Wound healing that precedes scar formation may be unbalanced under pathological conditions leading to structural changes of the tissue. At the moment, the mechanisms behind this unbalance are unclear. When these changes occur in internal organs such as the lung, they may result in organ dysfunction with fatal consequences for the patient. This phenomenon is defined as airway remodeling, and occurs

Popular Abstract in Swedish Ärftlig blindhet orsakas oftast av sjukdomar där näthinnans fotoreceptorer, som ombesörjer omvandlingen av ljus till elektriska impulser, degenererar. Det anses att denna celldödsprocess styrs av ett antal olika mekanismer och projektets mål är att försöka identifiera och karaktärisera dessa mekanismer. Retinitis Pigmentosa (RP) är en ärftlig sjukdom där en genetisk defRetinitis pigmentosa (RP) is an inherited disorder and the leading cause of visual impairment in the working age population. It is caused by a number of different genetic mutations, all of which cause the rod photoreceptors to degenerate. As the rods become few in numbers, the cones will also begin to die, resulting in total blindness. Since the genetic defects leading to RP are numerous, it would

A platform for rapid on-line protein digestion of protein mixtures for direct infusion to a mass spectrometer is presented. A mixture of protein A, staphylococcal enterotoxin B and cytochrome c was used as a model mixture injected on a gel filtration column and a trypsin reactor which were connected in series to a micro liquid chromatography (mu LC) system. The peptides in the column eluate were a

The present results demonstrate that chronic nicotine treatment can in part protect against mechanically-induced and neurotoxin-induced degeneration of nigrostriatal DA neurons. These results indicate that in sufficient doses chronic treatment with nicotine may be considered in the pharmacological treatment of Parkinson's disease. It remains to be demonstrated whether these protective actions can

The plant enzyme sucrose synthase (SuSy; EC 2.4.1.13) catalyzes the reversible conversion of sucrose and UDP into UDP-glucose (UDP-Glc) and fructose. The enzyme exists in different isoforms and is both located in the cytosol, membrane-bound and associated to the actin cytoskeleton. We here investigate sucrose synthase from tobacco (Nicotiana tabacum L.) BY-2 heterotrophic cell suspensions. Two dif

The effects of two different prevention programmes on: (1) reported neck, shoulder and back pain, (2) perceived physical exertion at work and perceived work-related psychosocial factors, were evaluated by questionnaires after 12 and 18 months. Female nursing aides and assistant nurses (n = 282) working in the home-care services, were randomly assigned to one of three groups for: (1) individually d

Popular Abstract in Swedish Syftet med studien är att bestämma de faktorer som påverkar eleverna då de löser matematiska problem i årskurserna 4-9 i grundskolan. Metoden, som använts, består i en analys av lösningarna till 25 problem, som getts i var och en av årskurserna. Några av problemen har varit desamma i alla årskurserna och ungefär 100 elever har deltagit i varje årskurs. Genom att undersöThe purpose of this study is to identify the factors influencing pupils when they individually solve problems in mathematics in grades 4-9 in the compulsory school (ages: 10-16 years). The method that has been used is an analyses of the solutions of 25 problems given to each grade. Some of the problems were the same in all grades and about 100 pupils participated in each grade. Through an examinat

We studied the prevalence of musculoskeletal pain and its impact on performance in orchestra musicians and in a reference group of actors, who share the mental stress in a performance situation, but without having the physical work load from an instrument. Swedish musicians (n = 103) from symphony and chamber orchestras and actors (n = 106) participated in a cross-sectional questionnaire study. Mu

The steadily increasing prevalence of diabetes constitutes a major health problem. By the year 2025, the prevalence of diabetes is estimated to be as high as 5.4 %. This is to be compared with reports from Swedish coronary care units, which suggest that as many as 66 % of the patients admitted in fact have previously undiagnosed diabetes or pre-diabetes (impaired glucose tolerance) 1. Cardiovascul

This chapter investigates nominals in the early monolingual acquisition of Swedish. The major morphological properties of nominals in the adult grammar are described with regard to gender, number, definiteness, and nominal-internal agreement between determiner, adjective and noun. I summarise the empirical findings in the existing literature on the acquisition of nominals for Swedish children betw

Stability of systems in the presence of bounded uncertain time-varying delays in the feedback loop is studied. The delay parameter is assumed to be an unknown time-varying function for which the upper bounds on the magnitude and the variation are given. The stability problem is treated in the integral quadratic constraint (IQC) framework. Criteria for verifying robust stability are formulated as f

Structural and electronic properties of a small anatase TiO2 nanocrystal sensitized by the ruthenium dye N3 (Ru(4,4‘-dicarboxy-2,2‘-bipyridine)2(NCS)2) have been investigated using density functional theory (DFT) with support from Hartree−Fock (HF) and time dependent DFT (TD-DFT) calculations. Significant structural adjustments of both the dye and the nanocrystal are predicted to be induced by the

Background and Objectives: Intense pulsed light (IPL) systems are increasingly used for treatment of photo damaged skin. In the present study, we investigated the clinical efficacy and safety of two different wavelength bands generated by the same IPL device. Study Design/Materials and Methods: An IPL device was equipped with either a 555-950 nm filter (VL), or a 530-750 nm filter (PR). Results: F

PURPOSE: To assess the diagnostic efficacy, safety and tolerability of mangafodipir trisodium (MnDPDP, Teslascan) in MR imaging of the liver. MATERIAL AND METHODS: Eighty-two patients from 4 centres underwent MR imaging with pre-contrast sequences including T1-weighted SE and GRE, and T2-weighted turbo SE sequences. MnDPDP at a dose of 5 mumol/kg b.w. was administered by slow i.v. infusion, and 20

BACKGROUND: To compare women with and without a history of recurrent symptoms suggestive of a urinary tract infection but a current negative urine culture regarding symptoms and signs of a genital infection, carriership of sexually transmitted agents and vaginal flora changes, sexual behavior and genital hygiene practice. SETTINGS: Contraceptive attendees at family planning and youth clinics. MATE