastoma has remained the deadliest primary brain tumor while its current therapy offers only modest survival prolongation. Immunotherapy has failed to record notable benefits in routine glioblastoma treatment. Conventionally, immunotherapy relies on T cells as tumor-killing agents; however, T cells are outnumbered by macrophages in glioblastoma microenvironment. In this study, we explore the

Recently, it was shown that sensory relearning of the upper limb (SENSUPP) is a promising intervention to improve sensorimotor function after stroke. There is limited knowledge, however, of how participants perceive the training. Here, we explored how persons with sensory impairments in the upper limb experienced the SENSUPP protocol (combined sensory-and motor training and home exercises for 5 we

Assessing the causal effects of individual dietary macronutrients and cardiometabolic disease is challenging owing to the complexity to distinguish direct effects from those mediated or confounded by other factors. To estimate these effects, intake of protein, carbohydrate, sugar, fat, and its subtypes were obtained using food frequency data derived from a Swedish population-based cohort (n~60,000

Plasma assisted combustion has been proposed as an efficient technique to enhance combustion, especially under the extreme conditions. For shedding light on the interactions between plasma and turbulent flame at extended conditions, a burner design with integrated electrodes was used to couple a non-thermal gliding arc (GA) discharge to a turbulent flame. The morphology and dynamic behaviors of th

In most control schemes it is advantageous to introduce integrators to eliminate off-set due to load disturbances. It is, however, also important to introduce nonlinearities, for instance due to limitations in actuators. The interaction between the integrator and the nonlinearities will cause problems with reset windup. Ways to handle anti-reset windup for different controller configurations are d

Pole-placement design for SISO systems are discussed in input-output formulation. It is shown how the different design parameters influence the performance of the closed loop system. For instance, the influence of sampling period, anti-aliasing filter, and desired closed loop performance are treated in detail. Rules of thumb for the choice of the different parameters are given.

In this paper we describe how to determine the time delays caused by synchronous and asynchronous control loops. These time delays can vary in a quite irregular way and can cause problems for the control loops closed over a communication network of, for instance, field-buses. Different setups allowing an arbitrary number of communication layers are analyzed. The theoretical derivations are illustr

The purpose of this paper is to develop a model and control algorithm for the slab temperature control problem, which is the control of a number of steel blocks (slabs) passing through a furnace burner zone. The slab temperature is controlled by varying the zone temperatrure. First a model for a single slab passing through the furnace is developed and the parameters are estimated. Data from the re

This paper discusses some problems that can arise in distributed real-time control systems, for instance, sampling- interval jitter, timeout, and asynchronous loops.

Importance: Coverage of essential child health and nutrition interventions in low- and middle-income countries remains suboptimal. Adverse exposures, such as undernutrition and infections, are particularly harmful during the 1000 days from conception until 2 years of age.Objective: To investigate whether deaths in children younger than 5 years-which also reflect adverse exposures faced by children

BACKGROUND: Nearly a quarter of patients with locally advanced (T4 stage) or perforated colon cancer are at risk of developing peritoneal metastases, often without curative treatment options. We aimed to determine the efficacy of adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with locally advanced colon cancer.METHODS: This multicentre, open-label trial was done in nine hos

IntroductionSmall bowel obstruction, infertility, and chronic abdominal pain are generally mentioned as the main clinical consequences of adhesion formation after abdominal surgery1,2. Difficulties experienced during reoperation are less pronounced consequences, but seem to have a huge impact. A large retrospective cohort study3 revealed that adhesiolysis was significantly associated with risk of

This Special Issue provides diverse multidisciplinary entry points that convey the multi-layered complexity of the interactions between radical right populism, gender issues, and religious questions. It fills a gap in the scholarship dealing with the political and social manifestations of radical right populism. From a theoretical point of view, the connections between radical right populism and g

BACKGROUND: Recent advances in disease-modifying treatments highlight the need for accurately identifying individuals in early Alzheimer's disease (AD) stages and for monitoring of treatment effects. Plasma measurements of phosphorylated tau (p-tau) are a promising biomarker for AD, but different assays show varying diagnostic and prognostic accuracies. The objective of this study was to determine

This thesis considers the problem of improving the performance of observed time difference of arrival (OTDOA) based positioning for Narrowband Internet of Things (NB-IoT). A new iterative low-complexity algorithm based on expectation maximization successive interference cancellation (EM-SIC) is presented. The algorithm tackles the near-far problem by using an iterative SIC, where for each receivedThis thesis considers the problem of improving the performance of observed time difference of arrival (OTDOA) based positioning for Narrowband Internet of Things (NB-IoT). A new iterative low-complexity algorithm based on expectation maximization successive interference cancellation (EM-SIC) is presented. The algorithm tackles the near-far problem by using an iterative SIC, where for each received

Freshwater ecosystems are under multiple threats in modern times such as water extraction for human consumption, industries and agricultural activities, water contamination and habitat destruction for example. At the same time the biodiversity of these ecosystems are often poorly studied, especially in arid countries such as Iran. In this work, we study one of the ecologically important members of

We analyze the development of biodiversity offsetting governance through a research-weaving approach. Here, we combine information from a systematized review of the literature and a qualitative analysis of the institutional developments in different world regions. Through this triangulation, we synthesize and map the different developmental streams of biodiversity offsetting governance around the

The purpose of this paper is to describe the design of a multivariable control law for a hot plate mill. The design is performed on models adapted to the plate mill at The Danish Steel Work Ltd. The model for the rolling mill is divided into nonlinear models for the hydraulic systems performing the thickness control and a multivariable linear model for the rolling stand. The parameters of the mode

Itch is a common symptom, but there is limited evidence on the prevalence of itch in children. The aim of this study was to assess the prevalence of itch in schoolchildren. A questionnaire was developed by experts in the field and based on a literature search. The questionnaire was applied in a pilot study of 25 consecutively selected paediatric patients and their parents. It confirmed the high co