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Tools for digital twins in continuous downstream processing

Biopharmaceuticals are of ever-growing importance for human health. The development and production of biopharmaceuticals has the potential for efficiency improvements by switching from batch-wise to continuous production. This change demands more advanced process control in the form of automation and digital tools such as digital twins, which in turn need adequate mathematical models and accessibl

Associations between chronic widespread pain, pressure pain thresholds, leptin, and metabolic factors in individuals with knee pain

Objective: The aim was to study associations between chronic widespread pain, widespread pain sensitivity, leptin, and metabolic factors in individuals with knee pain. A secondary aim was to study these associations in a subgroup of individuals with normal BMI. Method: This cross-sectional study included 265 individuals. The participants were categorised into three different pain groups: Chronic w

Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae

Protein N-terminal (Nt) acetylation is one of the most abundant modifications in eukaryotes, covering ~50-80 % of the proteome, depending on species. Cells with defective Nt-acetylation display a wide array of phenotypes such as impaired growth, mating defects and increased stress sensitivity. However, the pleiotropic nature of these effects has hampered our understanding of the functional impact

The With Or Without Olecranon K-wire (WOW OK) Trial of tension band wire fixation versus cerclage fixation without K-wires in displaced stable olecranon fractures : study protocol for a randomized controlled trial

Background: Displaced olecranon fractures with a stable elbow joint are classified as Mayo type 2a or 2b and are commonly operated with tension band wiring, i.e. two K-wires and a cerclage. Retrospective studies have reported fewer reoperations and complications with cerclage fixation alone when compared to tension band wiring, though with similar long-term results. We decided to compare tension b

Structural and functional analysis of aquaporin-2 mutants involved in nephrogenic diabetes insipidus

Aquaporins are water channels found in the cell membrane, where they allow the passage of water molecules in and out of the cells. In the kidney collecting duct, arginine vasopressin-dependent trafficking of aquaporin-2 (AQP2) fine-tunes reabsorption of water from pre-urine, allowing precise regulation of the final urine volume. Point mutations in the gene for AQP2 may disturb this process and lea

What a waste – A norm-critical design study on how waste is understood and managed

This article seeks to contribute new insights into inclusive recycling environments through universal design. The aim is to develop knowledge on how waste is understood and managed by exploring the practice and design of a recycling environment. Applying a norm-critical view, this is explored in a study with participants from a municipal housing company and waste management company in northern Swe

Health literacy in individuals with knee pain—a mixed methods study

Background: Low health literacy is associated with worse pain and poorer self-management. This study (1) examined the level of health literacy and associations with lifestyle habits, health status, chronic pain, and radiographic knee osteoarthritis; and (2) explored experiences illuminating health literacy among individuals with knee pain. Methods: A convergent parallel mixed-methods design was us

Women’s experience of the health information process involving a digital information tool before commencing radiation therapy for breast cancer : a deductive interview study

Background: Individuals undergoing radiation therapy for breast cancer frequently request information before, throughout and after the treatment as a means to reduce distress. Nevertheless, the provision of information to meet individuals needs from their level of health literacy is often overlooked. Thus, individuals information needs are often unmet, leading to reports of discontent. Internet an

Large eddy simulation of spray and combustion characteristics of biodiesel and biodiesel/butanol blend fuels in internal combustion engines

Biofuel is a crucial renewable and environmentally friendly energy source for addressing greenhouse gas emissions and other energy-related issues. Biodiesel and butanol, among alternative biofuels, possess complementary physical and chemical properties, offering multiple possibilities for their use in existing internal combustion engines. However, biodiesel's distinctly different physical and comb

Expanding the genetic toolbox of Rhodotorula toruloides by identification and validation of six novel promoters induced or repressed under nitrogen starvation

Background: The non-conventional yeast Rhodotorula toruloides is an emerging host organism in biotechnology by merit of its natural capacity to accumulate high levels of carotenoids and intracellular storage lipids from a variety of carbon sources. While the number of genetic engineering strategies that employ R. toruloides is increasing, the lack of genetic tools available for modification of thi

Determinants of health-related quality of life in people with Human Immunodeficiency Virus, failing first-line treatment in Africa

Background: Antiretroviral treatment improves health related quality of life (HRQoL) of people with human immunodeficiency virus (PWH). However, one third initiating first-line treatment experience virological failure and the determinants of HRQoL in this key population are unknown. Our study aims to identify determinants of among PWH failing antiretroviral treatment in sub-Saharan Africa. Methods

Joint optimization of land carbon uptake and albedo can help achieve moderate instantaneous and long-term cooling effects

Both carbon dioxide uptake and albedo of the land surface affect global climate. However, climate change mitigation by increasing carbon uptake can cause a warming trade-off by decreasing albedo, with most research focusing on afforestation and its interaction with snow. Here, we present carbon uptake and albedo observations from 176 globally distributed flux stations. We demonstrate a gradual dec

Making sense of chemical equilibrium : productive teacher-student dialogues as a balancing act between sensemaking and managing tension

Navigating the observational, symbolic, and theoretical knowledge domains of chemistry is crucial for chemistry sensemaking. However, this has been shown to be particularly challenging for students of chemistry. In order to reach government standards for sensemaking in the chemistry subject, it is important to investigate how chemistry teachers can sustain sensemaking practices in their classrooms

Extending StringSpinner to handle vector-meson spin

Quark spin effects in hadronization were recently included in the PYTHIA 8 Monte Carlo event generator for the simulation of the deep inelastic scattering (DIS) process off a polarized proton or neutron target. The spin effects were activated via the external StringSpinner package, which is based on the string+P03 model of polarized hadronization, and were restricted to the production of pseudosca

The Dual Role of Insurance in Input Use: Mitigating Risk Versus Curtailing Incentives

Insurance can encourage the use of risk-increasing inputs, but it can also decrease people's incentives to exert effort when the latter is difficult to monitor. This effort reduction can be associated with a decrease in the use of effort-complementary inputs. I study a model of risk-sharing that allows for both effects of insurance on input use and use the latest ICRISAT panel to structurally esti

Concomitant interfacial spin fractal transformation and exchange bias in a magnetic shape memory alloy

Small-angle neutron scattering is used to study the exchange bias effect in Mn50Ni40Sn10. The martensitic transformation is found to be responsible for the nanometer-scale spin clusters (SCs) inside the low-temperature ferromagnetic (FM) martensite phase. The magnetic field dependences of the SCs and FM domains exhibit an asymmetry that characterizes the exchange bias. We find that the surface geo

Neutron adiabaticity and its impact on data analysis, illustrated for polarized GISANS

The significance of neutron spin adiabaticity in the data analysis of polarized Grazing Incidence Small Angle Neutron Scattering (GISANS) is discussed, with the aim of minimizing the number of simulation parameters of complex magnetic models within the neutron scattering cross-section. We illustrate how an estimate of the neutron polarization direction and adiabaticity can be obtained by magnetic

Polarisation Development at the European Spallation Source

To meet the ever-increasing user demand, eleven of the fifteen European Spallation Source (ESS) instruments under construction aim to offer polarised neutrons for user experiments. They include an imaging instrument, a SANS instruments, two reflectometers, three diffractometers, and four spectrometers. In conjunction with in-kind contributions and instrumentation grants, the ESS Polarisation Proje